“Tutalthromycin second gen”的搜索结果

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  1. 4-Hydroxytamoxifen

    Catalog No. A20955
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    estrogen receptor modulator
    4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM). 了解更多
  2. Enclomiphene citrate

    Catalog No. A21830
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    oestrogen receptor antagonist
    Enclomiphene citrate is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property. 了解更多
  3. Nomegestrol acetate

    Catalog No. A21829
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    progesterone receptor agonist
    Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors. 了解更多
  4. AZD9496 maleate

    Catalog No. A21726
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    estrogen receptor (ERα) antagonist
    AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC50 of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD). 了解更多
  5. H3B-6545 Hydrochloride

    Catalog No. A21629
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    estrogen receptor covalent antagonist
    H3B-6545 Hydrochloride is an oral, selective estrogen receptor covalent antagonist (SERCA). 了解更多
  6. Pipendoxifene hydrochloride

    Catalog No. A21623
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    estrogen receptor modulators
    Pipendoxifene hydrochloride is a selective estrogen receptor modulators (SERMs). 了解更多
  7. Fulvestrant R enantiomer

    Catalog No. A21545
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    estrogen receptor antagonist
    Fulvestrant R enantiomer (ICI 182780 R enantiomer; ZD 9238 R enantiomer; ZM 182780 R enantiomer) is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. 了解更多
  8. GDC-0927 Racemate

    Catalog No. A21507
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    estrogen receptor degrader
    GDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. 了解更多
  9. Estetrol

    Catalog No. A21291
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    nuclear estrogen receptor modulator
    Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. 了解更多
  10. Tamoxifen

    Catalog No. A16738
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    selective estrogen receptor modulator (SERM)
    Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. 了解更多
  11. Elacestrant

    Catalog No. A12244
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    Estrogen receptor degrader
    Elacestrant (RAD1901) is an orally available selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. 了解更多
  12. MK-6913

    Catalog No. A12311
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    Estrogen receptor β agonist
    Tetrahydrofluoroene 52 is a potent and selective estrogen receptor β agonist. 了解更多
  13. PROTAC ER Degrader-3

    Catalog No. A18519
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    PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). 了解更多
  14. PROTAC ERRα Degrader-1

    Catalog No. A18910
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    ERRα Degrader
    PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多
  15. PROTAC ERRα ligand 2

    Catalog No. A18939
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    ERRα inverse agonist
    PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM). 了解更多
  16. H3B-6545

    Catalog No. A20100
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    Estrogen receptor antagonist
    H3B-6545 is an oral, selective estrogen receptor covalent antagonist (SERCA). 了解更多
  17. OP-3633

    Catalog No. A18468
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    Glucocorticoid Receptor Antagonist
    OP-3633 is a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (IC50 = 29 nM). 了解更多
  18. Beclometasone

    Catalog No. A18177
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    glucocorticoid receptor agonist
    Beclometasone, also known as Beclomethasone, is an anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma. 了解更多
  19. Lasofoxifene Tartrate

    Catalog No. A18097
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    selective Estrogen receptor modulator
    Lasofoxifene tartrate is a third-generation selective estrogen receptor modulator. 了解更多
  20. GW-870086

    Catalog No. A18343
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    Glucocorticoid receptor agonist
    GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC50 of 10.1 in A549 cells expressing NF-κB. 了解更多
  21. (R)-Equol

    Catalog No. A16986
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    Estrogen receptor 激动剂
    (R)-Equol是ER&alpha和ER&beta的激动剂,Kis分别为27.4和15.4 nM。 了解更多
  22. Desogestrel

    Catalog No. A16173
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    Desogestrel是一种合成的孕激素,通常用作联合口服避孕药的孕激素成分。 了解更多
  23. GDC-0810 (Brilanestrant)

    Catalog No. A15958
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    Estrogen receptor degrader
    GDC-0810 (Brilanestrant)是一种口服可生物利用的选择性雌激素受体降解剂(SERD),在耐他莫昔芬的乳腺癌异种移植物中表现出强大的活性。 了解更多
  24. Flutamide

    Catalog No. A10402
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    Androgen receptor 拮抗剂
    Flutamide是一种抗雄激素药物,其活性代谢洛丽塔与Ki值为55nM的雄激素受体结合,可作用于前列腺癌。 了解更多
  25. (E/Z)-4-hydroxy Tamoxifen

