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Paprotrain
Catalog No. A20346 MKLP-2 inhibitorPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM. 了解更多 -
Tazanolast
Catalog No. A20296 Tazanolast is a selective mast-cell-stabilizing drug, on ozone-induced airway hyperresponsiveness in guinea pigs. 了解更多 -
Dexanabinol
Catalog No. A20290 Dexanabinol exhibits not only the antioxidant and neuroprotective activities in brain but also anti-inflammatory activity by inhibiting NF-κB and decreasing cytokines such as TNFα and interleukin-6, which could ensure the integrity of BBB and reduce cell apoptosis and death. 了解更多 -
Valemetostat
Catalog No. A20269 EZH1/2 dual inhibitorValemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, used in the research of relapsed/refractory peripheral T-cell lymphoma. 了解更多 -
Tefinostat
Catalog No. A20258 pan HDAC inhibitorTefinostat (CHR-2845) is a monocyte/macrophage-targeted pan HDAC inhibitor, cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Anti-monocytoid lineage leukaemias activity. 了解更多 -
Recilisib (free acid)
Catalog No. A20255 radioprotectantRecilisib is a radioprotectant, which can activate AKT, PI3K activities in cells. 了解更多 -
JH-VIII-157-02
Catalog No. A20205 ALK inhibitorJH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. 了解更多 -
DC1SMe
Catalog No. A20181 DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. 了解更多 -
(S,R,S)-AHPC-PEG6-C4-Cl
Catalog No. A20169 (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. 了解更多 -
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl
Catalog No. A20157 (S,R,S)-AHPC-(C3-?PEG)?2-?C6-?Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3-?PEG)?2-?C6-?Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. 了解更多 -
STAT5-IN-2
Catalog No. A20126 STAT5 inhibitorSTAT5-IN-2 is a STAT5 inhibitor with EC50s of 9 μM and 5 μM in K562 and KU812 cells, respectively. Potent antileukemic effect. 了解更多 -
TMPyP4 tosylate
Catalog No. A20124 telomerase inhibitorTMPyP4 tosylate (TMP 1363) is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines. 了解更多 -
5α-Pregnane-3β,6α-diol-20-one
Catalog No. A20118 5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells. 了解更多 -
IL-15-IN-1
Catalog No. A20113 IL-15 inhibitorIL-15-IN-1 is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. 了解更多 -
Hsp90-Cdc37-IN-1
Catalog No. A20095 Hsp90-Cdc37 interaction disruptorsHsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance, with an IC50 of 140 nM. 了解更多 -
Fosfructose
Catalog No. A20085 Fosfructose (Diphosphofructose;Esafosfan;FDP) is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma. 了解更多 -
mTOR inhibitor-1
Catalog No. A20029 mTOR inhibitormTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy. 了解更多 -
BRD4 degrader AT1
Catalog No. A19956 Brd4 degraderBRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells. 了解更多 -
S-methyl-KE-298
Catalog No. A19954 S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. 了解更多 -
ML 145
Catalog No. A19953 GPR35/CXCR8 antagonistML 145 is a selective GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM, but not for the related GPR55 orphan receptor. GPR35 is expressed by various cells of the immune system and it may has potential as a therapeutic target in inflammatory disease. 了解更多 -
Leelamine hydrochloride
Catalog No. A19910 CB1 agonistLeelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. 了解更多 -
EPAC 5376753
Catalog No. A19890 Epac inhibitorEPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 ?M in Swiss 3T3 cells. 了解更多 -
AHR antagonist 1
Catalog No. A19881 AHR antagonistAHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2017202816A1, example 23, has an IC50 of 39.9 nM in human cell line. 了解更多 -
GR 159897
Catalog No. A19862 NK2 antagonistGR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide antagonist at tachykinin NK2 receptors, inhibits binding of [3H]GR100679 to hNK2-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction, with anxiolytic-like activity. 了解更多 -
CGP71683 hydrochloride
Catalog No. A19844 neuropeptide Y5 receptor antagonistCGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes. 了解更多 -
Acridine Orange hydrochloride
Catalog No. A19835 fluorescent dyeAcridine Orange hydrochloride is a cell-permeable fluorescent dye that binds to nucleic acids, resulting in an altered spectral emission. 了解更多 -
Guggulsterone
Catalog No. A19825 Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. 了解更多
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