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HCV NS4 a+b Rhodamine
Catalog No. AP6082 Hepatitis C Virus NS4 a+b Rhodamine Labeled Recombinant 了解更多 -
Avitinib (AC0010)
Catalog No. A16826 irreversible EGFR 抑制剂Avitinib (AC0010)是一种基于吡咯并嘧啶的不可逆EGFR抑制剂，对EGFR L858R/T790M双重突变具有突变选择性，IC50值为0.18 nM，效力比野生型EGFR（IC50值为7.68 nM）高近43倍。它具有可比的抗肿瘤活性和耐受的毒性。 了解更多 -
ABBV-744
Catalog No. A16831 -
Glecaprevir
Catalog No. A16948 HCV NS3/4A protease 抑制剂Glecaprevir，也称为ABT-493和A-1282576，是一种新型的HCV NS3/4A蛋白酶抑制剂，IC50值在3.5至11.3 nM之间。 了解更多 -
ABX-464
Catalog No. A16912 -
Desformylflustrabromine HCl
Catalog No. A17103 Desformylflustrabromine HCl是α4β2的正变构调节剂，也是肌肉型nAChR抑制剂。 了解更多 -
(-)-Securinine
Catalog No. A17102 GABA receptor 拮抗剂(-)-Securinine是一种最初从S. suffructicosa分离的生物碱。Securinine是一种特定的GABA受体拮抗剂，已发现在体内具有显着的CNS活性。 了解更多 -
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最新产品
YHO-13177
Catalog No. A17127 -
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Vecabrutinib
Catalog No. A17189 -
Abiraterone metabolite 1
Catalog No. A16992 Abiraterone metabolite 1是abiraterone的5β还原代谢产物。类固醇药物abiraterone可抑制CYP17A1，阻断雄激素的合成并延长前列腺癌的生存期。 了解更多 -
CMP3a
Catalog No. A18347 NEK2 kinase inhibitorCMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. 了解更多 -
Chlorthalidone
Catalog No. A17253 Chlorthalidone is a diuretic drug used to treat hypertension. It is described as a thiazide diuretic. Compared with other medications of the thiazide class, chlortalidone has the longest duration of action but a similar diuretic effect at maximal therapeutic doses. Chlortalidone is often used in the management of hypertension and edema. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in sodium, chloride, bicarbonate, and potassium secretion resulting in the excretion of water. 了解更多 -
Afloqualone
Catalog No. A17276 GABA receptor agonistAfloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site. 了解更多 -
Vitamin E Acetate
Catalog No. A17284 D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine. 了解更多 -
Ethopabate
Catalog No. A17296 folate metabolism inhibitorEthopabate is a folate metabolism inhibitor used in the prophylaxis and treatment of coccidiosis in chickens. 了解更多 -
Harmine
Catalog No. A17316 Harmine, also known as telepathine, is a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds. It occurs in a number of different plants, most notably the Middle Eastern plant harmal or Syrian rue (Peganum harmala) and the South American vine Banisteriopsis caapi (also known as "yage" or "ayahuasca"). Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a RIMA. Harmine selectively binds to MAO-A but does not inhibit the variant MAO-B. 了解更多 -
Pyrogallol
Catalog No. A17318 Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions. 了解更多 -
L-Cycloserine
Catalog No. A17324 L-Cycloserine ((S)-4-Amino-3-isoxazolidone) irreversibly inhibits GABA pyridoxal 5??-phosphate-dependent aminitransferase in E. 了解更多 -
(-)-Borneol
Catalog No. A17334 (-)-Borneol is a bicyclic organic compound and a terpene derivative. The hydroxyl group in this compound is placed in an endo position. There are two different enantiomers of borneol. (-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM. 了解更多 -
(+)-α-Lipoic acid
Catalog No. A17343 Lipoic Acid, also known as R-(+)-alpha-Lipoic acid, is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism. It is also manufactured and is available as a dietary supplement in some countries where it is marketed as an antioxidant, and is available as a pharmaceutical drug in other countries. 了解更多 -
Oxprenolol HCl
Catalog No. A17368 Non-selective β antagonistOxprenolol is an orally bioavailable β-adrenergic receptor (β-AR) antagonist (Ki = 7.10 nM in a radioligand binding assay using rat heart tissue). It is non-selective and inhibits both β1- and β2-ARs (Kds = 2.09 and 1.35 nM in isolated rat heart and uterus, respectively). Oxprenolol is selective for β-ARs over serotonin (5-HT) receptors in rat sarcolemmal membrane preparations (IC50s = 4.13 and 23,300 nM, respectively), but it binds to 5-HT1A receptors in rat hippocampus and 5-HT1B in rat striatum (Kis = 94.2 and 642 nM, respectively). 了解更多 -
Bendroflumethiazide
Catalog No. A17389 Bendroflumethiazide is a thiazide diuretic used to treat hypertension. Bendroflumethiazide works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule and may play an important role in the treatment of mild heart failure. 了解更多 -
Bentiromide
Catalog No. A17390 Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. 了解更多 -
Picrotoxinin
Catalog No. A17400 Picrotoxinin negatively modulate the action of GABA on GABAA receptors. 了解更多 -
Misoprostol
Catalog No. A17401 Misoprostol is a medication used to start labor, cause an abortion, prevent and treat stomach ulcers, and treat postpartum bleeding due to poor contraction of the uterus. For abortions it is often used with mifepristone or methotrexate. By itself effectiveness for this purpose is between 66% and 90%. 了解更多 -
Dithranol
Catalog No. A17404 Anthralin, also known as Dithranol, is a hepsin activity inhibitor used for treatment of psoriasis Inhibition of hepsin activity suppresses the invasive growth of the tumor. Anthralin exerts a direct effect on keratinocytes and leukocytes. Anthralin significantly prolonged the prophase of mitotic keratinocytes in subtoxic doses and suppressed the expression of keratin 6 mRNA in the immediately suprabasal layer of psoriatic epidermis in vivo. Anthralin also inhibits the transformation of lymphocytes and the release of reactive oxygen species from activated leukocytes, in vitro. 了解更多 -
(+)-α-Tocopherol
Catalog No. A17407 alpha-Tocopherol is one of the most abundant isoforms of vitamin E. alpha-Tocopherol is a biologically active liposoluble vitamin and potent antioxidant. 了解更多
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