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NSC59984通过MDM2和泛素蛋白酶体途径诱导突变p53蛋白降解。大多数癌细胞中NSC59984的EC50明显低于正常细胞，p53-null HCT116细胞的EC50为8.38 uM。
靶点信息
| p53 | ||||
| In vitro | DMSO | 48 mg/mL (180.94 mM) | |
| Water | Insoluble | ||
| Ethanol | 48 mg/mL (180.94 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.7 mL | 188.49 mL | 376.97 mL |
| 0.5 mM | 7.54 mL | 37.7 mL | 75.39 mL |
| 1 mM | 3.77 mL | 18.85 mL | 37.7 mL |
| 5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
*The above data is based on the productmolecular weight 265.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13413 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 265.27 |
| Formula | C12H15N3O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 803647-40-7 |
| Synonyms | NSC 59984, NSC-59984 |
| SMILES | CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-] |
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