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Membrane Transporters/Ion Channels

产品 251 到 300 共 317个

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  1. Nimodipine
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    Nimodipine

    Catalog No. A10645
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    Calcium Channel 抑制剂
    Nimodipine是一种L型Ca2+通道阻滞剂。 了解更多
  2. BAPTA tetrapotassium
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    BAPTA tetrapotassium

    Catalog No. A13989
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    Selective calcium chelator
    BAPTA tetrapotassium是一种选择性钙螯合剂，对Ca2+的亲和力大于Mg2+。 了解更多
  3. BAPTA/AM
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    BAPTA/AM

    Catalog No. A14023
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    Selective calcium chelator
    BAPTA/AM是一种细胞内钙螯合剂，可通过脂氧合酶介导的自由基在小鼠皮层培养物中诱导延迟性坏死。 了解更多
  4. Dantrolene
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    Dantrolene

    Catalog No. A13928
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    Ca2+ release 抑制剂
    Dantrolene是一种肌肉松弛剂，其作用可能是通过消除对ryanodine受体的作用来消除肌肉细胞中的兴奋-收缩偶联。 了解更多
  5. Atagabalin
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    Atagabalin

    Catalog No. A13402
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    Atagabalin与加巴喷丁相关，加巴喷丁同样与α结合。2β钙通道(1和2)。 了解更多
  6. Berbamine
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    Berbamine

    Catalog No. A14794
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    Calcium channel blocker
    Berbamine是钙通道阻滞剂。 了解更多
  7. (S)-Amlodipine
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    (S)-Amlodipine

    Catalog No. A14935
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    Calcium channel blocker
    (S)-Amlodipine是氨氯地平的(S)-对映体，具有活性的二氢吡啶钙通道阻滞剂主要存在于(-)-异构体中。 了解更多
  8. NNC 55-0396
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    NNC 55-0396

    Catalog No. A15188
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    Calcium channel blocker
    NNC 55-0396是Mibefradil衍生物，是一种高度选择性的T型钙通道阻滞剂；分别在INS-1细胞中抑制Cav3.1 T型通道和HVA电流的IC50值为6.8和> 100μM。 了解更多
  9. NP118809
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    NP118809

    Catalog No. A15192
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    N-type calcium channel blocker
    NP118809是有效的N型钙通道阻滞剂（IC50 = 0.11 uM）；对L型钙通道的选择性好。 了解更多
  10. NS6180
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    NS6180

    Catalog No. A12405
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    K(Ca) 3.1 channel blocker
    NS6180是一种新型有效的选择性KCa3.1通道抑制剂（IC50 = 9 nM），可防止T细胞活化和炎症反应。 了解更多
  11. Bay K 8644
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    Bay K 8644

    Catalog No. A15875
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    Calcium Channel Activator
    Bay K 8644是一种有效的L型Ca2+通道选择性激活剂，IC50为17.3 nM。 了解更多
  12. Mibefradil dihydrochloride
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    Mibefradil dihydrochloride

    Catalog No. A12482
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    Calcium channel blocker
    Mibefradil dihydrochloride是钙通道阻滞剂，对T型Ca2+通道具有中等选择性，对T型和L型通道的IC50值分别为2.7 uM和18.6 uM。 了解更多
  13. Dantrolene sodium Hemiheptahydrate
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    Dantrolene sodium Hemiheptahydrate

    Catalog No. A16146
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    Dantrolene sodium是一种骨骼肌松弛剂，其通过干扰肌肉纤维中的激发-收缩偶联起作用。 了解更多
  14. YM-58483
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    YM-58483

    Catalog No. A16346
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    CRAC channel 抑制剂
    YM-58483是CRAC通道和随后的Ca2+信号的第一个选择性抑制剂。 了解更多
  15. Chlorocresol
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    Chlorocresol

    Catalog No. A16444
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    Chlorocresol是ryanodine受体的活化剂。 了解更多
  16. Cinepazide maleate
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    Cinepazide maleate

    Catalog No. A16454
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    Cinepazide maleate是Cinepazide的马来酸盐形式，其为血管扩张剂。 了解更多
  17. Cinnarizine
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    Cinnarizine

    Catalog No. A16455
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    calcium channel blocker
    Cinnarizine是哌嗪的药物衍生物，其特征在于抗组胺药和钙通道阻滞剂。 了解更多
  18. Aranidipine
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    Aranidipine

