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搜索结果：“jwh 250”

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(-)-Epigallocatechin gallate

Catalog No. A10005
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Antioxidant, antiangiogenic, antitumor agent

(-)-Epigallocatechin gallate是一种从绿茶中分离出来的强效抗氧化剂多酚类黄酮。了解更多

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- Wafa Dridi, .et al. Influence of polysaccharide concentration on polyphenol-polysaccharide interactions, Carbohydr Polym, 2021, 274:118670 PMID: 34702486
- A S D'Costa, .et al. Inhibition of starch digestion by flavonoids: Role of flavonoid-amylase binding kinetics, Food Chem, 2020, Oct 1;341(Pt 2):128256 PMID: 33035827
- Fenteany G, .et al. Multilevel structure-activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism, Sci Rep, 2019, Sep 5;9(1):12801 PMID: 31488855
- LiliSun, .et al. Comparative Effect of Black, Green, Oolong and White Tea Intake on Body Weight Gain and Bile Acid Metabolism, Nutrition, 2019, pii:S0899-9007(18)31140-7
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Gefitinib (Iressa)

Catalog No. A10422
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EGFR 抑制剂

Gefitinib (Iressa)是一种EGFR抑制剂，可阻断靶细胞中表皮生长因子受体(EGFR)的信号传导。了解更多

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- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Mansi Srivastava, .et al. Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses, Int Immunopharmacol, 2019, 71: 188-197 PMID: 30909134
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Chrysophanic acid (Chrysophanol)

Catalog No. A10210
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EGFR 抑制剂

Chrysophanic acid (Chrysophanol)是通过抑制EGFR/mTOR通路来阻止结肠癌细胞的增殖。了解更多

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Tyrphostin AG 879

Catalog No. A10053
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HER2 抑制剂

Tyrphostin AG 879是神经生长因子（NGF）TrkA酪氨酸激酶活性的抑制剂。了解更多

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AZD8931 (Sapitinib)

Catalog No. A10116
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pan-EGFR/pan-erbB 抑制剂

AZD8931 (Sapitinib)是ErbB1，ErbB2和ErbB3受体信号传导的等效抑制剂。了解更多

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- Takeshi Ito, .et al. Mathematical analysis of gefitinib resistance of lung adenocarcinoma caused by MET amplification, Biochem Biophys Res Commun, 2019, in Press
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AG-1478 (Tyrphostin AG-1478)

Catalog No. A11022
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EGFR 抑制剂

AG-1478 (Tyrphostin AG-1478)是EGFR激酶的抑制剂，IC50值为3 nM。了解更多

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- Khattab M, .et al. Conformational Plasticity in Tyrosine Kinase Inhibitor-Kinase Interactions Revealed with Fluorescence Spectroscopy and Theoretical Calculations, J Phys Chem B, 2018, May 3;122(17):4667-4679 PMID: 29629773
- Muhammad Khattab, .et al. A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations, Sci Rep, 2017, 7: 16271 PMID: 29176733
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XL647 (Tesevatinib)

Catalog No. A11057
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EGFR, HER2 and VEGFR 抑制剂

XL647 (Tesevatinib)是一种口服生物可利用的小分子RTK抑制剂，可结合并抑制在肿瘤细胞增殖和肿瘤血管形成中起主要作用的几种酪氨酸受体激酶，包括EGFR，HER2，ERBB2，VEGFR和EphB4。了解更多

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BMS-690514

Catalog No. A11263
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VEGFR/EGFR 抑制剂

BMS-690514是一种有效的选择性表皮生长因子受体（EGFR），HER2和HER4抑制剂，以及VEGF受体激酶。了解更多

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ASP8273 (Naquotinib)

Catalog No. A14408
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irreversible EGFR 抑制剂

ASP8273 (Naquotinib)是不可逆的，第三代，选择性突变的表皮生长因子受体（EGFR）抑制剂，具有潜在的抗肿瘤活性。了解更多

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EGF816 (Nazartinib)

Catalog No. A14416
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EGFR T790M 抑制剂

EGF816 (Nazartinib)是新型的突变选择性EGFR共价抑制剂。克服了NSCLC中T790M介导的耐药性。了解更多

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CL-387785 (EKI-785)

Catalog No. A13146
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EGFR 抑制剂

CL-387785是EGFR的不可逆抑制剂，IC50为370+/-120 pM；能够在功能水平上克服由T790M突变引起的抗药性。了解更多

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PD168393

Catalog No. A12725
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EGFR 抑制剂

PD168393是一种有效的，细胞可渗透的，不可逆的EGFR抑制剂，IC50值为700 pM。了解更多

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Nazartinib mesylate

Catalog No. A21741
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covalent mutant-selective EGFR inhibitor

Nazartinib mesylate (EGF816 mesylate) is a novel, covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min?1 on EGFR(L858R/790M) mutant, respectively. 了解更多

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