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Microbiology

Microbiology

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BMS-663068 Tris

Catalog No. A15026
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HIV-1 attachment 抑制剂

BMS-663068 tris是HIV-1附着抑制剂，可用于治疗HIV-1感染。了解更多

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Fosamprenavir Calcium Salt

Catalog No. A15089
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HIV protease 抑制剂

Fosamprenavir Calcium Salt 是抗逆转录病毒蛋白酶抑制剂amprenavir的磷酸酯前药，与母体分子相比具有更高的溶解度，并有可能减轻当前给药方案中的药丸负担；GW433908G是前药的钙盐。了解更多

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Tipranavir

Catalog No. A15262
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HIV protease 抑制剂

Tipranavir是一种非肽类HIV蛋白酶抑制剂（NPPI），可抑制HIV-1蛋白酶的酶促活性和二聚作用，对多种抗PI的HIV-1分离株具有有效的活性。了解更多

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Enfuvirtide Acetate(T-20)

Catalog No. A15825
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HIV fusion 抑制剂

Enfuvirtide Acetate (T-20)是一个36个氨基酸的肽段，对应于gp41（HIV-1包膜蛋白的跨膜亚基）区域。了解更多

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Trovirdine

Catalog No. A13199
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HIV-1 RT 抑制剂

Trovirdine当使用杂聚合引物/模板（寡DNA/核糖体RNA）和dGTP作为底物时，trovirdine抑制HIV-1 RT的IC50为7 nM。了解更多

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Nelfinavir

Catalog No. A11504
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HIV-1 protease 抑制剂

Nelfinavir是一种有效的口服生物可利用的人类免疫缺陷病毒HIV-1蛋白酶抑制剂(Ki=2 nM ),广泛用于与HIV逆转录酶抑制剂联合治疗HIV感染。了解更多

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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
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(±)-BI-D

Catalog No. A16024
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Allosteric IN 抑制剂

(±)-BI-D 是有效的ALLINI（一种变构IN抑制剂），在LEDGF/p75结合位点结合整合酶。了解更多

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GSK2838232

Catalog No. A15965
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HIV maturation 抑制剂

GSK2838232是一种新型的人类免疫病毒（HIV）成熟抑制剂，正在开发用于治疗慢性HIV感染。了解更多

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Darunavir

Catalog No. A20829
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HIV protease inhibitor

Darunavir is an HIV protease inhibitor 了解更多

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Cenicriviroc

Catalog No. A13643
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CCR2/CCR5 抑制剂

Cenicriviroc是用于治疗HIV感染的实验性候选药物.Cenicriviroc是CCR2和CCR5受体的抑制剂，可使其充当阻止病毒进入人体细胞的进入抑制剂。了解更多

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Aplaviroc

Catalog No. A13471
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CCR5 entry 抑制剂

Aplaviroc是一种CCR5进入抑制剂，用于治疗HIV感染。了解更多

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Cenicriviroc Mesylate

Catalog No. A17028
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CCR2/5 receptors 抑制剂

Cenicriviroc(TAK-652,TBR-652)是CCR2和CCR5受体的抑制剂，可使其充当防止病毒进入人细胞的进入抑制剂了解更多

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ML604086

Catalog No. A18969
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CCR8 抑制剂

ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations. 了解更多

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Retapamulin (SB-275833)

Catalog No. A11139
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Antibacterial agent

Retapamulin (SB-275833)是一种抗菌剂，特别是蛋白质合成抑制剂。了解更多

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- Merianne Mohamad, .et al. Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci, Nucleic Acids Res, 2022, Feb 28;50(4):2128-2142 PMID: 35137182
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Peramivir

Catalog No. A11124
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Neuraminidase 抑制剂

Peramivir是一种神经氨酸酶抑制剂，可作为流感神经氨酸酶的过渡态类似物抑制剂，从而防止新病毒从受感染的细胞中出现。了解更多

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- Daisuke Kato, .et al. An easy, rapid, and sensitive method for detection of drug-resistant influenza virus by using a sialidase fluorescent imaging probe, BTP3-Neu5Ac, PLoS One, 2018, 13(7): e0200761 PMID: 30001430
- Yuuki Kurebayashi, .et al. High-Efficiency Capture of Drug Resistant-Influenza Virus by Live Imaging of Sialidase Activity, PLoS One, 2016, 11(5): e0156400 PMID: 27232333
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Linezolid (PNU-100766)

Catalog No. A10533
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Protein synthesis 抑制剂

Linezolid是一种用于治疗严重感染的合成抗生素。了解更多

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- Viktoria Lazar, .et al. Antibiotic combinations reduce Staphylococcus aureus clearance, Nature, 2022, 610: 540-546 PMID: 36198788
- Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
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TMC353121

Catalog No. A11585
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RSV fusion 抑制剂

TMC353121是一种有效的体外RSV融合抑制剂，pEC50 为 9.9。抗病毒药，也是治疗RSV疾病的新型候选药物。了解更多

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Micafungin Sodium

Catalog No. A14246
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1,3-beta-D-glucan synthesis 抑制剂

Micafungin Sodium是1，3-β-D-葡聚糖合成的抑制剂。了解更多

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Laninamivir (CS-8958)

Catalog No. A12998
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Neuraminidase 抑制剂

Laninamivir (CS-8958)是一种神经氨酸酶抑制剂，正在研究用于治疗和预防A型流感病毒和B型流感病毒。其对流感病毒 H12N5 NA (N5)，pH1N1 N1 NA (p09N1) 和 A/RI/5+/1957 H2N2 N2 (p57N2) 的 IC50 分别为 0.90 nM、1.83 nM 和 3.12 nM。了解更多

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Ascomycin (FK520)

Catalog No. A15788
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Calcineurin/PP2B 抑制剂

Ascomycin (FK520)是他克莫司的乙基类似物（FK506），具有强的免疫抑制特性。已经研究出其用于治疗自身免疫疾病和皮肤疾病，并防止器官移植后的排斥反应。了解更多

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Fiacitabine

Catalog No. A11422
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HSV DNA replication 抑制剂

Fiacitabine是单纯疱疹病毒(HSV)DNA复制的选择性抑制剂，HSV1和HSV2的IC50值分别为2.5 nM和12.6 nM。了解更多

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Presatovir (GS-5806)

Catalog No. A15835
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Antiviral fusion 抑制剂

Presatovir (GS-5806)是一种新型的，生物利用的RSV融合抑制剂，可抗多种RSV A和B临床分离株（平均EC50 = 0.43 nM）。了解更多

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Aminothiazole

Catalog No. A16403
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Thyroid 抑制剂

Aminothiazole可用作甲状腺抑制剂，并具有抗菌活性。了解更多

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Morphothiadin

Catalog No. A17020
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HBV 抑制剂

1793065-08-3（R-异构体）2093044-32-5（S-异构体）1092970-12-1（外消旋）1646361-04-7（甲磺酸酯）了解更多

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Bay 41-4109 less active enantiomer

Catalog No. A21681
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HBV inhibitor

Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. 了解更多

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RG7834

Catalog No. A21816
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HBV inhibitor

RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells. 了解更多

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Entecavir

Catalog No. A17569
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HBV inhibitor

Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell. 了解更多

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