    Catalog No. A18291
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    Calcium channel antagonist
    Aranidipine (MPC1304) is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects. 了解更多
  19. ABT-639
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    ABT-639

    Catalog No. A12330
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    T-type Ca2+ channel blocker
    ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. 了解更多
  20. Ca2+ channel agonist 1
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    Ca2+ channel agonist 1

    Catalog No. A12186
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    Ca2+ channel agonist/CDK2 inhibitor
    Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction. 了解更多
  21. Barnidipine
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    Barnidipine

    Catalog No. A21940
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    L-type calcium antagonist
    Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors. 了解更多
  22. Dantrolene sodium
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    Dantrolene sodium

    Catalog No. A17644
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    Calcium channel proteins inhibitor
    Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. 了解更多
  23. Caldaret
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    Caldaret

    Catalog No. A13148
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    intracellular Ca2+ handling modulator
    Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition. 了解更多
  24. ABT-639 hydrochloride
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    ABT-639 hydrochloride

    Catalog No. A12571
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    T-type Ca2+ channel blocker
    ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker. 了解更多
  25. (S)-(-)-Bay-K-8644
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    (S)-(-)-Bay-K-8644

    Catalog No. A21164
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    L-type Ca2+ channel agonist
    (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM). 了解更多
  26. TTA-Q6
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    TTA-Q6

    Catalog No. A21360
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    T-type Ca2+ channel antagonist
    TTA-Q6 is a selective T-type Ca2+ channel antagonist, used in the neurological disease. 了解更多
  27. TTA-Q6(isomer)
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    TTA-Q6(isomer)

    Catalog No. A21724
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    T-type Ca2+ channel antagonist
    TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca2+ channel antagonist. 了解更多
  28. JTV-519 free base
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    JTV-519 free base

    Catalog No. A21846
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    Ca2+-dependent blocker
    TV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties. 了解更多
  29. GV-58
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    GV-58

    Catalog No. A21966
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    N- and P/Q-type Ca2+ channels agonist
    GV-58 is a potent, selective N- and P/Q-type Ca2+ channels agonist with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel; 20-fold less potent CDK inhibitor activity. 了解更多
  30. Oridonin (Isodonol)
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    Oridonin (Isodonol)

    Catalog No. A10675
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    CFTR 抑制剂
    Oridonin (Isodonol)是一种从鼠李木中分离出来的Entkaurane二萜类化合物，是一种重要的传统中草药。 了解更多
  31. CFTRinh-172
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    CFTRinh-172

    Catalog No. A12897
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    CFTR 抑制剂
    CFTRinh-172是电压无关的选择性CFTR抑制剂。在2分钟内可逆地抑制CFTR短路电流的 Ki 值为300 nM。 了解更多
  32. KM 11060
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    KM 11060

    Catalog No. A15843
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    F508del-CFTR trafficking corrector
    KM 11060纠正了F508del-CFTR的运输，增加了质膜上功能性CFTR的量（?75％）并抑制了PDE5的活性。 了解更多
  33. PG 01
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    PG 01

    Catalog No. A18315
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    CFTR potentiator
    PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. PG 01 is effective on G970R although with a significant decrease in potency relative to E193K and δF508. 了解更多
  34. CFTR corrector 2
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    CFTR corrector 2

    Catalog No. A18528
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    CFTR corrector
    CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933. 了解更多
  35. GLPG2451
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    GLPG2451

    Catalog No. A18919
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    CFTR potentiator
    GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM. 了解更多
  36. Ivacaftor benzenesulfonate
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    Ivacaftor benzenesulfonate

    Catalog No. A15132
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    CFTR potentiator
    Ivacaftor benzenesulfonate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment. 了解更多
  37. Ivacaftor hydrate
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    Ivacaftor hydrate

    Catalog No. A15133
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    CFTR potentiator
    Ivacaftor hydrate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment. 了解更多
  38. PTC124 (Ataluren)
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    PTC124 (Ataluren)

    Catalog No. A10758
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    CFTR 抑制剂
    PTC124也称为Ataluren，是CFTR-G542X无意义等位基因抑制剂。 了解更多
  39. VX-770 (Ivacaftor)
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    VX-770 (Ivacaftor)

    Catalog No. A10985
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    CFTR activator
    VX-770 (Ivacaftor)被称为CFTR增强剂，靶向作用于G551D-CFTR和F508del-CFTR，在fisher大鼠甲状腺细胞中EC50分别为100 nM和25 nM。 了解更多
  40. VX-809 (Lumacaftor)
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    VX-809 (Lumacaftor)

