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Paprotrain
Catalog No. A20346 MKLP-2 inhibitorPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM. 了解更多 -
Masupirdine free base
Catalog No. A20245 5-HT6 receptor antagonistMasupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). 了解更多 -
Talazoparib tosylate
Catalog No. A20238 PARP1/2 inhibitorTalazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC50 of 0.57 nM for PARP1. 了解更多 -
Dot1L-IN-2
Catalog No. A20231 Dot1L inhibitorDot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively. 了解更多 -
SSTR5 antagonist 1
Catalog No. A20218 SSTR5 antagonistSSTR5 antagonist 1 is a potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonist with IC50s of 9.6 and 57 nM for hSSTR5 and mSSTR5, respectively. (Compound 25a). 了解更多 -
Palmitodiolein
Catalog No. A20217 Palmitodiolein (Triglyceride POO) is a triacylglycerol which is present in vegetable oils. 了解更多 -
(S,R,S)-AHPC-PEG6-C4-Cl
Catalog No. A20169 (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. 了解更多 -
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl
Catalog No. A20157 (S,R,S)-AHPC-(C3-?PEG)?2-?C6-?Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3-?PEG)?2-?C6-?Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. 了解更多 -
RIP1 kinase inhibitor 1
Catalog No. A20154 RIP1 kinase inhibitorRIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04). 了解更多 -
GRK2-IN-1
Catalog No. A20131 GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM). GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine. 了解更多 -
IDH1 Inhibitor 1
Catalog No. A20065 IDH1 inhibitorIDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT, respectively. Anticancer activity. 了解更多 -
PI3K/mTOR Inhibitor-1
Catalog No. A20055 PI3K/mTOR inhibitorPI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual PI3K/mTOR inhibitor with IC50s of 20/376/204/46 nM and 186 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ and mTOR, respectively. Antitumor activity. 了解更多 -
P-gp modulator 1
Catalog No. A20054 Pgp modulatorP-gp modulator 1 is a high affinity, orally available modulator of P-glycoprotein (Pgp), can reverse the Pgp-mediated multidrug resistance ((MDR). 了解更多 -
CDK8/19-IN-1
Catalog No. A19986 CDK8/19 dual inhibitorCDK8/19-IN-1 is a potent, selective and oral bioavailable CDK8/19 dual inhibitor, with IC50s of 0.46 nM, 0.99 nM and 270 nM for CDK8, CDK19 and CDK9, respectively. 了解更多 -
Diethylamino hydroxybenzoyl hexyl benzoate
Catalog No. A19968 photostable UV-A absorberDiethylamino hydroxybenzoyl hexyl benzoate is a photostable UV-A absorber. 了解更多 -
PF 03709270
Catalog No. A19948 PF 03709270 is an orally available ester prodrug form of sulopenem, with broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria. 了解更多 -
STING agonist-3
Catalog No. A19882 STING agonistSTING agonist-3, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. 了解更多 -
(±)-CPSI-1306
Catalog No. A19875 MIF antagonist(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF). 了解更多 -
BAY-1816032
Catalog No. A19868 BUB1 kinase inhibitorBAY-1816032 is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM. 了解更多 -
GSK3395879
Catalog No. A19861 TRPV4 antagonistGSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC50 of 1 nM for hTRPV4. 了解更多 -
L-368,899 hydrochloride
Catalog No. A19843 oxytocin receptor antagonistL-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent. 了解更多 -
Acridine Orange hydrochloride
Catalog No. A19835 fluorescent dyeAcridine Orange hydrochloride is a cell-permeable fluorescent dye that binds to nucleic acids, resulting in an altered spectral emission. 了解更多 -
D-Lin-MC3-DMA
Catalog No. A19797 siRNA delivery vehicleD-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle. 了解更多 -
GSK3004774
Catalog No. A19779 CaSR agonistGSK3004774 is a potent, nonabsorbable agonist of CaSR, with an pEC50 of 7.3, 6.6 and 6.5 for human, mouse and rat CaSR, respectively. GSK3004774 shows an EC50 of 50 nM for human CaSR. 了解更多 -
Dabsyl chloride
Catalog No. A19755 amine derivatizing agentDabsyl chloride is an amine derivatizing agent, able to give rise to stable products that can be easily monitored spectrophotometrically at 460 nm; Dabsyl chloride also used for labeling amino acids. 了解更多 -
INCB-057643
Catalog No. A19737 -
4-Octyl Itaconate
Catalog No. A19731 4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. 了解更多 -
Seclidemstat
Catalog No. A19730 LSD1 inhibitorSeclidemstat (SP-2577) is a potent and orally bioavailable LSD1 inhibitor, with a mean IC50 of 127 nM. 了解更多
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