Smoothened Receptors
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LY2940680 (Taladegib)
Catalog No. A11048 -
LDE225 Diphosphate
Catalog No. A12774 Smoothened 抑制剂LDE225 Diphosphate 是一种具有潜在抗肿瘤活性的口服生物利用小分子平滑(Smo)拮抗剂。抑制Hedgehog (Hh)信号通路,无细胞试验中IC50分别为1.3 nM (小鼠)和2.5 nM(人)。 了解更多 -
PF-5274857
Catalog No. A12775 Smoothened 抑制剂PF-5274857是一种新型Smo拮抗剂,它以4.6±1.1 nmol/L的K(i)特异性结合Smo,并以2.7±1.4 nmol/L的IC(50)完全阻断下游基因Gli1的转录活性。在细胞中。 了解更多 -
BMS-833923 (XL-139)
Catalog No. A13204 Smoothened 抑制剂BMS-833923 (XL-139)是一种生物可利用的小分子SMO(平滑)抑制剂,具有潜在的抗肿瘤活性。 了解更多 -
Glasdegib (PF-04449913)
Catalog No. A13881 -
SAG
Catalog No. A13627 -
Jervine
Catalog No. A16221 -
SAG hydrochloride
Catalog No. A21678 Smo receptor agonistSAG (hydrochloride) is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with a Kd of 59 nM. 了解更多 -
20(S)-Hydroxycholesterol
Catalog No. A21850 Smo allosteric activator20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells. 了解更多 -
LDE225 (NVP-LDE225, Sonidegib)
Catalog No. A10520 Smo 拮抗剂LDE225 (NVP-LDE225)是一种强效、选择性和口服生物可利用的平滑(SMO)拮抗剂,通过平滑受体(SMO)的拮抗作用抑制hedgehog (Hh)信号通路。 了解更多