Bcl-2 Family

Catalog No.Inhibitor Name Bcl-2Bcl-BBcl-wBcl-xLMcl-1A1BaxOther
A10255ABT-737
****
*
***
***
A10022Navitoclax (ABT-263)
****
****
****
**
**
A10665Obatoclax Mesylate
***
A10955TW-37
***
*
***
A12500Venetoclax
****
***
****
A15004AT101
**
**
***
A11448HA14-1
*
A12823Sabutoclax
**
**
***
**
A15545A-1210477
****
A14222UMI-77
**
A11988Gambogic Acid
*
*
****
*
*
*
Caspase
A12743BM-1074
****
****
A13327WEHI-539 hydrochloride
****
A15821BDA-366
***
A16061BH3I-1
*
p53
A16112A-1155463
****
A16190A-1331852
****
A16314Apogossypolone (ApoG2)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. BTSA1

    Catalog No. A16835
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    Bcl-2 modulator
    BTSA1是经过药理优化的BAX激活剂,可与N末端激活位点高亲和力和特异性结合,并诱导BAX发生构象变化,从而导致BAX介导的细胞凋亡。它有效促进白血病细胞系和患者样品中的细胞凋亡,同时保留健康细胞。 了解更多

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