“angiotensin converting enzyme ace”的搜索结果
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ACE 抑制剂
Enalapril maleate是一种血管紧张素转换酶（ACE）抑制剂，用于治疗高血压和某些类型的慢性心力衰竭。
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ACE 抑制剂
Fosinopril sodium是一种血管紧张素转换酶(ACE)抑制剂，用于治疗高血压和某些类型的慢性心力衰竭。
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angiotensin receptor-neprilysin 抑制剂
LCZ696 (Valsartan)是一种生物利用型双效血管紧张素受体-中性溶血素抑制剂（ARNi），用于治疗高血压和心力衰竭。
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E2 ubiquitin conjugating enzyme 抑制剂
Bay 11-7821是TNF-α刺激的IκBα磷酸化的不可逆抑制剂。
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- Ali Nasrollahzadeh, .et al. Blockade of Nuclear Factor-??b (NF-??b) Pathway Using Bay 11-7082 Enhances Arsenic Trioxide-Induced Antiproliferative Activity in U87 Glioblastoma Cells, Rep Biochem Mol Biol, 2022, Jan;10(4):602-613 PMID: 35291620
- Ali Nasrollahzadeh, .et al. Arsenic trioxide and BIBR1532 synergistically inhibit breast cancer cell proliferation through attenuation of NF-κB signaling pathway, Life Sci, 2020, Jul 6;257:118060 PMID: 32645343
- Momeny M, .et al. Blockade of nuclear factor-κB (NF-κB) pathway inhibits growth and induces apoptosis in chemoresistant ovarian carcinoma cells, Int J Biochem Cell Biol, 2018, Jun;99:1-9 PMID: 29567488
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GSK-3 抑制剂
BIO-acetoxime是一种有效的双重GSK3α/β抑制剂，IC50为10 nM，选择性比CDK5/p25，CDK2/cyclin A和 CDK1/cyclin B高240倍以上。
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acetyl-CoA carboxylase 抑制剂
CP-640186是一种同工酶非选择性乙酰辅酶a羧化酶(acc)抑制剂，其ic50s分别为53 nm和61nm；与cp-610431相比，代谢稳定性提高。
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PKC 抑制剂
马鞭草苷是从马Lan丹中提取的，可作为ATP竞争性PKC抑制剂，IC50为25 ?M，具有抗肿瘤，抗炎和抗癌的疼痛活性。
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COX 抑制剂
Acetaminophen (paracetamol) 是选择性环氧合酶-2 (COX-2) 的抑制剂，IC50 值为 25.8 μM。Acetaminophen 是一种有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。它是广泛使用的解热和止痛药。
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- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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NADPH-oxidase 抑制剂
Apocynin (Acetovanillone)是NADPH氧化酶抑制剂。
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- Liling Su, .et al. Disruption of mitochondrial redox homeostasis as a mechanism of antimony-induced reactive oxygen species and cytotoxicity, Ecotoxicol Environ Saf, 2022, Jun 1;237:113519 PMID: 35453021
- Shimizu S, .et al. Angiotensin II, a stress-related neuropeptide in the CNS, facilitates micturition reflex in rats, Br J Pharmacol, 2018, Sep;175(18):3727-3737 PMID: 29981238
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HDAC 抑制剂
CI994 (Tacedinaline)是一种组蛋白脱乙酰基酶（HDAC）抑制剂，可在活细胞中诱导组蛋白超乙酰化。
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AMPA Receptor 抑制剂
Aniracetam是一种安非他命，属于消旋体化学类别的促智药，据称比吡乙酰胺更有效。
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cytochrome P4503A4 抑制剂
Clarithromycin是一种大环内酯类抗生素。它通过干扰细菌的蛋白质合成来防止细菌生长。
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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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BACE1 抑制剂
LY2811376是第一种可口服的非肽类BACE1抑制剂，可在动物体内产生显着的Aβ降低作用。
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COX 抑制剂
Acemetacin (Emflex)是一种非甾体类抗炎药，是吲哚美辛的乙醇酸酯，是一种环加氧酶抑制剂。
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Hydrogen peroxide 抑制剂
Acetanilide在过氧化氢中用作抑制剂，并用于稳定纤维素酯清漆。
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Gamma-secretase 抑制剂
Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。
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- Yesuvadian R, .et al. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study., Biochem Biophys Res Commun., 2014, May 16;447(4):590-5 PMID: 24747079
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HMG-CoA Reductase 抑制剂
Clinofibrate是一种脂质清除剂，似乎可以改变脂质代谢，减少类固醇诱导的骨细胞内脂质堆积。它还可以有效降低血浆纤维蛋白原水平。抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)（羟甲基戊二酰辅酶A还原酶），IC50为0.47 mM。
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CETP 抑制剂
Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。
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CYP17 抑制剂
Abiraterone Acetate是Abiraterone的醋酸盐形式，是一种甾体类细胞色素CYP17抑制剂。
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