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Proteases

产品 101 到 150 共 292个

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  1. Ledipasvir acetone
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    Ledipasvir acetone

    Catalog No. A18055
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    HCV NS5A inhibitor
    Ledipasvir acetone is the active pharmaceutical ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. 了解更多
  2. Voxilaprevir
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    Voxilaprevir

    Catalog No. A12067
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    HCV NS 3/4A protease inhibitor
    Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs). 了解更多
  3. PSI-7409
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    PSI-7409

    Catalog No. A13962
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    nucleotide analog HCV inhibitor
    PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. 了解更多
  4. Mericitabine
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    Mericitabine

    Catalog No. A11539
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    HCV NS5B polymerase inhibitor
    Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication. 了解更多
  5. R-1479
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    R-1479

    Catalog No. A11540
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    HCV replication inhibitor
    R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM). 了解更多
  6. PSI-352938
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    PSI-352938

    Catalog No. A21253
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    HCV nucleotide inhibitor
    PSI-352938 (PSI-938) is a hepatitis C virus (HCV) nucleotide inhibitor. 了解更多
  7. Beclabuvir
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    Beclabuvir

    Catalog No. A21511
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    HCV NS5B RNA-dependent RNA polymerase inhibitor
    Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM. 了解更多
  8. PSI-7976
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    PSI-7976

    Catalog No. A21631
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    HCV RNA replication inhibitor
    PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. 了解更多
  9. Sofosbuvir impurity C
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    Sofosbuvir impurity C

    Catalog No. A21636
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    HCV RNA replication inhibitor
    Sofosbuvir impurity C is the less active impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. 了解更多
  10. Sofosbuvir impurity A
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    Sofosbuvir impurity A

    Catalog No. A21641
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    HCV RNA replication inhibitor
    Sofosbuvir impurity A, an diastereoisomer of sofosbuvir, is the impurity of sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity. 了解更多
  11. NM107
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    NM107

    Catalog No. A21761
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    HCV NS5B polymerase
    NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, the EC50 of NM107 in the wild-type replicon cells is 1.85 μM. 了解更多
  12. PSI-6206 13CD3
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    PSI-6206 13CD3

    Catalog No. A21782
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    HCV NS5B polymerase inhibitor
    PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. 了解更多
  13. HCV-IN-3
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    HCV-IN-3

    Catalog No. A20957
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    HCV NS3/4a protein inhibitor
    HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor, with an IC50 of 20 μM, a Kd of 29 μM. 了解更多
  14. BMS-790052 (Daclatasvir)
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    BMS-790052 (Daclatasvir)

    Catalog No. A10159
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    HCV NS5A 抑制剂
    BMS-790052 (Daclatasvir)是一种高度选择性的HCV NS5A抑制剂，EC50为9-50 pM，用于治疗丙型肝炎病毒（HCV）感染。 了解更多
  15. Danoprevir (RG7227)
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    Danoprevir (RG7227)

    Catalog No. A10284
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    HCV NS3/4A protease 抑制剂
    Danoprevir (RG7227)是HCV NS3/4A丝氨酸蛋白酶的有效抑制剂。 了解更多
  16. VX-222
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    VX-222

    Catalog No. A10980
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    HCV Protease 抑制剂
    VX-222是HCV NS5B聚合酶的小分子非核苷抑制剂，正在研究中，用于治疗丙型肝炎病毒感染。 了解更多
  17. Telaprevir (VX-950)
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    Telaprevir (VX-950)

    Catalog No. A10902
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    HCV NS3-4A protease 抑制剂
    Telaprevir (VX-950)被称为蛋白酶抑制剂，可抑制丙型肝炎病毒NS3.4A丝氨酸蛋白酶。 了解更多
  18. Anguizole
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    Anguizole

    Catalog No. A11294
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    HCV replication 抑制剂
    Anguizole是一种抑制HCV复制并改变NS4B亚细胞分布的小分子。 了解更多
  19. Asunaprevir (BMS-650032)
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    Asunaprevir (BMS-650032)

    Catalog No. A11295
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    NS3 protease 抑制剂
    Asunaprevir是病毒酶丝氨酸蛋白酶NS3的抑制剂。 了解更多
  20. Boceprevir (SCH-503034)
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    Boceprevir (SCH-503034)

    Catalog No. A11332
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    HCV Protease 抑制剂
    Boceprevir (SCH-503034)是一种蛋白酶抑制剂，可用于治疗C型肝炎基因型1。 了解更多
  21. Balapiravir (R1626)
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    Balapiravir (R1626)

