“jwh 249”的搜索结果

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  1. Vaborbactam

    Catalog No. A20638
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    β-lactamase inhibitor
    Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor. 了解更多
  2. p38-α MAPK-IN-1

    Catalog No. A21036
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    MAPK14 inhibitor
    p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay. 了解更多
  3. Indotecan

    Catalog No. A20979
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    Top1 inhibitor
    Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. 了解更多
  4. ISA-2011B

    Catalog No. A20960
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    PIP5K?? inhibitor
    ISA-2011B is a PIP5Kα inhibitor with promising anticancer effects . 了解更多
  5. TCS 401

    Catalog No. A21859
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    PTP1B inhibitor
    TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). 了解更多
  6. Pyr6

    Catalog No. A21927
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    TRPC3 inhibitor
    Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells). 了解更多
  7. K-604 dihydrochloride

    Catalog No. A21773
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    ACAT-1 inhibitor
    K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45??0.06 μM. 了解更多
  8. ML216

    Catalog No. A21754
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    BLM helicase inhibitor
    ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 μM and 0.97 μM for BLMfull-length and BLM636-1298, respectively. 了解更多
  9. HSP70-IN-1

    Catalog No. A21716
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    HSP inhibitor
    HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. 了解更多
  10. D8-MMAE

    Catalog No. A21709
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    mitotic/tubulin inhibitor
    D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor. 了解更多
  11. Bay 41-4109 less active enantiomer

    Catalog No. A21681
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    HBV inhibitor
    Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. 了解更多
  12. MKC9989

    Catalog No. A21602
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    Hydroxy aryl aldehydes (HAA) inhibitor
    MKC9989 is a Hydroxy aryl aldehydes (HAA) inhibitor and also inhibits IRE1α with an IC50 of 0.23 to 44 μM. 了解更多
  13. PE859

    Catalog No. A21592
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    Tau and Aβ aggregation inhibitor
    PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. 了解更多
  14. Sch-42495 racemate

    Catalog No. A21408
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    NEP inhibitor
    Sch-42495 racemate is the racemate of Sch-42495. Sch-42495 is a novel neutral metalloendopeptidase (NEP) inhibitor. Sch-42495 is the orally active ethylester prodrug of SCH 42354. 了解更多
  15. (R)-Zanubrutinib

    Catalog No. A21342
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    BTK inhibitor
    (R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor. 了解更多
  16. Gepotidacin

    Catalog No. A21086
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    topoisomerase II inhibitor
    Gepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. 了解更多
  17. RR6

    Catalog No. A21054
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    vanin inhibitor
    RR6 is a selective, reversible, and competitive vanin inhibitor. 了解更多
  18. EL-102

    Catalog No. A20925
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    HIF1α inhibitor
    EL102 is a inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability. 了解更多
  19. Avibactam sodium

    Catalog No. A17306
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    non-β-lactam β-lactamase inhibitor
    Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively. 了解更多
  20. Apatinib

    Catalog No. A17249
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    tyrosine kinase inhibitor
    Apatinib (YN968D1) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 with an IC50 of 1 nM. 了解更多
  21. Talabostat

    Catalog No. A14079
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    DPP-IV inhibitor
    Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM). 了解更多
  22. MBP146-78

    Catalog No. A12491
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    PKG inhibitor
    MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases. 了解更多
  23. DprE1-IN-2

    Catalog No. A12495
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    DprE1 inhibitor
    DprE1-IN-2 (compound 18) is a potent DprE1 inhibitor with an IC50 of 28 nM. DprE1-IN-2 has antituberculosis effect. 了解更多
  24. BCR-ABL-IN-1

    Catalog No. A12496
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    BCR-ABL inhibitor
    BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia. 了解更多
  25. MBM-17

    Catalog No. A12499
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    Nek2 inhibitor
    MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. 了解更多
  26. Norverapamil hydrochloride

    Catalog No. A12249
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    P-gp inhibitor
    Norverapamil hydrochloride ((??)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. 了解更多
  27. SID 3712249

    Catalog No. A12286
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    miR-544 inhibitor
    SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). 了解更多
  28. BAY885

    Catalog No. A13765
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    ERK5 inhibitor
    BAY885 is a novel ERK5 inhibitor. 了解更多
  29. 4E2RCat

    Catalog No. A12337
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    eIF4E-eIF4G interaction inhibitor
    4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. 了解更多
  30. MD2-TLR4-IN-1

    Catalog No. A18452
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    MD2-TLR4 inhibitor
    MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. 了解更多
  31. PROTAC MDM2 Degrader-4

    Catalog No. A18877
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    MDM2 inhibitor
    PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多
  32. PROTAC MDM2 Degrader-2

