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Epigenetics

Epigenetics

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R306465

Catalog No. A15437
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HDAC 抑制剂

R306465是一种新型的基于异羟肟酸酯的组蛋白脱乙酰基酶（HDAC）抑制剂，在临床前模型中具有针对实体和血液恶性肿瘤的广谱抗肿瘤活性。了解更多

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- Mari Ishigami-Yuasa, .et al. Class IIb HDAC Inhibition Enhances the Inhibitory Effect of Am80, a Synthetic Retinoid, in Prostate Cancer, Biol Pharm Bull, 2019, 42, 448-452
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M344

Catalog No. A11355
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HDAC 抑制剂

M344是HDAC的有效抑制剂，IC50为100 nM，能够诱导细胞分化。了解更多

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ITSA-1

Catalog No. A16127
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HDAC 抑制剂

ITSA-1具有膜渗透性，可以特异性抑制TSA对HDAC（组蛋白脱乙酰基酶）的抑制，但不能抑制其他HDAC抑制剂。了解更多

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BML-210

Catalog No. A15935
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HDAC 抑制剂?

BML-210是HDAC抑制剂。BML-210诱导宫颈癌细胞中的生长抑制和凋亡并调节HDAC和DAPC复合物的表达水平。了解更多

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Valproic acid

Catalog No. A17323
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HDAC inhibitor

Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. 了解更多

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- Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
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Splitomicin

Catalog No. A14221
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NAD(+)-dependent histone deacetylase Sir2p 抑制剂

Splitomicin是一种选择性的NAD(+)-依赖性组蛋白脱乙酰基酶Sir2p抑制剂，IC50为60 uM，在基于细胞的测定中显示出更高的活性。了解更多

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HDAC inhibitor

Catalog No. A13405
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HDAC 抑制剂

N/A 了解更多

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ST7612AA1

Catalog No. A14418
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HDAC 抑制剂

ST7612AA1是新型的有效HDAC抑制剂，具有潜在的抗癌活性。了解更多

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PCI-24781 (Abexinostat)

Catalog No. A10700
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HDAC 抑制剂

PCI-24781 (Abexinostat)是一种广谱苯基异羟肟酸HDAC抑制剂。了解更多

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Scriptaid

Catalog No. A12722
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HDAC 抑制剂

Scriptaid是一种HDAC抑制剂（组蛋白脱乙酰基酶）。了解更多

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Vorinostat (SAHA)

Catalog No. A10979
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HDAC 抑制剂

Vorinostat (SAHA)是HDAC的抑制剂，抑制脱乙酰和导致双方超乙酰化组蛋白和转录因子的积累。了解更多

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- Ting-Yu Chang, .et al. A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling, Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521
- David Diaz-Carballo, .et al. Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors, Commun Biol, 2021, Mar 3;4(1):276 PMID: 33658617
- Arshdeep Singh, .et al. CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition, Eur J Med Chem, 2021, Apr 5;215:113169 PMID: 33588178
- Shariful Islam, .et al. Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy, Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458
- Giovanni Bocci, .et al. Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19, ACS Pharmacol Transl Sci, 2020, Oct 14
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LAQ824 (NVP-LAQ824, Dacinostat)

Catalog No. A10516
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HDAC 抑制剂

LAQ824 (NVP-LAQ824)是一种有效的新型组蛋白去乙酰化酶抑制剂，具有显著的抗多发性骨髓瘤活性。了解更多

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- De-Run Chen, .et al. Engineered nanogels simultaneously implement HDAC inhibition and chemotherapy to boost antitumor immunity via pyroptosis, Appl Mater Today, 2022, 26: 101363
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NCH 51

Catalog No. A15355
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HDAC 抑制剂

NCH 51是细胞可渗透的前药，可在细胞内转化为有效的HDAC抑制剂，IC50为48 nM。了解更多

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Belinostat (PXD101)

Catalog No. A10122
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HDAC 抑制剂

Belinostat（PXD101）是一种HDAC抑制剂，可抑制HeLa细胞提取物中的HDAC活性，IC50为27 nM。了解更多

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- Shariful Islam, .et al. Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy, Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458
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SB939 ( Pracinostat )

Catalog No. A10830
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HDAC 抑制剂

SB939 (Pracinostat)是HDAC的口服抑制剂，对I，II和IV类HDAC具有选择性，在体外HDAC1活性测定中显示IC50值为77 nM。了解更多

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- Giovanni Bocci, .et al. Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19, ACS Pharmacol Transl Sci, 2020, Oct 14
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AR-42 (HDAC-42)

Catalog No. A11037
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HDAC 抑制剂

AR-42 (HDAC-42)是一种新型的HDAC抑制剂，通过下调本构激活的Kit表现出对恶性肥大细胞系的生物学活性。了解更多

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- Yong-Hui Liao, .et al. Histone deacetylase 2 is involved in μ-opioid receptor suppression in the spinal dorsal horn in a rat model of chronic pancreatitis pain, Mol Med Rep, 2018, Feb; 17(2): 2803-2810 PMID: 29257262
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Apicidin

Catalog No. A12745
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HDAC 抑制剂

Apicidin是一种有效的组蛋白脱乙酰基酶（HDAC）抑制剂，具有潜在的抗癌活性。了解更多

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NSC 3852

Catalog No. A15356
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HDAC 抑制剂

NSC 3852是HDAC（组蛋白脱乙酰基酶）抑制剂。了解更多

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CUDC-101

Catalog No. A10246
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HDAC 抑制剂

CUDC-101是一种抑制多种靶标的新型化合物，旨在抑制HDAC，EGFR和Her2。了解更多

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JNJ-26481585 (Quisinostat)

Catalog No. A10492
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HDAC 抑制剂

JNJ-26481585 (Quisinostat)是一种pan-HDAC抑制剂，对HDAC1具有显著的效力(IC(50)，0.16 nmol/L)。了解更多

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- Minoru Ueda, .et al. The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response, Plant Physiol, 2017, Dec; 175(4): 1760-1773 PMID: 29018096

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