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￥ 0.00 “MK-2206 dihydrochloride”的搜索结果
49 个项目
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Ipatasertib dihydrochloride
Catalog No. A21734 pan-Akt inhibitorIpatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. 了解更多 -
GDC-0575 dihydrochloride
Catalog No. A21567 CHK1 inhibitorGDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. 了解更多 -
GSK3368715 dihydrochloride
Catalog No. A21733 PRMT inhibitorGSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). 了解更多 -
LCL521 dihydrochloride
Catalog No. A21656 ACDase inhibitorLCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) is an acid ceramidase (ACDase) inhibitor. 了解更多 -
Lerociclib dihydrochloride
Catalog No. A21577 CDK4/CDK6 inhibitorLerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. 了解更多 -
NVP-BSK805 dihydrochloride
Catalog No. A21406 JAK2 inhibitorNVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively. 了解更多 -
Mirodenafil dihydrochloride
Catalog No. A18047 PDE-5 inhibitorMirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. 了解更多 -
Canertinib dihydrochloride
Catalog No. A11344 EGFR inhibitorCanertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. 了解更多 -
Azaphen dihydrochloride monohydrate
Catalog No. A15009 -
MW-150 dihydrochloride dihydrate
Catalog No. A21860 p38α MAPK inhibitorMW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. 了解更多 -
Liarozole dihydrochloride
Catalog No. A21853 CYP450 dependent inhibitorLiarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). 了解更多 -
LDK378 (Ceritinib) dihydrochloride
Catalog No. A15142 ALK 抑制剂LDK378 (Ceritinib) dihydrochloride是有效的抗ALK抑制剂，IC50为0.2 nM，对IGF-1R和InsR的选择性分别为40倍和35倍。 了解更多 -
Veliparib dihydrochloride
Catalog No. A21356 PARP inhibitorVeliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. 了解更多 -
GSK-LSD1 dihydrochloride
Catalog No. A21815 LSD1 inhibitorGSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM. 了解更多 -
K-604 dihydrochloride
Catalog No. A21773 ACAT-1 inhibitorK-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45??0.06 μM. 了解更多 -
MRT68921 dihydrochloride
Catalog No. A21650 ULK1/ULK2 inhibitorMRT68921 dihydrochloride is the most potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. 了解更多 -
PF429242 dihydrochloride
Catalog No. A21386 S1P inhibitorPF429242 dihydrochloride is a reversible and competitive S1P inhibitor with an IC50 of 175 nM. 了解更多 -
L-NIO dihydrochloride
Catalog No. A13027 NOS inhibitorL-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor. 了解更多 -
LY2801653 dihydrochloride
Catalog No. A15150 -
H-1152 dihydrochloride
Catalog No. A15102 ROCK 抑制剂H-1152 dihydrochloride是一种异喹啉磺酰胺衍生物，是Rho激酶的一种更特异，更强且可透过膜的抑制剂，Ki值为1.6 nM，但对其他丝氨酸/苏氨酸激酶的抑制作用较弱。 了解更多 -
3AC
Catalog No. A12817 -
B-Raf inhibitor 1 dihydrochloride
Catalog No. A21834 Raf kinase inhibitorB-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. 了解更多 -
DDR1-IN-1 dihydrochloride
Catalog No. A21813 DDR1 receptor tyrosine kinase inhibitorDDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM). 了解更多 -
Lexibulin dihydrochloride
