“angiotensin converting enzyme ace”的搜索结果
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BACE1 抑制剂
LY2886721是一种有效的,选择性的,口服活性的β位淀粉样蛋白前体蛋白裂解酶 1 (BACE1) 抑制剂。LY2886721是一种新型强效药物,用于治疗阿尔茨海默病的研究。
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- Naomi Ito, .et al. miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation, Br J Pharmacol, 2017, Mar; 174(5): 386-395 PMID: 28012171
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Gamma-secretase 抑制剂
BMS-708163 (Avagacestat)是口服生物有效的,选择性的γ-分泌酶抑制剂,作用于Aβ40和Aβ42时,IC50分别为0.3 nM和0.27 nM。
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Gamma-secretase 抑制剂
Semagacestat (LY450139)是一种针对Aβ42,Aβ40和Aβ38的γ-分泌酶阻滞剂,IC50分别为10.9 nM,12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导,IC50为14.1 nM。
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- Yesuvadian R, .et al. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study., Biochem Biophys Res Commun., 2014, May 16;447(4):590-5 PMID: 24747079
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BACE1 抑制剂
LY2811376是第一种可口服的非肽类BACE1抑制剂,可在动物体内产生显着的Aβ降低作用。
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BACE1 抑制剂
AZD3839是人类BACE1的有效选择性抑制剂,Ki为26.1 nM。
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BACE1 抑制剂
AMG-8718是一种有效的BACE1抑制剂。
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BACE1 抑制剂
Timosaponin B-II是知母草(Liliaceae,根茎)的主要活性成分,对脑缺血性损伤具有保护作用。
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γ-secretase 抑制剂
Begacestat (GSI-953)是一种新型的选择性淀粉样前体蛋白γ-分泌酶的噻吩磺酰胺抑制剂。
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β-secretase/BACE1 抑制剂
Verubecestat (MK-8931)是一种有效的选择性β-分泌酶抑制剂,是BACE1蛋白抑制剂或Beta-site APP裂解酶1抑制剂。
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BACE1 inhibitor
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer??s disease.
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BACE1 inhibitor
Lanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM.
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BACE1 inhibitor
BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
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BACE-1 inhibitor
β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
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BACE1 inhibitor
PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.
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BACE-1 inhibitor
Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively.
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BACE1 inhibitor
AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.
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