    Catalog No. A11335
    Polymerase 抑制剂
    Balapiravir (R1626)是丙型肝炎病毒(HCV) RNA依赖性rna聚合酶(R1479，RG1479)核苷类似物抑制剂的前药。 了解更多
  22. BMS-790052 2HCl
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    BMS-790052 2HCl

    Catalog No. A11336
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    NS5A 抑制剂
    BMS-790052 2HCl是一种NS5A抑制剂，用于治疗丙型肝炎病毒(HCV)感染。 了解更多
  23. Ciluprevir (BILN 2061)
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    Ciluprevir (BILN 2061)

    Catalog No. A11343
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    HCV NS3 protease 抑制剂
    Ciluprevir (BILN 2061)是HCV NS3蛋白酶的一种特定而有效的拟肽抑制剂。 了解更多
  24. PSI-6130
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    PSI-6130

    Catalog No. A11519
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    HCV Nucleoside 抑制剂
    PSI-6130是丙型肝炎病毒核苷抑制剂。 了解更多
  25. Tegobuvir (GS-9190)
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    Tegobuvir (GS-9190)

    Catalog No. A11583
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    NS5B polymerase 抑制剂
    Tegobuvir (GS-9190)是一种非核苷NS5B聚合酶抑制剂。 了解更多
  26. VCH-916
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    VCH-916

    Catalog No. A12374
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    HCV NS5B polymerase 抑制剂
    VCH-916是一种新型非核苷HCV NS5B聚合酶抑制剂。 了解更多
  27. Setrobuvir (ANA-598)
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    Setrobuvir (ANA-598)

    Catalog No. A13105
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    HCV Polymerase 抑制剂
    Setrobuvir (ANA-598)是一种直接作用的抗病毒药物或DAA，是HCV RNA聚合酶的一种非核苷抑制剂。 了解更多
  28. Celgosivir
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    Celgosivir

    Catalog No. A13118
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    alpha-glucosidase I 抑制剂
    Celgosivir是一种用于潜在治疗HCV感染的α-葡萄糖苷酶I抑制剂。 了解更多
  29. Ledipasvir (GS 5885)
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    Ledipasvir (GS 5885)

    Catalog No. A13155
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    NS5A 抑制剂
    Ledipasvir (GS 5885)是丙型肝炎病毒HCV NS5A蛋白的抑制剂。 了解更多
  30. PSI-7977
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    PSI-7977

    Catalog No. A11529
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    HCV Nucleotide 抑制剂
    PSI-7977是PSI-7851的氨基磷酸酯前药，PSI-7851是核苷类似物，当磷酸化时，抑制丙型肝炎病毒的RNA依赖性RNA聚合酶(EC50 = 92 nM)。 了解更多
  31. PSI-6206
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    PSI-6206

    Catalog No. A11530
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    HCV RNA polymerase 抑制剂
    PSI-6206是PSI-6130的脱氨基衍生物，是有效的HCV RNA依赖性RNA聚合酶抑制剂，靶向NS5B聚合酶。 了解更多
  32. MK-5172
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    MK-5172

    Catalog No. A13787
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    HCV NS3/4a 抑制剂
    MK-5172是丙型肝炎病毒NS3/4a蛋白酶的选择性抑制剂，在基因型和耐药变异中具有广泛的活性。 了解更多
  33. GS-9256
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    GS-9256

    Catalog No. A13526
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    HCV NS3 抑制剂
    GS-9451是一种有效的大环HCV NS3 PI，在3天单药治疗后，HCV RNA的中值最大变化达到3.6 log10 IU/mL（范围从-4.7 log10到-3.1 log10 IU/mL）。 I期HCV基因型1感染。 了解更多
  34. BI207127 (Deleobuvir)
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    BI207127 (Deleobuvir)

    Catalog No. A13414
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    HCV NS5B polymerase 抑制剂
    BI 207127是非核苷类丙型肝炎病毒NS5B聚合酶抑制剂，用于治疗丙型肝炎。 了解更多
  35. Narlaprevir
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    Narlaprevir

    Catalog No. A11506
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    NS3 protease 抑制剂
    Narlaprevir是一种有效的、选择性的、口服生物可利用的ns3蛋白酶抑制剂(Ki=6 nM；EC90=40 nM)。 了解更多
  36. Glecaprevir
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    Glecaprevir

    Catalog No. A16948
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    HCV NS3/4A protease 抑制剂
    Glecaprevir，也称为ABT-493和A-1282576，是一种新型的HCV NS3/4A蛋白酶抑制剂，IC50值在3.5至11.3 nM之间。 了解更多
  37. BMS-806 (BMS 378806)
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    BMS-806 (BMS 378806)