    Catalog No. A10986
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    CFTR modulator
    VX-809 (Lumacaftor)是用于治疗囊性纤维化（CF）的第二种口服研究候选化合物，通过促进突变型CFTR(F508del-CFTR)的成熟，从而纠正囊性纤维症中常见的CFTR突变，在fisher大鼠甲状腺细胞中EC50为0.1 μM。 了解更多
  41. VX-661
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    VX-661

    Catalog No. A12519
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    CFTR corrector
    VX-661是另一种正在开发中的用于治疗囊性纤维化的囊性纤维化跨膜电导调节器（CFTR）校正器。 了解更多
  42. Glyburide
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    Glyburide

    Catalog No. A10433
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    K+ channel and CFTR Cl- channel blocker
    Glyburide (Glibenclamide) 是一种抗糖尿病化合物，是一类磺脲类药物。 了解更多
  43. IOWH032
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    IOWH032

    Catalog No. A13511
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    CFTR 抑制剂
    IOWH032是CFTR抑制剂。 了解更多
  44. CFTR-Inhibitor-II
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    CFTR-Inhibitor-II

    Catalog No. A13723
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    CFTR 抑制剂
    CFTR inhibitor II,也称为GlyH-101，是一种甘氨酸酰肼，可选择性和可逆地阻断CFTR通道（Ki = 4.3 uM）。 了解更多
  45. PPQ-102
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    PPQ-102

    Catalog No. A13000
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    CFTR chloride channel 抑制剂
    PPQ-102是一种化合物，其靶向cftr的胞内核苷酸结合结构域，并以电压依赖性和可逆的方式抑制cftr介导的氯离子电流。 了解更多
  46. Brefeldin A
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    Brefeldin A

    Catalog No. A11156
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    Protein translocation 抑制剂
    Brefeldin A阻断ADP-核糖基化因子与高尔基体的结合并抑制GDP-GTP交换。 了解更多
  47. PF 3716556
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    PF 3716556

    Catalog No. A11408
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    ATPase 拮抗剂
    PF 3716556是H+,K+-ATPase酶抑制剂(在人类重组离子渗漏试验中PIC50 = 6)。 了解更多
  48. Sodium orthovanadate
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    Sodium orthovanadate

    Catalog No. A10854
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    protein tyrosine phosphatases inhibitor
    Sodium orthovanadate是化合物Na3VO4。 它是蛋白质酪氨酸磷酸酶，碱性磷酸酶和许多ATPase的抑制剂，很可能充当磷酸盐类似物。 了解更多
  49. Artemisinin
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    Artemisinin

    Catalog No. A10086
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    Artemisinin及其衍生物是一类药物，在所有当前针对恶性疟原虫疟疾的药物中具有最快的作用。 了解更多
  50. Ciclopirox
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    Ciclopirox

    Catalog No. A10213
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    Ciclopirox是一种合成的抗真菌药物。它可以抑制酵母糠醛马拉丝霉的生长，并通过中断Na+K+ ATPase来抑制膜转移系统，从而发挥作用。 了解更多

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分类
  1. ATPase (22)
  2. CFTR (16)
  3. Calcium Channels (47)
  4. Sodium Channels (44)
  5. Potassium Channels (38)
  6. Chloride Channels (7)
  7. SGLT (15)
  8. Monocarboxylate transporters (MCT) (8)
  9. AMPA receptor (33)
  10. P-gp (19)
  11. CRM1 (6)
  12. TRP Channel (23)
  13. TRPV (15)
  14. Glutamate (EAAT) Transporters (1)
  15. Serotonin Transporter (3)
  16. Proton Pump (7)
  17. OCT (4)
  18. NCX (5)
  19. BCRP (6)
  20. MRP (1)
  21. Na+/H+ Exchanger (4)
  22. Monoamine Transporter (3)
作用机制
  1. Inhibitor (抑制剂) (122)
  2. Agonist (激动剂) (12)
  3. Antagonist (拮抗剂) (36)
  4. Activator (激活剂) (22)
  5. Modulator (调节剂) (15)
  6. Blocker (阻断剂) (47)
  7. Inducer (诱导剂) (3)
  8. Potentiator (增强剂) (5)
靶点
  1. DNMT (1)
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