“Tutalthromycin second gen”的搜索结果
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Androgen Receptor Modulators
Ostarine (MK-2866,GTX-024)是一种雄激素受体调节剂(SARM)。
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Androgen receptor 拮抗剂
MDV3100(Enzalutamide)是一种androgen-receptor (AR)拮抗剂。在AR研究中强烈推荐的抑制剂。
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- Shiv Verma, .et al. Increased cytokine gene expression and cognition risk associated with androgen deprivation therapy, Prostate, 2022, Oct;82(14):1389-1399 PMID: 35821621
- Mi Chen, .et al. TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation, EMBO Rep, 2022, Aug 3;23(8):e53468 PMID: 35785414
- Prem P Kushwaha, .et al. Role of solute carrier transporters SLC25A17 and SLC27A6 in acquired resistance to enzalutamide in castration-resistant prostate cancer, Mol Carcinog, 2021, Dec 22 PMID: 34939235
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Dehydrogenase 抑制剂
Ammonium Glycyrrhizinate是来自Licorice root的一种独特产品，具有极高的甜味。
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Antioxidant, antiangiogenic, antitumor agent
(-)-Epigallocatechin gallate是一种从绿茶中分离出来的强效抗氧化剂多酚类黄酮。
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- Wafa Dridi, .et al. Influence of polysaccharide concentration on polyphenol-polysaccharide interactions, Carbohydr Polym, 2021, 274:118670 PMID: 34702486
- A S D'Costa, .et al. Inhibition of starch digestion by flavonoids: Role of flavonoid-amylase binding kinetics, Food Chem, 2020, Oct 1;341(Pt 2):128256 PMID: 33035827
- Fenteany G, .et al. Multilevel structure-activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism, Sci Rep, 2019, Sep 5;9(1):12801 PMID: 31488855
- LiliSun, .et al. Comparative Effect of Black, Green, Oolong and White Tea Intake on Body Weight Gain and Bile Acid Metabolism, Nutrition, 2019, pii:S0899-9007(18)31140-7
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Androgen Receptor 拮抗剂
(R)-Bicalutamide是一种活性的竞争性非甾体雄激素受体拮抗剂，对MDA 453细胞的IC50为0.17μM。
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COX-1 抑制剂
Ibuprofen (Advil)是一种非甾体抗炎药(NSAID)，靶向COX-1，IC50为13 μM。
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- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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Anti-Diabetic Agent
Acarbose是一种肠道alpha-glucosidase抑制剂，用于治疗2型糖尿病以及某些国家的前驱糖尿病。
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Androgen Receptor 拮抗剂
Bicalutamide (Casodex)是一种口服非甾体抗雄激素，用于治疗前列腺癌和多毛症。
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- Mi Chen, .et al. TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation, EMBO Rep, 2022, Aug 3;23(8):e53468 PMID: 35785414
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Anowara Khatun, .et al. Transcriptional Repression and Protein Degradation of the Ca2+-Activated K+ Channel KCa1.1 by Androgen Receptor Inhibition in Human Breast Cancer Cells, Front Physiol, 2018, 9: 312 PMID: 29713287
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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DNA Methyltransferase 抑制剂
Decitabine是一种次甲基化剂，它通过抑制DNA甲基转移酶来使DNA次甲基化。
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- Borbala Szabo, .et al. Aspirin mediates its antitumoral effect through inhibiting PTTG1 in pituitary adenoma, J Clin Endocrinol Metab, 2022, Sep 5;dgac496 PMID: 36059148
- Sangni Qian, .et al. Hypermethylation of tumor suppressor lncRNA MEF2C-AS1 frequently happened in patients at all stages of colorectal carcinogenesis, Clin Epigenetics, 2022, Sep 5;14(1):111 PMID: 36064442
- Borb??la Szab??, .et al. Demethylation status of somatic DNA extracted from pituitary neuroendocrine tumors indicates proliferative behavior, J Clin Endocrinol Metab, 2020, Jun 1;105(6):dgaa156 PMID: 32232382
- Bracha Shraibman, .et al. Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy, Mol Cell Proteomics, 2016, Sep; 15(9): 3058-3070 PMID: 27412690
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Estrogen/progestogen Receptor 激动剂
Hexestrol是一种致癌的合成雌激素，可抑制微管聚合和带状结构的形成。它是脂质过氧化的抑制剂。
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Androgen Receptor 激动剂
Andarine (GTX-007)是研究性的选择性雄激素受体调节剂（SARM）。
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NLRP3 inflammasome 抑制剂
Isoliquiritigenin是从光果甘草根中分到的黄酮类化合物，具有抗肿瘤的活性。目前正处于试验阶段，用于癌症和可卡因成瘾的辅助治疗的研究。
