A-1331852

目录号: A16190

BCL-XL 抑制剂

A-1331852

A-1331852 Chemical Structure

CAS NO. 1430844-80-6

A-1331852是有效的选择性BCL-XL抑制剂。BCL-XL是主要的抗凋亡生存蛋白,可能是CML中的新型治疗靶标。

库存: 现货

规格 价格 数量
5 mg
¥ 840.00
10 mg
¥ 1,400.00
50 mg
¥ 4,690.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

A-1331852是有效的选择性BCL-XL抑制剂。BCL-XL是主要的抗凋亡生存蛋白,可能是CML中的新型治疗靶标。
靶点信息
Bcl-xL Bcl-w Bcl-2 Mcl-1
<0.01 nM(Ki)4 nM(Ki)6 nM(Ki)142 nM(Ki)
In vitro DMSO 91 mg/mL (138.12 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.18 mL 75.89 mL 151.79 mL
0.5 mM 3.04 mL 15.18 mL 30.36 mL
1 mM 1.52 mL 7.59 mL 15.18 mL
5 mM 0.3 mL 1.52 mL 3.04 mL

*The above data is based on the productmolecular weight 658.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A16190
作用机制 Inhibitor (抑制剂)
M. Wt 658.82
Formula C38H38N6O3S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1430844-80-6
Synonyms A 1331852, A1331852
SMILES CC1=C(C=NN1CC23CC4CC(C2)CC(C4)C3)C5=C(N=C(C=C5)N6CCC7=CC=CC(=C7C6)C(=O)NC8=NC9=CC=CC=C9S8)C(=O)O

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