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Dorzagliatin
Catalog No. A22297 GK activatorDorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes. 了解更多 -
Ribociclib hydrochloride
Catalog No. A22303 CDK4/6 inhibitorRibociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, 了解更多 -
BDTX-189
Catalog No. A22306 Anticancer agentBDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity. 了解更多 -
LDN-193189 2HCl
Catalog No. A22307 BMP signaling inhibitorLDN193189 HCl (DM-3189) is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cell lines, respectively, 200-fold selectivity for BMP versus TGF-β. 了解更多 -
Ferulic acid sodium
Catalog No. A22310 FGFR1 inhibitorFerulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively. 了解更多 -
Remibrutinib
Catalog No. A22322 BTK inhibitorRemibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. 了解更多 -
Benzamidine hydrochloride
Catalog No. A22323 trypsin-like serine proteases inhibitorBenzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 ?M, 21 ?M, 20 ?M and 110 ?M for uPA, trypsin, tryptase and factor Xa, respectively. 了解更多 -
Ehp inhibitor 2
Catalog No. A22325 Eph family tyrosine kinase inhibitorEhp inhibitor 2 is a Eph family tyrosine kinase inhibitor. 了解更多 -
Mobocertinib
Catalog No. A22334 inhibitor of EGFR and HER2 oncogenic mutantsMobocertinib (TAK-788) is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity. 了解更多 -
3'-Hydroxypterostilbene
Catalog No. A22341 natural pterostilbene analogue3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 了解更多 -
JNJ-38158471
Catalog No. A22345 VEGFR-2 inhibitorJNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively. 了解更多 -
CCG-222740
Catalog No. A22348 MRTF pathway inhibitorCCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. 了解更多 -
7,4'-Di-O-methylapigenin
Catalog No. A22349 antifungalThe compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines. 了解更多 -
Timosaponin AIII
Catalog No. A22353 Inhibitor of U46619-induced Rat Platelet AggregationTimosaponin AIII is a potent Inhibitor of U46619-induced Rat Platelet Aggregation, Selectively Inhibiting TxA2-induced Platelet Activation, Preferably Suppressing TP-mediated Activation of Gq, not G12/13, Signaling Pathways. 了解更多 -
(2S,3R,4S)-4-Hydroxyisoleucine
Catalog No. A22356 anti-diabetes agent(2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from Trigonella foenum-graecum, with anti-diabetes and anti-diabetic nephropathy activity. 了解更多 -
Solamargine
Catalog No. A22357 anticancer agentSolamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. 了解更多 -
5-Bromoindole
Catalog No. A22363 inhibitor of glycogen synthase kinase 35-bromoindole is an important pharmaceutical chemical intermediate and a potential inhibitor of glycogen synthase kinase 3 (GSK-3). 了解更多 -
Emedastine
Catalog No. A22158 histamine H1 receptor antagonistEmedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. 了解更多 -
IACS-13909
Catalog No. A22159 SHP2 allosteric inhibitorIACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. 了解更多 -
ATR inhibitor 2
Catalog No. A22162 ATR inhibitorATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. 了解更多 -
Molnupiravir
Catalog No. A22165 broad-spectrum antiviral activityMolnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19. 了解更多 -
Gentiopicroside
Catalog No. A22172 antianti-inflammatoryand antioxidative effectsGentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 ?M and 22.8 ?M for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects. 了解更多 -
Periplogenin
Catalog No. A22174 anti-psoriatic agentPeriplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots, with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation. 了解更多 -
NSC23005 free acid
Catalog No. A22180 p18INK inhibitorNSC23005 is a p18INK inhibitor. NSC23005 potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). 了解更多 -
OTSSP167 hydrochloride
Catalog No. A22184 MELK inhibitorOTSSP167 (hydrochloride) is a highly potent MELK inhibitor with IC50 value of 0.41 nM. 了解更多 -
BIO-013077-01
Catalog No. A22185 antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4BIO-013077-01, Novel potent antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4. 了解更多
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