FAK

Catalog No.Inhibitor Name FAKOther
A12580PF-00562271
****
CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11192PF-562271
****
CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11235PF-573228
*
A11507TAE226
**
Insulin Receptor,IGF-1R,c-Met
A11171PF-03814735
*
Aurora A,Aurora B,FLT1
A11142PF-431396
**
A13140PND-1186
****
A11929Defactinib
A15543CEP-37440
**
ALK
A15765GSK2256098
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. NVP-TAE 226

    Catalog No. A11507
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    FAK 抑制剂
    NVP-TAE 226是一种强效FAK抑制剂,IC50为5.5 nM,对pyk2(IC50=3.5 nM)有适度的强效作用;对InsR, IGF-1R, ALK和c-Met的效力降低10-100倍。 了解更多
  2. PF-4618433

    Catalog No. A13461
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    PYK2/FAK 抑制剂
    PF-4618433与原型BIRB796相比,PF-4618433显示出PYK2效价提高、p38活性降低和总体选择性优越。 了解更多
  3. PF 431396

    Catalog No. A11142
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    FAK/PYK2 抑制剂
    PF 431396是一种双粘着斑激酶(FAK)和富含脯氨酸的酪氨酸激酶2(PYK2)抑制剂(IC50值分别为2和11 nM)。 了解更多
  4. PF-00562271

    Catalog No. A12580
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    FAK 抑制剂
    PF-00562271是PF-562271的苯磺酸盐,是一种有效的,ATP竞争性,可逆的FAK和Pyk2抑制剂,IC50分别为1.5 nM和14 nM。 了解更多

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