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￥ 0.00 “kinase inhibit”的搜索结果
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Dorzagliatin
Catalog No. A22297 GK activatorDorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes. 了解更多 -
Lavendustin B
Catalog No. A22298 GLUT1 inhibitorLavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 ?M. Lavendustin B is also a weak inhibitor of tyrosine kinases. 了解更多 -
Ribociclib hydrochloride
Catalog No. A22303 CDK4/6 inhibitorRibociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, 了解更多 -
BDTX-189
Catalog No. A22306 Anticancer agentBDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity. 了解更多 -
LDN-193189 2HCl
Catalog No. A22307 BMP signaling inhibitorLDN193189 HCl (DM-3189) is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cell lines, respectively, 200-fold selectivity for BMP versus TGF-β. 了解更多 -
BpV(HOpic)
Catalog No. A22308 PTEN inhibitorBpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity. 了解更多 -
Ferulic acid sodium
Catalog No. A22310 FGFR1 inhibitorFerulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively. 了解更多 -
Alflutinib
Catalog No. A22316 EGFR inhibitorAlflutinib is an EGFR inhibitor that targets both EGFR activating mutations and T790M, thus leading to tumor growth inhibition. 了解更多 -
Benzamidine hydrochloride
Catalog No. A22323 trypsin-like serine proteases inhibitorBenzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 ?M, 21 ?M, 20 ?M and 110 ?M for uPA, trypsin, tryptase and factor Xa, respectively. 了解更多 -
Mobocertinib
Catalog No. A22334 inhibitor of EGFR and HER2 oncogenic mutantsMobocertinib (TAK-788) is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity. 了解更多 -
3'-Hydroxypterostilbene
Catalog No. A22341 natural pterostilbene analogue3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 了解更多 -
7-Nitroindazole
Catalog No. A22342 neuronal nitric oxide synthase inhibitor7-Nitroindazole, a heterocyclic compound, acts as a selective inhibitor for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS. 了解更多 -
JNJ-38158471
Catalog No. A22345 VEGFR-2 inhibitorJNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively. 了解更多 -
3-Deazaadenosine hydrochloride
Catalog No. A22347 inhibitor of S-adenosylhomocysteine hydrolase3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 ?M; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity. 了解更多 -
CCG-222740
Catalog No. A22348 MRTF pathway inhibitorCCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. 了解更多 -
Timosaponin AIII
Catalog No. A22353 Inhibitor of U46619-induced Rat Platelet AggregationTimosaponin AIII is a potent Inhibitor of U46619-induced Rat Platelet Aggregation, Selectively Inhibiting TxA2-induced Platelet Activation, Preferably Suppressing TP-mediated Activation of Gq, not G12/13, Signaling Pathways. 了解更多 -
Solamargine
Catalog No. A22357 anticancer agentSolamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. 了解更多 -
TG-89
Catalog No. A22361 -
SEL24-B489 HCl
Catalog No. A22203 -
Durlobactam sodium
Catalog No. A13801 beta-lactamase inhibitor drug candidateDurlobactam, also known as ETX2514, is a beta-lactamase inhibitor drug candidate. 了解更多 -
Etanercept
Catalog No. A12009 TNF inhibitorEtanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. 了解更多 -
IACS-13909
Catalog No. A22159 SHP2 allosteric inhibitorIACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. 了解更多 -
ATR inhibitor 2
Catalog No. A22162 ATR inhibitorATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. 了解更多 -
Laninamivir octanoate
Catalog No. A22166 neuraminidase (NA) inhibitorLaninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. 了解更多 -
Conoidin A
Catalog No. A22167 cell permeable inhibitorConoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII). 了解更多 -
Eurycomanone
Catalog No. A22171 Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. 了解更多 -
Gentiopicroside
Catalog No. A22172 antianti-inflammatoryand antioxidative effectsGentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 ?M and 22.8 ?M for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects. 了解更多 -
Groenlandicine
Catalog No. A22176 protoberberine alkaloidGroenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR). 了解更多 -
6-Methoxydihydroavicine
Catalog No. A22177 antiplatelet activities6-Methoxydihydroavicine is an alkaloid isolated from Zanthoxylum integrifoliolum. 6-Methoxydihydroavicine has antiplatelet activities and inhibits AA-, collagen- and PAF-induced platelet aggregation in vitro. 了解更多 -
NSC23005 free acid
Catalog No. A22180 p18INK inhibitorNSC23005 is a p18INK inhibitor. NSC23005 potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). 了解更多 -
OTSSP167 hydrochloride
Catalog No. A22184 MELK inhibitorOTSSP167 (hydrochloride) is a highly potent MELK inhibitor with IC50 value of 0.41 nM. 了解更多
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