Histone Demethylases

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  1. T-448

    Catalog No. A21959
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    LSD1 inhibitor
    T-448 is a specific and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. 了解更多
  2. GSK-LSD1 dihydrochloride

    Catalog No. A21815
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    LSD1 inhibitor
    GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM. 了解更多
  3. ORY-1001(trans)

    Catalog No. A21622
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    KDM1A/LSD1 inhibitor
    ORY-1001 trans is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. 了解更多
  4. Toxoflavin

    Catalog No. A12174
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    KDM4A inhibitor
    Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity. 了解更多
  5. NCGC00244536

    Catalog No. A13025
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    KDM4B inhibitor
    NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM. 了解更多
  6. QC6352

    Catalog No. A19477
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    KDM4C inhibitor
    QC6352 is a potent KDM4C inhibitor with an IC50 of 35 nM. 了解更多
  7. T-3775440 hydrochloride

    Catalog No. A18340
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    LSD1 inhibitor
    T-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC50 value of 2.1 nM. 了解更多
  8. YUKA1

    Catalog No. A12101
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    cell permeable Lysine demethylase 5A (KDM5A) inhibitor
    YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. 了解更多
  9. GSK467

    Catalog No. A18807
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    KDM5B (JARID1B or PLU1) inhibitor
    GSK467 is a potent and selective inhibitor of KDM5 (also known as JARID1) with a Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members. GSK467 exploits unique binding modes. 了解更多
  10. CBB1007

    Catalog No. A16374
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    LSD1 抑制剂
    CBB1007是一种细胞可渗透的a基胍盐化合物,可作为有效,可逆和底物竞争性LSD1选择性抑制剂(hLSD1的IC50 = 5.27μM)。 了解更多
  11. TC-E 5002

    Catalog No. A16373
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    KDM2/7 抑制剂
    TC-E 5002是一种选择性组蛋白脱甲基酶KDM2/7亚家族抑制剂(KDM7A,KDM7B,KDM2A,KDM5A,KDM4C,KDM6A和KDM4A的IC50值分别为0.2、1.2、6.8、55、83,> 100和> 120 uM)。在体外抑制HeLa和KYSE-150癌细胞的生长。 了解更多
  12. 2,4-Pyridinedicarboxylic Acid

    Catalog No. A16372
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    KDM 抑制剂
    2,4-Pyridinedicarboxylic Acid是针对JMJD2A(KDM4A),KDM4C,KDM4E(IC50、1.4μM),KDM5B(IC50、3μM),KDM6A和 其他的2-氧合酶。 了解更多
  13. AS8351

    Catalog No. A16371
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    KDM5 抑制剂.
    AS8351是一种组蛋白脱甲基酶抑制剂。 了解更多
  14. CPI 455

    Catalog No. A16178
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    KDM5 抑制剂
    CPI 455具有用于探索KDM5依赖性疾病生物学(包括药物耐受性)的体外工具化合物所需的目标特异性。 了解更多
  15. CPI 4203

    Catalog No. A16177
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    KDM5 demethylases 抑制剂
    CPI 4203是KDM5脱甲基酶的选择性抑制剂,在结构上与CPI 455相关,但效力低约25倍(IC50值250 nM用于抑制全长KDM5A)。 了解更多
  16. CBB1003

    Catalog No. A12734
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    LSD1 抑制剂
    CBB1003是新型组蛋白脱甲基酶LSD1抑制剂,IC50为10.54 uM。 了解更多
  17. ORY-1001 (RG-6016)

    Catalog No. A15893
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    LSD1 抑制剂
    ORY-1001 (RG-6016)是一种活性的选择性赖氨酸脱甲基酶LSD1/KDM1A抑制剂,IC50 <20 nM,对相关FAD依赖性氨氧化酶具有高选择性。 了解更多
  18. ML-324

    Catalog No. A15829
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    JMJD2 抑制剂?
    ML-324是一种有效的JMJD2脱甲基酶抑制剂,具有已证明的抗病毒活性。 了解更多
  19. SP2509 (HCI-2509)

    Catalog No. A14443
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    LSD1 抑制剂
    SP2509 (HCI-2509)是一种新型组蛋白脱甲基酶LSD1(KDM1A)拮抗剂,IC50为13 nM。对MAO-A和MAO-B没有抑制作用。 了解更多
  20. GSK-J4

    Catalog No. A12732
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    Demethylase 抑制剂
    GSK J4是可被细胞吞噬的前药,可被巨噬细胞酯酶快速水解为GSK-J1,GSK-J1是一种有效的选择性Jumonji H3K27脱甲基酶抑制剂。 减轻脂多糖(LPS)诱导的人类原代巨噬细胞促炎细胞因子的产生(IC50 = 9 uM,抑制TNFα释放)。 了解更多
  21. GSK2879552

    Catalog No. A15547
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    LSD1 抑制剂
    GSK2879552是一种可逆的赖氨酸特异性脱甲基酶1(LSD1)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  22. PBIT

    Catalog No. A14366
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    JARID1 抑制剂
    PBIT是JARID1家族脱甲基酶的可逆细胞渗透性抑制剂(对于JARID1A,JARID1B,JARID1C和JARID1D而言,IC50分别为6、3、4.9和28 uM)。 了解更多
  23. IOX1

    Catalog No. A14277
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    2OG oxygenases 抑制剂
    IOX1是2OG加氧酶(包括JmjC脱甲基酶)的有效且广谱抑制剂。 了解更多
  24. JIB-04

    Catalog No. A13806
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    Histone Demethylase 抑制剂
    JIB-04是一种全选择性Jumonji组蛋白脱甲基酶抑制剂,对于JARID1A,JMJD2E,JMJD3,JMJD2A,JMJD2B,JMJD2C和JMJD2D,IC50分别为230、340、855、445、435、1100和290 nM。 了解更多
  25. LSD1-C76

    Catalog No. A12927
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    LSD1 抑制剂
    LSD1-C76是一种强效选择性赖氨酸特异性脱甲基酶-1 (LSD1)抑制剂。 了解更多
  26. GSK J1

    Catalog No. A12918
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    Histone demethylase 抑制剂
    GSK J1是H3K27组蛋白脱甲基酶JMJD3和UTX的有效和选择性抑制剂。 了解更多
  27. Tranylcypromine hydrochloride

    Catalog No. A13358
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    LSD1/BHC110 & MAO 抑制剂
    Tranylcypromine hydrochloride是一种非选择性的MAO-A/B抑制剂。 了解更多
  28. OG-L002

    Catalog No. A13246
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    LSD1 抑制剂
    OG-L002是一种有效的特异性LSD1抑制剂,IC50为20 nM,分别比MAO-B和MAO-A表现出36倍和69倍的选择性。 了解更多

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