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KDM2A/7A-IN-1
Catalog No. A19724 KDM2A/7A inhibitorKDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16?μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases. 了解更多 -
PI3Kγ inhibitor 2
Catalog No. A19606 PI3Kγ inhibitorPI3Kγ inhibitor 2 (Compound 16) is an orally bioavailable, CNS-penetrant, isoform selective PI3Kγ inhibitor with a Ki of 4 nM. 了解更多 -
DS-1040 Tosylate
Catalog No. A19600 TAFIa inhibitorDS-1040 Tosylate is an inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa), used for the treatment of acute ischemic stroke (AIS). 了解更多 -
ERK1/2 inhibitor 1
Catalog No. A19596 ERK1/2 inhibitorERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively. 了解更多 -
(S,R,S)-AHPC TFA
Catalog No. A19593 (S,R,S)-AHPC TFA (MDK7526 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA (MDK7526 TFA) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. 了解更多 -
Anti-Heart Failure Agent 1
Catalog No. A19583 Anti-Heart Failure Agent 1 an orally available compound suitable for the treatment of heart failure without inducing nausea, vomiting and restlessness. 了解更多 -
Cyclophilin inhibitor 1
Catalog No. A19577 cyclophilin A inhibitorCyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin A inhibitor, with a Kd of 5 nM, shows effective anti-HCV activity, with an EC50 of 98 nM for HCV 2a. 了解更多 -
BAY-678 racemate
Catalog No. A19564 HNE inhibitorBAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). 了解更多 -
DS88790512
Catalog No. A19551 TRPC6 inhibitorDS88790512 is a potent, selective, and orally bioavailable TRPC6 inhibitor with an IC50 of 11 nM. 了解更多 -
BMS-816336
Catalog No. A19528 11β-HSD1 inhibitorBMS-816336 is a novel, potent and orally bioavailable inhibitor against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with an IC50 of 3.0 nM. 了解更多 -
Ripretinib
Catalog No. A19508 KIT and PDGFRA switch-control inhibitorRipretinib (DCC-2618) is an orally bioavailable, selective KIT and PDGFRA switch-control inhibitor. 了解更多 -
Avapritinib
Catalog No. A19505 KIT and PDGFRA inhibitorAvapritinib (BLU-285) is a highly potent, selective, and orally bioavailable KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. 了解更多 -
BAY-1895344
Catalog No. A19454 ATR inhibitorBAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity. 了解更多 -
CXCR7 modulator 1
Catalog No. A19428 CXCR7 modulatorCXCR7 modulator 1 (compound 25) is a potent and orally bioavailable peptoid hybrid CXCR7 modulator, with a Ki of 9 nM. 了解更多 -
Velagliflozin
Catalog No. A19404 SGLT2 inhibitorVelagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity. 了解更多 -
Mirogabalin besylate
Catalog No. A19379 ligand for the α2δ subunit of voltage-gated calcium channelsMirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively. 了解更多 -
AcLys-PABC-VC-Aur0101
Catalog No. A19371 drug-linker conjugate for ADCAcLys-PABC-VC-Aur0101 is a drug-linker conjugate for ADC (anti-CXCR4 ADC) with potent antitumor activity by using Aur0101 (an auristatin microtubule inhibitor), linked via the cleavable linker AcLys-PABC-VC. 了解更多 -
AmPEG6C2-Aur0131
Catalog No. A19363 drug-linker conjugate for ADCAmPEG6C2-Aur0131 is a drug-linker conjugate for ADC (anti-CXCR4 ADC) with potent antitumor activity by using Aur0131 (an auristatin microtubule inhibitor), linked via the non-cleavable linker AmPEG6C2. 了解更多 -
Firuglipel
Catalog No. A19344 GPR119 agonistFiruglipel (DS-8500a) is an orally available, potent and selective GPR119 agonist. 了解更多 -
(+)-JQ1 PA
Catalog No. A19328 BET bromodomain inhibitor(+)-JQ1 PA is a clickable JQ1 for building PROTACs, which acts as a BET bromodomain inhibitor. 了解更多 -
c-Met-IN-2
Catalog No. A19302 c-Met inhibitorc-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC50 of 0.6 nM, with antitumor activity. 了解更多 -
GSK-626616
Catalog No. A19273 DYRK3 inhibitorGSK-626616 is a potent, orally bioavailable inhibitor of DYRK3 (IC50=0.7 nM). 了解更多 -
Tulrampator
Catalog No. A19266 Tulrampator (CX-1632) is an orally bioavailable positive AMPAR (allosteric modulator of AMPA receptor). Antidepressant. 了解更多 -
PI3Kdelta inhibitor 1
Catalog No. A19249 PI3Kδ inhibitorPI3Kdelta inhibitor 1 (Compound 5d) is a potent, selective and orally available PI3Kδ inhibitor with an IC50 of 1.3 nM. 了解更多 -
PF-06869206
Catalog No. A19239 SLC34A1 inhibitorPF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. 了解更多 -
Nomegestrol
Catalog No. A19235 full progesterone receptor agonistNomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity. 了解更多 -
NE 52-QQ57
Catalog No. A19231 GPR4 antagonistNE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. Anti-inflammatory activities. 了解更多 -
Elenbecestat
Catalog No. A19223 BACE-1 inhibitorElenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant BACE-1 inhibitor for the treatment of Alzheimer's disease (AD). 了解更多 -
PI3Kγ inhibitor 3
Catalog No. A19206 PI3Kγ inhibitorPI3Kγ inhibitor 3 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively. 了解更多 -
Fulacimstat
Catalog No. A19202 chymase inhibitorFulacimstat is an orally available chymase inhibitor, with IC50s of 4, 3 nM for human and hamster chymase enzyme, respectively. 了解更多 -
Petroselinic acid
Catalog No. A19183 Petroselinic acid, a positional isomer of oleic acid, is isolated from the vegetable oil of Coriandrum sativum fruits. 了解更多 -
MC-Alkyl-Hydrazine Modified MMAF
Catalog No. A19179 MC-Alkyl-Hydrazine Modified MMAF is a drug-linker conjugate for ADC with potent antitumor activity by using the Modified MMAF (a tubulin inhibitor), linked via the noncleavable MC-Alkyl-Hydrazine. 了解更多 -
Autotaxin-IN-1
Catalog No. A19164 autotaxin inhibitorAutotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain. 了解更多 -
PEG4-aminooxy-MMAF
Catalog No. A19160 PEG4-aminooxy-MMAF is a drug-linker conjugate for ADC with potent antitumor activity by using the potent antitubulin agent MMAF, linked via the noncleavable PEG4. 了解更多 -
Fmoc-Phe-Lys(Boc)-PAB-PNP
Catalog No. A19151 Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 了解更多
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