PERK

Catalog No.Inhibitor Name PERKOther
A12792GSK2606414
****
EIF2AK1 (HRI),EIF2AK2 (PKR)
A13577GSK2656157
***
A13816ISRIB (trans-isomer)
**
A12676Salubrinal

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. ISRIB

    Catalog No. A14302
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    PERK 抑制剂
    ISRIB是一种有效的选择性PERK抑制剂,IC50为5 nM。 了解更多
  2. GSK2656157

    Catalog No. A13577
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    PERK 抑制剂
    GSK2656157是PERK酶活性的ATP竞争性抑制剂,IC50为0.9 nmol/L。 对于PER(K)IC50值> 100 nmol/L,对300种激酶组合具有高度选择性。 了解更多
  3. ISRIB (trans-isomer)

    Catalog No. A13816
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    PERK 抑制剂
    ISRIB (trans-isomer)是一种有效的选择性小分子PERK信号抑制剂(IC50?5 nM),可以有效逆转eIF2α磷酸化的作用。 了解更多
  4. GSK2606414

    Catalog No. A12792
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    PERK 抑制剂
    GSK2606414是口服有效的选择性PERK抑制剂,IC50为0.4 nM。 了解更多

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