    Catalog No. A18890
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    MDM2 inhibitor
    PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多
  33. Syncytial Virus Inhibitor-1

    Catalog No. A19053
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    RSV fusion inhibitor
    Syncytial Virus Inhibitor-1 is a potent, orally bioavailable respiratory syncytial virus (RSV) fusion inhibitor with EC50s of 0.002 μM, 0.004 μM, and 0.002 μM for RSV Long, RSV A2, and RSV B strains, respectively. 了解更多
  34. BJE6-106

    Catalog No. A18627
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    PKCδ inhibitor
    BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). 了解更多
    • 最新产品

    NPI64

    Catalog No. A17220
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    Protease inhibitor
    NPI64 is a broad-spectrum coronavirus protease inhibitor which inhibits viral 3C and 3C-like protease. 了解更多
  35. Nedisertib

    Catalog No. A17055
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    DNA-PK 抑制剂
    Nedisertib (M-3814,MSC2490484A)是一种可口服的DNA依赖性蛋白激酶(DNA-PK)抑制剂,具有潜在的抗肿瘤和化学/放射增敏活性。 了解更多
  36. Azacosterol

    Catalog No. A13295
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    24-DHCR 抑制剂
    Azacosterol可作为24-脱氢胆固醇还原酶(24-DHCR)的抑制剂,可防止去甾醇形成胆固醇。 了解更多
  37. FLT3-IN-1

    Catalog No. A16249
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    FLT3 抑制剂
    FLT3-IN-1是一种新型的有效选择性Flt3抑制剂,IC50为10 nM。抗表达FLT3-ITD的MV4-11细胞,IC50为6 nM。 了解更多
  38. Diflunisal

    Catalog No. A16166
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    COX 抑制剂
    Diflunisal是具有止痛和抗炎活性的水杨酸衍生物。 了解更多
  39. ALW-II-41-27

    Catalog No. A12493
    Eph receptor 抑制剂
    ALW-II-41-27是新型的Eph受体酪氨酸激酶抑制剂。 了解更多
  40. AMG 548

    Catalog No. A10970
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    p38 MAPK 抑制剂
    AMG 548是有效的p38α选择性抑制剂。它对其他36种激酶表现出> 1000倍的选择性,并且抑制全血LPS刺激的TNFα。 了解更多
  41. NG52

    Catalog No. A12494
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    Cell cycle-regulating kinase 抑制剂
    NG52 (Compound 52)是细胞周期调节激酶Cdc28p(IC50 = 7 μM)和相关Pho85p激酶(IC50 = 2 μM)的有效,可渗透细胞,可逆,选择性和ATP兼容的抑制剂。 了解更多
  42. NFAT Inhibitor

    Catalog No. A15381
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    NFAT 抑制剂
    NFAT Inhibitor是钙调神经磷酸酶介导的活化T细胞核因子(NFAT)的去磷酸化的选择性抑制剂。 了解更多
  43. CEP-32496 hydrochloride

    Catalog No. A15040
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    Raf 抑制剂
    CEP-32496 hydrochloride是野生型BRAF,V600E突变型BRAF和c-Raf的高效抑制剂,Kd值分别为14 nM,36 nM和39 nM。 了解更多
  44. TNP-470

    Catalog No. A14014
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    MetAP-2 抑制剂
    TNP 470是富马西林的类似物,在体外显示有效的抗血管生成活性。已显示出抑制MetAP-2(甲硫氨酸氨基肽酶II型)的作用。 了解更多
  45. CEP-32496

    Catalog No. A13772
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    Raf 抑制剂
    CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1(B-raf)丝氨酸/苏氨酸蛋白激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多
  46. PFK-158

    Catalog No. A14398
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    PFK-2/FBPase 抑制剂
    PFK-158是6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶(PFK-2/FBPase)同工型3(PFKFB3)的抑制剂,是3-(3-吡啶基)-1-[4-吡啶基]-2-丙烯-1-酮(3PO),具有潜在的抗肿瘤活性。 了解更多
  47. SH-4-54

    Catalog No. A14249
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    Stat 抑制剂
    SH-4-54是一种有效的STAT抑制剂,对STAT3和STAT5的KD为300 nM和464 nM。 了解更多
  48. Pirarubicin

    Catalog No. A10735
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    Topoisomerase II 抑制剂
    Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II(拓扑异构酶II)相互作用并抑制DNA复制。 了解更多
  49. SNS-314

    Catalog No. A10851
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    Aurora 抑制剂
    SNS-314 Mesylate是Aurora A,Aurora B和Aurora C的有效和选择性抑制剂,IC50分别为9 nM,31 nM和3 nM。 它对Trk A/B,Flt4,Fms,Axl,c-Raf和DDR2的效力较低。 阶段1。 了解更多

产品 1 到 50 共 52个

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