Catalog No. A21774 tubulin polymerisation inhibitorLexibulin 2Hcl (CYT-997 2Hcl) is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. 了解更多 -
UAMC 00039 dihydrochloride
Catalog No. A16047 DPP-II 抑制剂UAMC 00039 dihydrochloride是二肽基肽酶II（DPP-II）的有效抑制剂（IC50 = 0.48 nM）。展示了DPP-II对DPP-9，DPP-8和DPP-IV的选择性（IC50值分别为78.6、142和165μM）。 了解更多 -
ML 786 dihydrochloride
Catalog No. A11211 Raf 抑制剂ML 786 dihydrochloride是一种有效的Raf激酶抑制剂（B-RafV600E，C-Raf和野生型B-Raf的IC50值分别为2.1、2.5和4.2 nM）。 了解更多 -
SKF 86002 Dihydrochloride
Catalog No. A11101 p38 MAPK 抑制剂SKF 86002 Dihydrochloride是p38 MAP激酶的抑制剂（IC50 = 0.1-1 uM）。有效抑制人单核细胞中LPS诱导的IL-1和TNF-α的产生（IC50 = 1 uM）。 了解更多 -
AT7867 2HCl
Catalog No. A15006 Akt 抑制剂AT7867 dihydrochloride是一种有效的ATP竞争性Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 nM/47 nM和85 nM/20 nM，在AGC激酶家族之外几乎没有活性。 了解更多 -
HA-1077 dihydrochloride
Catalog No. A13785 -
1400W Dihydrochloride
Catalog No. A13583 INOS 抑制剂1400W Dihydrochloride是一种缓慢，紧密结合，有效和高度选择性的诱导型一氧化氮合酶抑制剂（Kd = 7 nM）。对nNOS和eNOS具有选择性（Ki值分别为2和50μM）。细胞可渗透并在体内具有活性。 了解更多 -
SR 3677 dihydrochloride
Catalog No. A12674 ROCK 抑制剂SR 3677 dihydrochloride是一种有效的选择性Rho激酶抑制剂（ROCK-II和ROCK-I的IC50值分别为3和56 nM）。 了解更多 -
Y-33075 dihydrochloride
Catalog No. A11611 ROCK inhibitorY-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM. 了解更多 -
Minaprine dihydrochloride
Catalog No. A17722 MAO-A inhibitorMinaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression. 了解更多 -
DBM 1285 dihydrochloride
Catalog No. A16058 -
GGACK Dihydrochloride
Catalog No. A16057 Urokinase 抑制剂GGACK Dihydrochloride是尿激酶（uPA（ICkin <1 ?M），凝血因子VIIa，凝血因子IXa，凝血因子Xa和胰蛋白酶的有效且不可逆的抑制剂。 了解更多 -
Alexidine dihydrochloride
Catalog No. A15382 -
BAY 61-3606 dihydrochloride
Catalog No. A15017 -
GBR 12783 dihydrochloride
Catalog No. A13128 dopamine uptake 抑制剂GBR 12783 dihydrochloride是一种非常有效的选择性多巴胺摄取抑制剂（抑制大鼠纹状体突触体中[3H]-多巴胺摄取的IC50为1.8 nM）。 了解更多 -
Vanoxerine 2HCl (GBR-12909)
Catalog No. A10725 dopamine re-uptake 抑制剂Vanoxerine 2HCl (GBR-12909)是哌嗪衍生物，是一种有效的、选择性的多巴胺摄取（dopamine uptake）抑制剂。 了解更多 -
KX2-391 2HCl
Catalog No. A11471 Src 抑制剂Tirbanibulin dihydrochloride是首个靶向Src肽底物位点的临床Src抑制剂(拟肽类),在癌细胞系中GI50为9-60 nM。 了解更多 -
NVP DPP 728 dihydrochloride
Catalog No. A15320 DPP-4 抑制剂NVP DPP 728 dihydrochloride是一种有效的活性二肽基肽酶(DPP)-IV抑制剂，Ki和IC50值分别为11 nM和14 nM。 了解更多 -
Nolatrexed Dihydrochloride
Catalog No. A13261 -
GBR-12935 2HCl
Catalog No. A11937 -
Anlotinib HCl
Catalog No. A17076 -
HA-100 (C1)
Catalog No. A17019 PKs 抑制剂HA-100 dihydrochloride是具有添加的哌嗪基磺酰基的异喹啉化合物，可充当蛋白激酶（PKs）的抑制剂，包括PKA，PKC和PKG（IC50分别为8、12和4 μM）。 了解更多 -
Sardomozide HCl
Catalog No. A15987 polyamine synthesis 抑制剂Sardomozide dihydrochloride是第二代多胺合成抑制剂，可抑制多胺生物合成酶S-腺苷甲硫氨酸脱羧酶（SAMDC）的活性。 了解更多 -
K-7174 2HCl
Catalog No. A15446 Cell adhesion 抑制剂K-7174 dihydrochloride是一种新型的细胞粘附抑制剂；抑制由IL-1beta或TNF-alpha诱导的血管细胞粘附分子1（VCAM-1）的表达。 了解更多
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- Epigenetics (3)
- PI3K / Akt / mTOR (3)
- Protein Tyrosine Kinases (4)
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- JAK / Stat (2)
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- DNA Damage (2)
- Cell Metabolism (3)
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