Epigenetic Reader Domain

Catalog No.Inhibitor Name Epigenetic Reader Domain
A12729(*)-JQ1
***
A11783I-BET151
*
A12545PFI-1
**
A11440I-BET-762
***
A13956RVX-208
*
A13227SGC-CBP30
****
A13163Bromosporine
****
A13890OTX015
****
A12948UNC1215
**
A13717UNC669
*
A14133GSK1324726A
***
A13749MS436
**
A13068CPI-203
***
A13957PFI-3

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

7 个项目

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  1. PF-CBP1

    Catalog No. A15876
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    CREBBP 抑制剂
    PF-CBP1是CREB结合蛋白(CREBBP)溴结构域的高度选择性抑制剂,它抑制CREBBP和p300溴结构域,IC50分别为125和363 nM。 了解更多
  2. C646

    Catalog No. A12815
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    p300/CBP 抑制剂
    C646是选择性的p300/CREB结合蛋白(CBP)抑制剂(Ki = 400 nM)。 了解更多
  3. EML 425

    Catalog No. A16180
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    CBP/p300 抑制剂
    EML 425是一种可逆且非竞争性的CBP/p300抑制剂,具有细胞渗透性(IC50值分别为1.1和2.9 uM)。 了解更多
  4. Anacardic Acid

    Catalog No. A14226
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    KAT5 (Tip60), p300/PCAF 抑制剂
    Anacardic Acid是p300和p300/CBP相关因子组蛋白乙酰转移酶的有效抑制剂。 了解更多
  5. CPI-637

    Catalog No. A16470
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    CBP/EP300 bromodomain 抑制剂
    CPI-637是一种选择性的,具有细胞活性的苯并二氮杂酮CBP/EP300溴结构域抑制剂。 了解更多
  6. I-CBP112

    Catalog No. A13165
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    CBP/p300 bromodomain 抑制剂
    I-CBP112是一种高效且选择性的p300/CBP溴结构域抑制剂(对于CBP,IC50为?0.14-0.17 uM,对于p300为?0.625 uM)。 了解更多
  7. SGC-CBP30

    Catalog No. A13227
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    CBP/p300 bromodomain 抑制剂
    SGC-CBP30是一种有效且选择性的CREBBP(CBP)和EP300抑制剂,无细胞试验中IC50分别为21 nM和38 nM。它们是一般的转录共激活因子。 了解更多

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