“betaine hydrochloride”的搜索结果
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5-HT Receptor 激动剂
Clomipramine HCl是下列转运蛋白的阻滞剂:5-羟色胺转运蛋白 (SERT)(Ki = 0.14 nM),去甲肾上腺素转运蛋白(NET)(Ki = 54 nM),多巴胺转运蛋白(DAT)(Ki = 3,020 nM),甘氨酸转运蛋白(GlyT/LeuT)。
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adrenergic receptor/5-HT receptor 抑制剂
Asenapine hydrochloride抑制肾上腺素能受体(α1,α2A,α2B,α2C)的Ki为0.25-1.2 nM,还抑制5-HT受体(1A,1B,2A,2B,2C,5A,6、7),Ki为0.03- 4.0 nM。
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5-HT3 receptor 拮抗剂
Azasetron HCl是一种选择性的5-HT3受体拮抗剂,IC50为0.33 nM,用于治疗癌症化学疗法引起的恶心和呕吐。
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5-HT2 receptors inhibitor
Nefazodone HCl is an inhibitor of 5-HT2 receptors, SERT, NET, and hERG K+ channels used to treat mood disorders. It decreases immobility time in the forced swim test.
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Urapidil hydrochloride是α1肾上腺素受体拮抗剂、5-HT1A血清素受体部分激动剂和抗高血压药。
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5HT3-receptor 拮抗剂
Alosetron Hydrochloride是一种5-羟色胺5HT3受体拮抗剂,可用于治疗肠易激综合症。
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serotonin/histamine2 拮抗剂
Cyproheptadine hydrochloride是抗组胺药,是5-羟色胺和组胺的拮抗剂。
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norepinephrine (NE) transporter 抑制剂
Atomoxetine HCl是SLC6A2的一种竞争性特异性抑制剂,同时在大鼠下丘脑突触体中显示出微弱的ST和DAT抑制作用。
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Trazodone HCl 是一种抗抑郁药,属于5-羟色胺受体拮抗剂和再摄取抑制剂。
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5-HT1D receptor 拮抗剂
BRL-15572是一种选择性的h5-HT1D拮抗剂,相对于h5-HT1B表现出60倍的选择性,对一系列其他受体类型的亲和力很小或没有亲和力。
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5-HT1A and α1-adrenergic receptor 拮抗剂
Naftopidil 2HCl是选择性5-HT1A和α1-肾上腺素能受体拮抗剂,IC50分别为0.1μM和0.2μM。
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Duloxetine Hydrochloride是一种5-羟色胺和去甲肾上腺素再摄取抑制剂(SNRI),Ki为 4.6 nM。用于治疗压力性尿失禁和抑郁症。
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5-HT6 拮抗剂
SB 399885 hydrochloride是一种有效的,脑渗透剂和口服活性的SR-6拮抗剂。它对SR-6的选择性比其他血清素受体高200倍(对于人类重组,天然大鼠和天然人类SR-6受体,pKi值分别为9.11、8.81和9.02)。
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5-HT6 serotonin receptor 拮抗剂
SB 258585 hydrochloride是一种选择性和有效的SR-6拮抗剂。该化合物显示出比其他5-羟色胺受体亚型高160倍的选择性。
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5HT(1A) receptor 激动剂
Buspirone hydrochloride是一种具有5-D(2)多巴胺能作用的血清素能(5HT(1A)受体激动剂)抗焦虑药,用于焦虑症。
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5-HT1A receptor agonist
Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes.
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5-HT3 receptor 拮抗剂
Granisetron Hydrochloride是血清素5-ht3受体拮抗剂。
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SNR 抑制剂
Sibutramine hydrochloride是5-HT和去甲肾上腺素再摄取抑制剂(SNRI)。
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5-HT1F 激动剂
LY 334370 hydrochloride是一种选择性的5-HT1F受体激动剂(Ki值为1.87、16.4,> 100 (IC50))。CAS:199673-74-0(LY 334370盐酸盐);182563-08-2(LY 334370游离碱)
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5-HT1F agonist
LY 344864 hydrochloride is a selective 5-HT1F agonist with a Ki of 6 nM.
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5-HT2/5-HT1 拮抗剂
Mianserin hydrochloride是5-HT2/5-HT1拮抗剂。对5-HT6非选择性5-HT2受体拮抗剂具有中等亲和力。对5-HT6具有中等亲和力。
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serotonin 2C receptor 激动剂
lorcaserin hydrochloride (APD-356)是血清素2C受体激动剂,可指示与减少热量饮食和增加体育锻炼以减轻慢性体重成人管理。
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- Li Li, .et al. Delineating a serotonin 1B receptor circuit for appetite suppression in mice, J Exp Med, 2022, Aug 1;219(8):e20212307 PMID: 35796804
- Henrik H. Hansen, .et al. Whole-brain activation signatures of weight-lowering drugs, Mol Metab, 2021, May;47:101171 PMID: 33529728
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5-HT1A receptor 拮抗剂
NAD 299 hydrochloride (Robalzotan)是一种选择性的,高亲和力的5-HT1A受体拮抗剂(体外Ki = 0.6 nM)。
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5-HT1A receptor antagonist
Alprenolol (hydrochloride) is a non-selective beta blocker as well as 5-HT1A receptor antagonist.
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5-HT6 receptor antagonist
SB271046 Hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.
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5-HT (serotonin)/dopamine receptor antagonist
Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
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5-HT2 antagonist
Sarpogrelate hydrochloride (MCI-9042), a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.
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5-HT2C receptor antagonist
SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.
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5-HT1B receptor antagonist
SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.
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Dapoxetine hydrochloride是通过抑制5-羟色胺转运蛋白,增加5-羟色胺在突触后裂隙中的作用并因此促进射精延迟而起作用。
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5-HT7 receptor antagonist
SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors.
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5-HT2c receptor agonist
PRX933 hydrochloride is a 5-HT2c receptor agonist extracted from patent WO 2014140631 A1.
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5-HT (serotonin) and dopamine receptor antagonist
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
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Serotonin 5HT3-receptor antagonist
Alosetron Hydrochloride(1:X) (GR 68755 Hydrochloride(1:X)) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
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