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搜索结果：“Lurasidone HCl”

“Lurasidone HCl”的搜索结果

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Blasticidin S HCl

Catalog No. A14212
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Blasticidin S HCl是一种分离自gistreochromogenes链霉菌的核苷抗生素，并充当DNA和蛋白质合成抑制剂。了解更多

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Idarubicin HCl

Catalog No. A10465
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Topoisomerase 抑制剂

Idarubicin HCl是蒽环类抗生素，是一种比柔红霉素具有更高DNA结合能力和更大细胞毒性的抗白血病药物。了解更多

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- Wei Y, .et al. SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage, Mol Cell, 2017, Jun 1;66(5):581-596.e6 PMID: 28552615
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Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

Catalog No. A10194
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Topoisomerase 抑制剂

Cerubidine (Daunorubicin HCl,Rubidomycin HCl)通过插入和抑制大分子生物合成与DNA相互作用。这抑制了拓扑异构酶II的进程，该酶使DNA中的超螺旋松弛以进行转录。了解更多

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Topotecan HCl (Hycamtin)

Catalog No. A10939
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DNA topoisomerase I 抑制剂

Topotecan HCl (Hycamtin)是一种化学治疗剂，是拓扑异构酶抑制剂。了解更多

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Gemcitabine HCl (Gemzar)

Catalog No. A10423
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DNA/RNA Synthesis 抑制剂

Gemcitabine HCl (Gemzar)是一种DNA synthesis抑制剂，作用于PANC1，MIAPaCa2，BxPC3和Capan2细胞，通过在癌细胞dna复制过程中取代核酸的一个组成部分，防止肿瘤生长。了解更多

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- G. R. Iglesias, .et al. Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles, Polymers, 2018, 10(3), 269
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Tubastatin A HCl

Catalog No. A11042
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HDAC6 抑制剂

Tubastatin A HCl是一种有效的选择性HDAC6抑制剂，在无细胞试验中IC50为15 nM。它对除HDAC8（57倍）以外的所有其他同工酶（1000倍）具有选择性。了解更多

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- Isin Cakir, .et al. Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity, Nat Metab, 2022, Jan;4(1):44-59 PMID: 35039672
- Isin Cakir, .et al. Sulforaphane reduces obesity by reversing leptin resistance, Elife, 2022, Mar 24 PMID: 35323110
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Moxifloxacin HCl

Catalog No. A10609
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Topoisomerase 抑制剂

Moxifloxacin HCl是一种喹诺酮/氟喹诺酮类抗菌剂。了解更多

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- Hiroshi Arakawa, .et al. Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs, Biopharm Drug Dispos, 2016, Jan;37(1):39-45 PMID: 26590007
- Arisa Higa, .et al. Differing responses of human stem cell-derived cardiomyocytes to arrhythmogenic drugs, determined using impedance measurements, Fundam. Toxicol. Sci, 2016, 3(2): 47-53
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Irinotecan HCl Trihydrate (Campto)

Catalog No. A10479
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Topoisomerase 抑制剂

Irinotecan (CPT 11)是喜树碱家族的一种化合物，是参与细胞DNA复制和转录的拓扑异构酶1的抑制剂。了解更多

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Puromycin 2HCl

Catalog No. A14268
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protein synthesis 抑制剂

Puromycin 2HCl是一种氨基核苷抗生素，可作为蛋白质合成抑制剂。了解更多

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TAS 103 2HCl

Catalog No. A14141
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topoisomerase I/II 抑制剂

TAS 103 2HCl，也称为BMS-247615，是一种喹啉衍生物，在鼠和人肿瘤模型中显示出抗肿瘤活性。了解更多

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Bendamustine HCl (SDX-105)

Catalog No. A10124
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Bendamustine Hydrochloride (SDX-105)是一种小分子双功能DNA烷基化剂，结合了氮芥菜碱功能和嘌呤类似物结构。苯达莫司汀具有致密的破坏DNA的功能，使其与用作抗增殖剂的其他化合物区分开来，这些功能被认为可通过多种不同途径（包括凋亡和有丝分裂灾难）促进细胞死亡。了解更多

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AN3365

Catalog No. A16329
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leucyl-tRNA synthetase 抑制剂

AN3365是一种有效的，选择性的亮氨酰tRNA合成酶抑制剂。了解更多

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Mitoxantrone Hydrochloride

Catalog No. A10596
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Mitoxantrone Dihydrochloride是一种抗病毒，抗菌，抗原生动物，免疫调节和抗肿瘤细胞抑制性蒽醌衍生物。了解更多

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Sarafloxacin HCl

Catalog No. A11659
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Topoisomerase 抑制剂

Sarafloxacin hydrochloride是氟喹诺酮类抗菌剂。抑制细菌DNA促旋酶（拓扑异构酶）。了解更多

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Epirubicin HCl

Catalog No. A10345
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Topoisomerase II 抑制剂

Epirubicin HCl是一种可透过细胞的蒽环类抗肿瘤抗生素。它用于抑制拓扑异构酶II和DNA解旋酶活性。了解更多

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SRT1720 HCl

Catalog No. A10862
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SIRT1 Activator

SRT1720 HCl是一种抑制剂，旨在作为瑟土因亚型SIRT1的小分子活化剂。了解更多

Product Citations (7)

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- Eleni Pitsillou, .et al. Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay, Comput Biol Chem, 2020, 89: 107408 PMID: 33137690
- Jie Ren, .et al. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice, Sleep Breath, 2018, Nov 8 PMID: 30411173
- Rowlands BD, .et al. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation, J Neurochem, 2017, Mar;140(6):903-918 PMID: 27925207
- Adam Khader, .et al. SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis, J Surg Res, 2017, Nov;219:288-295 PMID: 29078895
- Adam Khader, .et al. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy, Crit Care Med, 2016, Aug; 44(8): e651-e663 PMID: 26963320
- Benjamin D. Rowlands, .et al. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism., J Neurosci Res., 2015, Jul;93(7):1147-56 PMID: 25677687
- Khader A, .et al. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion., Transplantation, 2014, 98(2):148-56 PMID: 24918615

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