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Membrane Transporters/Ion Channels

产品 101 到 150 共 317个

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  1. Farampator
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    Farampator

    Catalog No. A13798
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    AMPA receptor modulator
    Farampator是一种AMPA受体正调节剂，它可以改善短期记忆，但会损害情景记忆。 了解更多
  2. Cyclothiazide
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    Cyclothiazide

    Catalog No. A13700
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    AMPA desensitization 抑制剂
    Cyclothiazide是苯并噻二叠氮，可作为AMPA受体的增效剂，正向调节其对谷氨酸的响应（EC50 = 3.8 M）。 了解更多
  3. CNQX
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    CNQX

    Catalog No. A16109
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    AMPA/kainate 拮抗剂
    CNQX是一种竞争性的非NMDA谷氨酸受体拮抗剂（AMPA和海藻酸酯受体的IC50分别为0.3和1.5 uM，而NMDA受体的IC50 = 25 uM）。 了解更多
  4. CNQX disodium salt
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    CNQX disodium salt

    Catalog No. A16110
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    AMPA/kainate 拮抗剂
    CNQX disodium salt，AMPA/海藻酸酯拮抗剂CNQX（GLXC-11053）的水溶性形式。 了解更多
  5. GYKI53655 Hydrochloride
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    GYKI53655 Hydrochloride

    Catalog No. A17032
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    AMPA 拮抗剂
    GYKI53655 Hydrochloride是一种非竞争性AMPA和海藻酸酯受体拮抗剂。 了解更多
  6. CX546
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    CX546

    Catalog No. A21923
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    positive AMPAR modulator
    CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. 了解更多
  7. CFM-2
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    CFM-2

    Catalog No. A21930
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    non-competitive AMPAR antagonist
    CFM-2 is a selective non-competitive AMPAR antagonist. 了解更多
  8. (S)-Willardiine
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    (S)-Willardiine

    Catalog No. A21957
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    AMPA/kainate receptors agonist
    (S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. 了解更多
  9. Becampanel
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    Becampanel

    Catalog No. A21194
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    AMPA antagonist
    Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent. 了解更多
  10. Tezampanel
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    Tezampanel

    Catalog No. A15259
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    AMPA 拮抗剂
    Tezampanel是AMPA和离子型谷氨酸受体的海藻酸盐家族的拮抗剂，对海藻酸盐受体的GluR5亚型具有选择性。 了解更多
  11. YM90K hydrochloride
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    YM90K hydrochloride

    Catalog No. A15495
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    AMPA 拮抗剂
    YM90K hydrochloride是一种选择性AMPA受体拮抗剂，在局部缺血后给药后，可延迟整体缺血模型中的神经元死亡和局部缺血模型中的脑梗塞。 了解更多
  12. Talampanel
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    Talampanel

    Catalog No. A15515
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    AMPA/kainate receptor 拮抗剂
    Talampanel是AMPA受体的非竞争性拮抗剂，具有抗癫痫活性。 了解更多
  13. CP 465022 hydrochloride
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    CP 465022 hydrochloride

    Catalog No. A13321
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    AMPA 拮抗剂
    CP 465022 hydrochloride是一种选择性的非竞争性AMPA拮抗剂，在大鼠皮质神经元中的IC50为25 nM，显示出有效的抗惊厥活性。 了解更多
  14. JNJ-61432059
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    JNJ-61432059

    Catalog No. A20209
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    AMPAR negative modulator
    JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. 了解更多
  15. SYM2206
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    SYM2206

    Catalog No. A20843
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    AMPA receptor antagonist
    SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist. 了解更多
  16. PF-4778574
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    PF-4778574

    Catalog No. A21157
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    AMPA receptor positive allosteric modulator
    PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models. 了解更多
  17. Fanapanel
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    Fanapanel

    Catalog No. A21200
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    AMPA/kainate antagonist
    Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. 了解更多
  18. (S)-(-)-5-Fluorowillardiine
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    (S)-(-)-5-Fluorowillardiine

    Catalog No. A21337
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    AMPAR agonist
    (S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist. 了解更多
  19. Naspm trihydrochloride
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    Naspm trihydrochloride

    Catalog No. A21437
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    CP-AMPA receptors antagonist
    Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. 了解更多
  20. Fanapanel hydrate
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    Fanapanel hydrate

    Catalog No. A21668
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    AMPA/kainate antagonist
    Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. 了解更多
  21. Mibampator
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    Mibampator