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Naringenin是一种黄烷酮，是一种类黄酮，被认为具有抗氧化剂，自由基清除剂，消炎，碳水化合物代谢促进剂和免疫系统调节剂等对人体健康的生物活性。
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Androgen Receptor 拮抗剂
Cyproterone acetate是17-羟孕酮的合成衍生物，可作为雄激素受体拮抗剂以及具有弱孕激素和糖皮质激素活性的弱孕激素受体激动剂。
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Apoptotic, antiproliferative and antiangiogenic agent
2-Methoxyestradiol是一种凋亡，抗增殖和抗血管生成剂。通过两种途径诱导p53诱导的细胞凋亡：p38和NF-κB的激活；和激活JNK和AP-1导致Bcl-2磷酸化。
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Protein kinase 抑制剂
Apigenin是中央苯并二氮杂central受体的配体，其Ki为4μM竞争性抑制氟硝西epa的结合，发挥抗焦虑和轻微的镇静作用。
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Anti-inflammatory agent
Asiatic acid常用于伤口愈合。亚洲酸具有抗氧化，抗炎和神经保护的特性。积雪草酸衍生物的合成可用作抗癌剂；糖原磷酸化酶抑制剂；保肝剂。
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- Rakhi Mishra, .et al. Comparative study of High-performance thin-layer chromatography and Antioxidant potential of Hydrocotyle asiatica mother tincture used in Homoeopathy, Indian J Res Homoeopathy, 2022, Sep 27
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Lipoxygenase 抑制剂
Baicalein是一种类黄酮，最初从黄cut的根中分离出来。Baicalein抑制脂质过氧化 (通过TBARS的产生评估)，IC50值为5 ?M。
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Bergenin (Cuscutin)是从各种药用植物中分离得到的异香豆素。 表现出温和的抗HIV活性，抗肝毒性活性和抗溃疡活性。
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- Barai P, .et al. Neuroprotective effects of bergenin in Alzheimer's disease: Investigation through molecular docking, in vitro and in vivo studies, Behav Brain Res, 2019, Jan 1;356:18-40 PMID: 30118774
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Biochanin A (4-Methylgenistein)是一种抗增殖和抗炎剂，可抑制iNOS的表达和脂多糖（LPS）诱导的巨噬细胞中一氧化氮的产生。此外，Biochanin A还具有阻断IκBα和p38 MAPK磷酸化的能力，从而阻止了NF-κB的活化。此外，已观察到生物chanin A抑制IL-6，IL-1β和TNF-α的产生。
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Chlorogenic acid是木质素生物合成的重要中间体。长期以来被称为抗氧化剂的这种化合物还可以减缓餐后葡萄糖向血液中的释放。
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- Feilin Dong, .et al. Chlorogenic Acid Alleviates Allergic Inflammatory Responses Through Regulating Th1/Th2 Balance in Ovalbumin-Induced Allergic Rhinitis Mice, Med Sci Monit, 2020, 26: e923358-1?Ce923358-10 PMID: 32868754
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Naringin (Naringoside)是一种黄酮苷，是葡萄柚中的主要的类黄酮，具有柚子汁的苦味。具有抗氧化，降血脂，抗肿瘤活性，并且对cytochrome P450有抑制作用。
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Free radical trapping agent
NXY-059是具有自由基捕获特性的神经保护性自旋捕集器苯基丁腈或“ PBN”的二磺酰基衍生物。它大大减轻了灵长类动物脑缺血引起的功能障碍。
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Oleanolic acid (Caryophyllin)是一种天然存在的三萜类，广泛分布于食品和药用植物中，与桦木酸有关。它是相对无毒。抗肿瘤和保肝的，并且具有抗病毒特性。
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Phloretin (Dihydronaringenin)是通过SGLT1和SGLT2抑制葡萄糖向细胞内的主动转运，尽管这种抑制作用比其糖苷phlorizin弱。
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- Subramaniam M, .et al. Comparison of Intestinal Glucose Flux and Electrogenic Current Demonstrates Two Absorptive Pathways in Pig and One in Nile Tilapia and Rainbow Trout, Am J Physiol Regul Integr Comp Physiol, 2019, Nov 20 PMID: 31746628
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Xanthone (Genicide)是一种有机化合物。可以通过加热水杨酸苯酯来制备。1939年，黄酮作为杀虫剂被引入，它目前被用作杀虫剂，用于杀虫蛾卵和杀幼虫剂。 黄原酮也用于制备黄原酸，其用于测定血液中的尿素水平。
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Antibacterial agent
Retapamulin (SB-275833)是一种抗菌剂，特别是蛋白质合成抑制剂。
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- Merianne Mohamad, .et al. Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci, Nucleic Acids Res, 2022, Feb 28;50(4):2128-2142 PMID: 35137182
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Protective agent
Dimesna (BNP7787)是一种用于减少尿毒症的尿道保护剂。
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Steroid sapogenin
Diosgenin是孕激素半合成的前体，又被用于早期联合口服避孕药中，是酸，强碱或皂苷酶水解的产物，是从薯os的块茎中提取的。
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- Rashmi Rawat, .et al. Effect of soaking conditions in the reduction of antinutritional factors in sunnhemp (Crotalaria juncea) seeds, Food Chemistry Advances, 2022, 1: 100092
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Vascular Disrupting Agent (VDA)
DMXAA (ASA404,Vadimezan)是一种肿瘤血管破坏剂（tumor-VDA），也是一种DT-diaphorase的竞争性抑制剂。
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- Zhang X, .et al. Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist, ACS Infect Dis, 2019, May 14 PMID: 31060350
