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搜索结果：“Ligand-gated Ion Channels”

“Ligand-gated Ion Channels”的搜索结果

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ICA-121431

Catalog No. A13773
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NaV1.3 and NaV1.1 channels 抑制剂

ICA-121431是人NaV1.3和NaV1.1通道的有效和选择性抑制剂（IC50值分别为13和23 nM）。了解更多

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Cucurbitacin B

Catalog No. A14665
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Microtubule polymerization 抑制剂

Cucurbitacin B是一种天然的三萜类化合物，以其强大的抗癌活性而闻名，研究表明该化合物抑制JAK/STAT3途径。也是一种有效的微管聚合抑制剂。了解更多

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PD 0332991 Isethionate

Catalog No. A13811
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CDK4/6 抑制剂

PD 0332991 Isethionate是CDK4/6的高选择性抑制剂，IC50分别为11 nM/16 nM。了解更多

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- K Keegan ,etc. Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. Molecular cancer therapeutics, 2014, 13(4), 880-889.
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Apilimod

Catalog No. A13794
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IL-12/IL-23 inhibitor

Apilimod is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS?Cstimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. 了解更多

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Caffeic Acid Phenethyl Ester

Catalog No. A13698
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NF-κB activation 抑制剂

Caffeic Acid Phenethyl Ester是一种有效且特异性的NF-κB活化抑制剂。了解更多

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4E1RCat

Catalog No. A14301
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eIF4F subunit interaction 抑制剂

4E1RCat是eIF4E：eIF4G和eIF4E：4E-BP1相互作用的双重抑制剂。了解更多

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JSH 23

Catalog No. A14142
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NF-κB 抑制剂

JSH 23是NF-kB的抑制剂，可阻止其转运入细胞核（IC50 = 7.1 uM）。了解更多

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- Yu N, .et al. Low-Dose Radiation Promotes Dendritic Cell Migration and IL-12 Production via the ATM/NF-KappaB Pathway, Radiat Res, 2018, Apr;189(4):409-417 PMID: 29420126
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Kobe0065

Catalog No. A13135
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Ras-Raf interaction 抑制剂

Kobe0065抑制锚定依赖性和非依赖性生长，阻断MEK / ERK活性并诱导H-rasG12V转化的NIH3T3细胞凋亡。了解更多

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AZD-9291 (Osimertinib)

Catalog No. A13681
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EGFR 抑制剂

AZD-9291 (Osimertinib)是第三代EGFR抑制剂，在临床前研究中显示出希望，并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。了解更多

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- Liu YN, .et al. Acquired resistance to EGFR tyrosine kinase inhibitors is mediated by the reactivation of STC2/JUN/AXL signaling in lung cancer, Int J Cancer, 2019, Jun 4 PMID: 31162839
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Salubrinal

Catalog No. A12676
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eIF2α dephosphorylation 抑制剂

Salubrinal是细胞磷酸酶复合物的可渗透细胞的选择性抑制剂，可将真核翻译起始因子2亚基α（eIF2α）磷酸化。保护细胞免受内质网应激诱导的细胞凋亡（EC50?15 μM）。了解更多

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- Gregory R. Kardos, .et al. Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery, Front Oncol, 2020, 10: 834 PMID: 32637352
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NSC 23766

Catalog No. A12546
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Rac1 activation 抑制剂

SC 23766是Rac1-GEF相互作用的选择性抑制剂。通过Rac特异性鸟嘌呤核苷酸交换因子（GEF）TrioN和Tiam1（IC50为50 μM）阻止Rac1激活，而不影响Cdc42或RhoA激活。了解更多

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Zoledronic Acid

Catalog No. A11010
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osteoclastic bone resorption 抑制剂

Zoledronic acid, 破骨细胞抑制剂，通过抑制甲羟戊酸途径诱导破骨细胞凋亡。了解更多

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Brefeldin A

Catalog No. A11156
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Protein translocation 抑制剂

Brefeldin A阻断ADP-核糖基化因子与高尔基体的结合并抑制GDP-GTP交换。了解更多

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Baicalin

Catalog No. A10121
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HIV-1 production 抑制剂

Baicalin是已知的脯氨酰内肽酶抑制剂，并且影响GABA受体。了解更多

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- Shoichi Ozawa, .et al. Uremic serum residue decreases SN-38 sensitivity through suppression of organic anion transporter polypeptide 2B1 in LS-180 colon cancer cells, Sci Rep, 2019, 9: 15464

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