    Catalog No. A21717
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    AMPA receptors potentiator
    Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors. 了解更多
  22. Philanthotoxin 74 dihydrochloride
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    Philanthotoxin 74 dihydrochloride

    Catalog No. A21739
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    AMPAR antagonist
    Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. 了解更多
  23. PEPA
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    PEPA

    Catalog No. A21904
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    AMPA receptors allosteric modulator
    PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. 了解更多
  24. CMPDA
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    CMPDA

    Catalog No. A21909
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    AMPA receptors positive allosteric modulator
    CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ?? 4.2 nM/63.4 ?? 5.6 nM for GluA2i/GluA2o receptor. 了解更多
  25. Naspm
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    Naspm

    Catalog No. A21919
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    AMPA (CP-AMPA) receptors antagonist
    Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. 了解更多
  26. AR-C155858
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    AR-C155858

    Catalog No. A11293
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    MCT1 and MCT2 抑制剂
    AR-C155858是单羧酸转运蛋白mct1和mct2的有效抑制剂，它们与涉及跨膜螺旋7-10的细胞内位点结合。 了解更多
  27. CHC
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    CHC

    Catalog No. A13372
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    MCT 抑制剂
    CHC是单羧酸转运（MCT）抑制剂。在神经胶质瘤中具有抗肿瘤和抗血管生成活性；降低U251细胞的糖酵解代谢，迁移和侵袭。 了解更多
  28. AZD-3965
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    AZD-3965

    Catalog No. A14186
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    MCT1 抑制剂
    AZD-3965（AZD3965）是具有1.6 nM结合亲和力的单羧酸盐转运蛋白1（MCT1）的选择性抑制剂，是MCT2的6倍选择性，在10μM时不抑制MCT4。 了解更多
  29. AR-C117977
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    AR-C117977

    Catalog No. A14360
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    MCT1 抑制剂
    AR-C117977是一种有效的MCT1抑制剂，可以降低体内和体外的免疫应答，维持长期移植物存活，并诱导操作耐受性。 了解更多
  30. 7ACC2
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    7ACC2

    Catalog No. A15785
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    MCT 抑制剂
    7ACC2是一种新型有效的MCT抑制剂，IC50为11 nM，可抑制[14C]-乳酸盐涌入。针对癌细胞中乳酸转运的新型抗肿瘤治疗。 了解更多
  31. 7ACC1
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    7ACC1

    Catalog No. A15810
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    MCT 抑制剂?
    7ACC1在富含乳酸的肿瘤微环境中选择性干扰乳酸通量；在表达MCT1和MCT4转运蛋白的肿瘤细胞中，乳酸抑制乳酸盐流入，但不流出。 了解更多
  32. UK 5099
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    UK 5099

    Catalog No. A13038
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    MCT 抑制剂
    UK 5099是质膜单羧酸盐转运蛋白（MCT）和线粒体丙酮酸载体（MPC）的有效抑制剂。抑制丙酮酸依赖性的氧气消耗，IC50为50 nM。 了解更多
  33. BAY-8002
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    BAY-8002

    Catalog No. A18611
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    MCT1 inhibitor
    BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity. 了解更多
  34. Dapagliflozin (BMS512148)
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    Dapagliflozin (BMS512148)

    Catalog No. A10285
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    SGLT2 抑制剂
    Dapagliflozin (BMS512148)抑制钠-葡萄糖转运蛋白（SGLT2）的亚型2，后者负责肾脏中至少90％的葡萄糖重吸收。 了解更多
  35. Canagliflozin
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    Canagliflozin

    Catalog No. A11100
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    SGLT2 抑制剂
    canagliflozin是2型亚钠葡萄糖转运蛋白（SGLT2）的抑制剂,作用于hSGLT2，无细胞试验中IC50为2.2 nM，比作用于hSGLT1选择性高413倍。 了解更多
  36. EGT1442
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    EGT1442

    Catalog No. A10155
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    SGLT2 抑制剂
    EGT1442是有效的选择性SGLT2抑制剂。 了解更多
  37. Empagliflozin
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    Empagliflozin

    Catalog No. A12440
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    Empagliflozin是一种有效的选择性葡萄糖钠共转运蛋白-2抑制剂，目前正在开发中，用于治疗2型糖尿病。 了解更多
  38. LX-4211
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    LX-4211

    Catalog No. A12680
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    SGLT 抑制剂?
    LX4211是双重SGLT1/SGLT2抑制剂。 了解更多
  39. Tofogliflozin
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    Tofogliflozin

