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43 个项目
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AZD3839 free base
Catalog No. A21606 BACE1 inhibitorAZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多 -
Umibecestat (CNP520)
Catalog No. A18987 BACE-1 inhibitorUmibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. 了解更多 -
Acetyllovastatin
Catalog No. A19111 AChE inhibitorAcetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC50 of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines. 了解更多 -
PF-06751979
Catalog No. A20066 BACE1 inhibitorPF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay. 了解更多 -
(±)-Huperzine A
Catalog No. A21003 AChE inhibitor(??)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). 了解更多 -
Oxotremorine M iodide
Catalog No. A21977 mAChR agonistOxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. 了解更多 -
(Rac)-VU 6008667
Catalog No. A21939 mAChR M5 negative allosteric modulator(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration. 了解更多 -
Varenicline Hydrochloride
Catalog No. A21539 α4β2 nAChR partial agonistVarenicline Hydrochloride (CP 526555 hydrochloride) is a high affinity, selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist and full α7 nAChR agonist. 了解更多 -
β-Secretase Inhibitor IV
Catalog No. A21346 BACE-1 inhibitorβ-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. 了解更多 -
Rapacuronium bromide
Catalog No. A21119 mAChR modulatorRapacuronium bromide is an allosteric modulator of muscarinic acetylcholine receptor (mAChR). 了解更多 -
BACE1-IN-1
Catalog No. A12183 BACE1 inhibitorBACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. 了解更多 -
Tiotropium Bromide
Catalog No. A10934 muscarinic acetylcholine receptor (mAChR) antagonistTiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. 了解更多 -
Acamprosate calcium
Catalog No. A11308 GABA receptor agonistAcamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. 了解更多 -
Lanabecestat
Catalog No. A12282 BACE1 inhibitorLanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多 -
Galanthamine
Catalog No. A12483 AChE inhibitorGalanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM. 了解更多 -
BACE1-IN-4
Catalog No. A18462 BACE1 inhibitorBACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer??s disease. 了解更多 -
Anisodamine
Catalog No. A18215 alpha-1 adrenergic receptors / mAChRs inhibitorAnisodamine is an inhibitor of alpha-1 adrenergic receptors and mAChRs isolated from Chinese solanacea plant. 了解更多 -
Edrophonium chloride
Catalog No. A17794 acetylcholinesterase inhibitorEdrophonium Chloride, also known as Tensilon, is an acetylcholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. Edrophonium Chloride has also been used as an antidote to curare principles. 了解更多 -
Aceclofenac
Catalog No. A17433 COX-2 抑制剂Aceclofenac is a cyclooxygenase-2 inhibitor used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. 了解更多 -
Tacrine HCl
Catalog No. A17374 AChE & butyrylcholinesterase inhibitorTacrine is a derivative of aminoacridine that functions as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively). 了解更多 -
Acetylcholine iodide
Catalog No. A16390 Acetylcholine iodide是一种神经递质，存在于神经肌肉接头，植物神经节，副交感神经效应接头，交感神经效应接头的子集以及中枢神经系统的许多部位。 了解更多 -
STO-609 acetate
Catalog No. A16345 -
Verubecestat (MK-8931)
Catalog No. A16113 β-secretase/BACE1 抑制剂Verubecestat (MK-8931)是一种有效的选择性β-分泌酶抑制剂，是BACE1蛋白抑制剂或Beta-site APP裂解酶1抑制剂。 了解更多 -
Begacestat (GSI-953)
Catalog No. A11258 -
Timosaponin b-II
Catalog No. A14591 -
Acetaminophen
Catalog No. A10030 COX 抑制剂Acetaminophen (paracetamol) 是选择性环氧合酶-2 (COX-2) 的抑制剂，IC50 值为 25.8 μM。Acetaminophen 是一种有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。它是广泛使用的解热和止痛药。 了解更多 -
Oxybutynin
Catalog No. A10684 Oxybutynin (Ditropan)是一种抗胆碱能药物，是一种竞争性的muscarinic acetylcholine receptorM1，M2，和M3拮抗剂，用于缓解尿道和膀胱疾病。 了解更多 -
Jaceosidin
Catalog No. A12080 Jaceosidin是一种来源于艾蒿的药理活性黄酮，通过阻断培养的人乳腺上皮细胞中erk-1和-2的磷酸化来抑制佛波酯诱导的cox-2和MMP-9的上调。 了解更多 -
LY2811376
Catalog No. A11776 -
Acemetacin (Emflex)
Catalog No. A11692 -
Semagacestat (LY450139)
Catalog No. A10836 Gamma-secretase 抑制剂Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。 了解更多 -
Nefiracetam (Translon)
Catalog No. A10631 Nefiracetam (Translon)是认知增强剂。它激活L/N型钙通道，胆碱能，单胺能和GABA能系统。 了解更多 -
BMS-708163 (Avagacestat)
Catalog No. A10157 Gamma-secretase 抑制剂BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。 了解更多
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