    Catalog No. A11201
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    HIV Entry 抑制剂
    BMS-806，也称为BMS-378806，选择性抑制HIV-1 gp120与CD4受体结合，EC50为0.85-26.5 nM。通过阻止HIV进入人体细胞而发挥作用。可阻断宿主细胞CD4与病毒gp120蛋白的结合，因此可抑制HIV-1感染的第一步。 了解更多
  38. Ritonavir
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    Ritonavir

    Catalog No. A10799
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    HIV Protease 抑制剂
    Ritonavir是一种蛋白酶抑制剂，具有抗人类免疫缺陷病毒1型(hiv-1)的活性。蛋白酶抑制剂阻断hiv中被称为蛋白酶的部分，利托那韦抑制hiv病毒蛋白酶，这种蛋白酶防止gag-pol多蛋白的裂解，从而产生非感染性的未成熟病毒颗粒。 了解更多
  39. Lopinavir (ABT-378)
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    Lopinavir (ABT-378)

    Catalog No. A10537
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    HIV Protease 抑制剂
    Lopinavir (ABT-378)是HIV蛋白酶的抑制剂。 了解更多
  40. Atazanavir sulfate (BMS-232632-05)
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    Atazanavir sulfate (BMS-232632-05)

    Catalog No. A10096
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    HIV Protease 抑制剂
    Atazanavir sulfate (BMS-232632-05)是蛋白酶抑制剂（PI）类的抗逆转录病毒药物。是一种高选择性的 HIV-1蛋白酶抑制剂。 了解更多
  41. Atazanavir
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    Atazanavir

    Catalog No. A10097
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    HIV Protease 抑制剂
    Atazanavir是一种氮杂肽及HIV-蛋白酶抑制剂，常与其他抗HIV药物结合，用于治疗HIV感染以及获得性免疫缺乏综合征。 了解更多
  42. Saquinavir
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    Saquinavir

    Catalog No. A11378
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    HIV Protease 抑制剂
    Saquinavir是蛋白酶抑制剂。蛋白酶是将蛋白质分子切割成更小片段的酶。Saquinavir抑制HIV-1和HIV-2蛋白酶。 了解更多
  43. Darunavir Ethanolate (Prezista)
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    Darunavir Ethanolate (Prezista)

    Catalog No. A11853
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    HIV protease 抑制剂
    Darunavir Ethanolate (Prezista)是一种HIV蛋白酶抑制剂。 了解更多
  44. GSK2838232A
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    GSK2838232A

    Catalog No. A13156
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    HIV maturation 抑制剂
    GSK2838232是一种新型的人类免疫病毒（HIV）成熟抑制剂，正在开发用于治疗慢性HIV感染。 了解更多
  45. Fosamprenavir
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    Fosamprenavir

    Catalog No. A12583
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    HIV protease 抑制剂
    Fosamprenavir是amprenavir的前药，amprenavir是人类免疫缺陷病毒（HIV）蛋白酶的抑制剂。 了解更多
  46. Bevirimat
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    Bevirimat

    Catalog No. A14194
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    HIV-1 maturation 抑制剂
    Bevirimat (PA-457,MPC-4326,YK FH312) 是HIV-1病毒颗粒成熟抑制剂。 了解更多
  47. Temsavir (BMS 626529)
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    Temsavir (BMS 626529)

    Catalog No. A14148
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    HIV-1 attachment 抑制剂
    BMS-626529是有效的HIV-1附着抑制剂。BMS-663068也是BMS-626529的膦酰氧甲基前药，其靶向HIV-1 gp120，并阻止其与CD4(+)T细胞结合。 了解更多
  48. Nelfinavir Mesylate
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    Nelfinavir Mesylate

    Catalog No. A14259
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    HIV protease 抑制剂
    Nelfinavir Mesylate是一种有效的HIV蛋白酶抑制剂，Ki为2 nM。 了解更多
  49. Pepstatin A
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    Pepstatin A

    Catalog No. A14262
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    aspartic protease 抑制剂
    Pepstatin A是一种有效的天冬氨酸蛋白酶抑制剂，还可以抑制HIV复制。 了解更多
  50. BMS-663068 (Fostemsavir)
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    BMS-663068 (Fostemsavir)

    Catalog No. A15025
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    HIV-1 attachment 抑制剂
    BMS-663068 (Fostemsavir)是治疗HIV-1感染的HIV-1附着抑制剂。 了解更多

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