    Catalog No. A12690
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    SGLT2 抑制剂
    Tofogliflozin是亚型2钠葡萄糖转运蛋白（SGLT2）的抑制剂，可引起肾脏中至少90％的葡萄糖重吸收。 了解更多
  40. Remogliflozin
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    Remogliflozin

    Catalog No. A13971
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    SGLT2 抑制剂
    Remogliflozin抑制钠葡萄糖转运蛋白（SGLT2），后者负责肾脏中的葡萄糖重吸收。 了解更多
  41. Ipragliflozin
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    Ipragliflozin

    Catalog No. A13556
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    SGLT2 抑制剂
    Ipragliflozin是一种高效的选择性SGLT2抑制剂，IC50为2.8 nM。SGLT1/3/4/5/6的效力很小且没有效力。 了解更多
  42. Luseogliflozin
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    Luseogliflozin

    Catalog No. A13476
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    SGLT2 抑制剂
    Luseogliflozin是由Taisho Pharmaceutical开发的一种口服活性第二代钠葡萄糖共转运蛋白2（SGLT2）抑制剂，用于治疗2型糖尿病（T2DM）患者。 了解更多
  43. T-1095
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    T-1095

    Catalog No. A15463
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    Na+-glucose transporter 抑制剂
    T-1095是Na+-葡萄糖共转运蛋白（SGLTs）的有效和选择性抑制剂。 了解更多
  44. Canagliflozin hemihydrate
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    Canagliflozin hemihydrate

    Catalog No. A16817
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    SGLT2 抑制剂
    Canagliflozin hemihydrate是半水形式的卡格列嗪，是一种SGLT2抑制剂，在无细胞检测中hSGLT2的IC50为2.2 nM，其选择性比hSGLT1高413倍。 了解更多
  45. Ertugliflozin L-pyroglutamic acid
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    Ertugliflozin L-pyroglutamic acid

    Catalog No. A18054
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    SGLT inhibitor
    Ertugliflozin pidolate belongs to the class of potent and selective inhibitors of the sodium-dependent glucose cotransporters (SGLT), more specifically the type 2 which is responsible for about 90% of the glucose reabsorption from glomerulus. 了解更多
  46. SGL5213
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    SGL5213

    Catalog No. A18723
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    SGLT1 抑制剂
    SGL5213 is a potent, oral active and low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, with IC50 values of 29 nM and 20 nM for hSGLT1 and hSGLT2, respectively. 了解更多
  47. Dapagliflozin impurity
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    Dapagliflozin impurity

    Catalog No. A19103
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    SGLT2 抑制剂
    Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor. 了解更多
  48. Licogliflozin
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    Licogliflozin

    Catalog No. A12828
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    SGLT1/SGLT2 抑制剂
    Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor. 了解更多
  49. Ivermectin
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    Ivermectin

    Catalog No. A10490
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    Ivermectin是一种广谱抗寄生虫阿维菌素药物。 了解更多
  50. Talniflumate
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    Talniflumate

    Catalog No. A13339
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    CaCC blocker
    Talniflumate是一种钙激活的氯离子通道（CaCC）（hCLCA1/mCLCA3）阻滞剂；在细胞培养和动物模型中减少粘蛋白的合成和释放。 了解更多

产品 101 到 150 共 317个

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分类
  1. ATPase (22)
  2. CFTR (16)
  3. Calcium Channels (47)
  4. Sodium Channels (44)
  5. Potassium Channels (38)
  6. Chloride Channels (7)
  7. SGLT (15)
  8. Monocarboxylate transporters (MCT) (8)
  9. AMPA receptor (33)
  10. P-gp (19)
  11. CRM1 (6)
  12. TRP Channel (23)
  13. TRPV (15)
  14. Glutamate (EAAT) Transporters (1)
  15. Serotonin Transporter (3)
  16. Proton Pump (7)
  17. OCT (4)
  18. NCX (5)
  19. BCRP (6)
  20. MRP (1)
  21. Na+/H+ Exchanger (4)
  22. Monoamine Transporter (3)
作用机制
  1. Inhibitor (抑制剂) (122)
  2. Agonist (激动剂) (12)
  3. Antagonist (拮抗剂) (36)
  4. Activator (激活剂) (22)
  5. Modulator (调节剂) (15)
  6. Blocker (阻断剂) (47)
  7. Inducer (诱导剂) (3)
  8. Potentiator (增强剂) (5)
靶点
  1. DNMT (1)
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