AEE788

目录号: A10043

EGFR 抑制剂

AEE788

AEE788 Chemical Structure

CAS NO. 497839-62-0

AEE788是一种口服生物可用的多受体酪氨酸激酶抑制剂,可抑制EGFR,HER2和VEGF2酪氨酸激酶的磷酸化。

库存: 现货

规格 价格 数量
5 mg
¥ 630.00
10 mg
¥ 1,120.00
25 mg
¥ 2,240.00
50 mg
¥ 3,850.00
10mM * 1mL in DMSO
¥ 1,155.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

AEE788是一种口服生物可用的多受体酪氨酸激酶抑制剂,可抑制EGFR,HER2和VEGF2酪氨酸激酶的磷酸化。
Targets
Target Value
EGFRIC50: 2nM
HER2/ErbB2IC50: 6nM
c-AblIC50: 52nM
FLT1IC50: 59nM
c-FmsIC50: 60nM
c-SrcIC50: 61nM
KDRIC50: 77nM
HER4/ErbB4IC50: 160nM
PDGFRβIC50: 320nM
FLT4IC50: 330nM
FLT3IC50: 730nM
RETIC50: 740nM
c-KitIC50: 790nM
TekIC50: 2.1μM
C-Raf-1IC50: 2.8μM
c-MetIC50: 2.9μM
CDK1/CyclinBIC50: 8.0μM
IGF-1RIC50: >10μM
Insulin ReceptorIC50: >10μM
PKCαIC50: >10μM
PKAIC50: >10μM
In vitro (25°C) DMSO 81 mg/mL (183.84 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.7 mL 113.48 mL 226.96 mL
0.5 mM 4.54 mL 22.7 mL 45.39 mL
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10043
作用机制 Inhibitor (抑制剂)
M. Wt 440.6
Formula C27H32N6
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 497839-62-0
Synonyms AEE-788, NVP-AEE788
SMILES CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4N[C@H](C)C5=CC=CC=C5

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