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Masupirdine free base
Catalog No. A20245 5-HT6 receptor antagonistMasupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). 了解更多 -
Talazoparib tosylate
Catalog No. A20238 PARP1/2 inhibitorTalazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC50 of 0.57 nM for PARP1. 了解更多 -
Dot1L-IN-2
Catalog No. A20231 Dot1L inhibitorDot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively. 了解更多 -
SSTR5 antagonist 1
Catalog No. A20218 SSTR5 antagonistSSTR5 antagonist 1 is a potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonist with IC50s of 9.6 and 57 nM for hSSTR5 and mSSTR5, respectively. (Compound 25a). 了解更多 -
Palmitodiolein
Catalog No. A20217 Palmitodiolein (Triglyceride POO) is a triacylglycerol which is present in vegetable oils. 了解更多 -
Oxythiamine
Catalog No. A20210 vitamin B1 antagonistOxythiamine, an antimetabolite and a vitamin B1 antagonist, is a well-known thiamine antagonist and inhibitor of transketolase. 了解更多 -
(S,R,S)-AHPC-PEG6-C4-Cl
Catalog No. A20169 (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. 了解更多 -
Polymyxin B nonapeptide
Catalog No. A20168 Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes. 了解更多 -
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl
Catalog No. A20157 (S,R,S)-AHPC-(C3-?PEG)?2-?C6-?Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3-?PEG)?2-?C6-?Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. 了解更多 -
RIP1 kinase inhibitor 1
Catalog No. A20154 RIP1 kinase inhibitorRIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04). 了解更多 -
GRK2-IN-1
Catalog No. A20131 GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM). GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine. 了解更多 -
N-Deshydroxyethyl Dasatinib
Catalog No. A20125 N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL. 了解更多 -
5α-Pregnane-3β,6α-diol-20-one
Catalog No. A20118 5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells. 了解更多 -
Gemcabene
Catalog No. A20083 -
IDH1 Inhibitor 1
Catalog No. A20065 IDH1 inhibitorIDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT, respectively. Anticancer activity. 了解更多 -
PI3K/mTOR Inhibitor-1
Catalog No. A20055 PI3K/mTOR inhibitorPI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual PI3K/mTOR inhibitor with IC50s of 20/376/204/46 nM and 186 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ and mTOR, respectively. Antitumor activity. 了解更多 -
P-gp modulator 1
Catalog No. A20054 Pgp modulatorP-gp modulator 1 is a high affinity, orally available modulator of P-glycoprotein (Pgp), can reverse the Pgp-mediated multidrug resistance ((MDR). 了解更多 -
RO 4938581
Catalog No. A20022 GABAA α5 inverse agonistRO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively). 了解更多 -
D4-abiraterone
Catalog No. A19987 androgen receptor antagonistD4-abiraterone is a major metabolite of abiraterone. D4-abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor. 了解更多 -
CDK8/19-IN-1
Catalog No. A19986 CDK8/19 dual inhibitorCDK8/19-IN-1 is a potent, selective and oral bioavailable CDK8/19 dual inhibitor, with IC50s of 0.46 nM, 0.99 nM and 270 nM for CDK8, CDK19 and CDK9, respectively. 了解更多 -
Diethylamino hydroxybenzoyl hexyl benzoate
Catalog No. A19968 photostable UV-A absorberDiethylamino hydroxybenzoyl hexyl benzoate is a photostable UV-A absorber. 了解更多 -
S-methyl-KE-298
Catalog No. A19954 S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. 了解更多 -
PF 03709270
Catalog No. A19948 PF 03709270 is an orally available ester prodrug form of sulopenem, with broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria. 了解更多 -
3',4'-Dihydroxyflavonol
Catalog No. A19946 3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant, which reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries. 了解更多 -
N-Acetylhistamine
Catalog No. A19942 N-Acetylhistamine is a histamine metabolite. N-acetylhistamine can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions. 了解更多 -
Ramelteon metabolite M-II
Catalog No. A19921 melatonin agonistRamelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist. 了解更多 -
Leelamine hydrochloride
Catalog No. A19910 CB1 agonistLeelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. 了解更多 -
STING agonist-3
Catalog No. A19882 STING agonistSTING agonist-3, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. 了解更多 -
(±)-CPSI-1306
Catalog No. A19875 MIF antagonist(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF). 了解更多 -
BAY-1816032
Catalog No. A19868 BUB1 kinase inhibitorBAY-1816032 is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM. 了解更多 -
GSK3395879
Catalog No. A19861 TRPV4 antagonistGSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC50 of 1 nM for hTRPV4. 了解更多 -
L-368,899 hydrochloride
Catalog No. A19843 oxytocin receptor antagonistL-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent. 了解更多 -
Acridine Orange hydrochloride
Catalog No. A19835 fluorescent dyeAcridine Orange hydrochloride is a cell-permeable fluorescent dye that binds to nucleic acids, resulting in an altered spectral emission. 了解更多
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