- Bowei Liu, .et al. A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists, Antiviral Res, 2017, Nov; 147: 37-46 PMID: 28982551
- Fang Guo, .et al. Activation of Stimulator of Interferon Genes in Hepatocytes Suppresses the Replication of Hepatitis B Virus, Antimicrob Agents Chemother, 2017, Oct; 61(10): e00771-17 PMID: 28717041
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Genistin (Genistoside)是一种异黄酮，存在于许多饮食植物中，如大豆和葛根。显示出刺激体内雌激素依赖性乳腺癌细胞生长。
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- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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dehydrogenase inhibitor
Gossypol是一种多酚醛，渗透细胞并作为几种脱氢酶的抑制剂。
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- Amy L. Farthing, .et al. Response of northern bobwhites fed single doses of gossypol, Wildlife Society Bulletin, 2018, 42(3):460-466;
- Jin Qu, .et al. Gossypol potentiates carboplatin effects against ovarian cancer, Biomed Res, 2017, 28 (8): 3355-3361
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Antiangiogenic and Antitumor Agent
Honokiol是存在于广玉兰的球果、树皮和叶子中的木脂素，在黑色素瘤、肉瘤、骨髓瘤、白血病、膀胱、肺、前列腺、口腔鳞状细胞癌和结肠癌细胞系中显示促凋亡作用。
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Dehydrogenase 抑制剂
Leflunomide是一种嘧啶合成抑制剂，属于DMARD类药物。来氟米特用于缓解类风湿性关节炎引起的症状，如炎症、肿胀、僵硬和关节痛。
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(+)-Clopidogrel hydrogen sulfate (Plavix)是一种口服的，噻吩吡啶类抗血小板药物。
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Procollagen C-proteinase 抑制剂
UK-383367是一种前胶原C蛋白酶抑制剂，IC50为44 nM，对MMP具有优异的选择性。
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Hydrogen peroxide 抑制剂
Acetanilide在过氧化氢中用作抑制剂，并用于稳定纤维素酯清漆。
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Antilipolytic agent
Acipimox是用作降血脂药的烟酸衍生物。
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- A. Geneste, .et al. Adipocyte-conditioned medium induces resistance of breast cancer cells to lapatinib, BMC Pharmacol Toxicol, 2020, 21: 61 PMID: 32795383
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Genipin是garden子果实提取物中的一种化学化合物。Genipin是用于蛋白质，胶原蛋白，明胶和壳聚糖交联的出色天然交联剂。此外，京尼平可用作药物递送的调节剂，garden子蓝色颜料制备的原料以及生物碱合成的中间体。体外实验表明，Genipin阻断了酶解偶联蛋白2的作用。
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Crystal violet是三芳基甲烷染料。该染料被用作组织学染色剂，并被用于革兰氏菌的分类方法。
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Dehydrogenase 抑制剂
CPI-613是合成的α-硫辛酸硫辛酸类似物的对映异构体的外消旋混合物，具有潜在的化学预防和抗肿瘤活性。
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- Takuji Sakuratani, .et al. Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway, Virchows Arch, 2020, Aug 13 PMID: 32789692
- Egawa Y, .et al. Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma, PLoS One, 2018, Jun 7;13(6):e0198940 PMID: 29879220
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Estrogen receptor 拮抗剂
Tamoxifen Citrate是哺乳动物甾醇异构酶的选择性和有效抑制剂。
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- Renu Sudhakar, .et al. Bazedoxifene, a Postmenopausal Drug, Acts as an Antimalarial and Inhibits Hemozoin Formation, Microbiol Spectr, 2022, Jun 29;10(3) PMID: 35616371
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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Androgen Receptor 抑制剂
Apalutamide (ARN-509)是一种具有潜在抗肿瘤活性的雄激素受体拮抗剂，IC50 为 16 nM。ARN-509与靶组织中的AR结合，从而阻止了雄激素诱导的受体激活，并促进了无法转运至细胞核的无活性复合物的形成。这防止了AR应答基因的结合和转录。
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- Frédérique Mittler, .et al. High-Content Monitoring of Drug Effects in a 3D Spheroid Model, Front Oncol, 2017, 7: 293 PMID: 29322028
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Androgen 拮抗剂
17 alpha-propionate是一种新型的局部和外周选择性雄激素拮抗剂。
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Geniposide是一种具有各种生物活性，包括神经保护，抗糖尿病，抗增殖和抗氧化活性的环烯醚配糖苷。
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Isoconazole nitrate (Travogen)是一种唑类抗真菌剂。
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Resibufogenin是一种特异性na+/k+-ATP酶抑制剂。
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Gentamycin sulfate (Gentacycol)是一种氨基糖苷类抗生素，从小单孢菌属中分离得到。
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Dihydroorotate Dehydrogenase 抑制剂
Brequinar是二氢乳清酸脱氢酶的抑制剂，二氢乳清酸脱氢酶是从头进行嘧啶生物合成的酶。
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oxazolidinone antibacterial agent
Tedizolid (TR-701)是一种新型的恶唑烷酮抗菌剂。
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