    Catalog No. A12532
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    Estrogen receptor 拮抗剂
    (E/Z)-4-hydroxy Tamoxifen是他莫昔芬的活性代谢产物,是一种选择性雌激素受体(ER)调节剂,广泛用于乳腺癌的治疗和化学预防治疗。 了解更多
  26. GSK-2881078

    Catalog No. A12645
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    androgen receptor modulator
    GSK-2881078是一种选择性雄激素受体调节剂(SARM),正在针对肌肉萎缩以改善其身体功能的受试者的肌肉生长和力量进行评估。 了解更多
  27. AZD9496

    Catalog No. A15822
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    estrogen receptor downregulator and 拮抗剂
    AZD9496是一种有效的生物选择性雌激素受体下调剂和拮抗剂。 了解更多
  28. EPI-001

    Catalog No. A15814
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    Androgen Receptor 拮抗剂
    EPI-001是雄激素受体(AR)的拮抗剂,它通过与AR的N末端结构域(NTD)共价结合并阻断AR及其剪接变体(转录因子IC50)的转录活性所需的蛋白质相互作用抑制AR NTD反式激活6μM) 了解更多
  29. ODM-201

    Catalog No. A15797
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    Androgen receptor 拮抗剂
    ODM-201是一种有效且完全的人类AR(hAR)拮抗剂,IC50值为26 nM。 了解更多
  30. Endoxifen

    Catalog No. A12639
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    Estrogen receptor 拮抗剂
    Endoxifen是他莫昔芬的次生代谢产物。它是负责他莫昔芬在ER阳性乳腺癌中有效性的主要代谢物。Endoxifen Z-isomer抑制hERG, 这种作用具有浓度依赖性, IC50值为1.6μM。 了解更多
  31. Toremifene

    Catalog No. A15265
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    Estrogen receptor modulator
    Toremifene是正在开发中的第二代选择性雌激素受体调节剂(SERM),用于预防骨质疏松症。 了解更多
  32. MK-0773

    Catalog No. A15164
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    Androgen receptor modulator
    MK-0773是一种选择性雄激素受体调节剂(SARMs),是一种4-氮杂-类固醇,在人体中表现出组织选择性(IC50 = 6.6 nM)。 了解更多
  33. Bazedoxifene

    Catalog No. A15019
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    Estrogen modulator
    Bazedoxifene是雌激素受体的第三代选择性调节剂。 了解更多
  34. Acetyl Angiotensinogen (1-14), porcine

    Catalog No. A14883
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    Acetyl Angiotensinogen (1-14), porcine血管紧张素原基因编码的蛋白质被称为血管紧张素原或血管紧张素原的前体。 了解更多
  35. N-desMethyl EnzalutaMide

    Catalog No. A13964
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    androgen-receptor (AR) 拮抗剂
    N-desMethyl EnzalutaMide用于治疗涉及雄激素,雌激素和孕激素受体的疾病。 了解更多
  36. Ospemifene

    Catalog No. A14261
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    estrogen receptor modulator
    Ospemifene是一种非激素选择性雌激素受体调节剂(SERM)。 了解更多
  37. BMS564929

    Catalog No. A12805
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    Androgen receptor (AR) modulator
    BMS-564929是一种新型,高效,口服活性,非甾体组织选择性雄激素受体(AR)调节剂,结合到雄激素受体,Ki 为 2.11±0.16 nM。该化合物已被推进临床试验,以治疗与年龄相关的功能衰退。 了解更多
  38. Acolbifene (EM 652, SCH57068)

    Catalog No. A12771
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    estrogen receptor modulator
    Acolbifene (EM 652,SCH57068)是第四代选择性的estrogen receptor拮抗剂,LC50 值为 22±3 nM。用于预防高乳腺癌女性的乳腺癌。 盐酸阿科比芬与体内雌激素受体结合,阻断雌激素对乳房的作用。 它是选择性雌激素受体调节剂(SERM)的一种。 了解更多
  39. Liquiritigenin

    Catalog No. A12083
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    Liquiritigenin是一种植物来源的高选择性雌激素受体β激动剂。 了解更多
  40. 17 alpha-propionate

    Catalog No. A10009
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    Androgen 拮抗剂
    17 alpha-propionate是一种新型的局部和外周选择性雄激素拮抗剂。 了解更多
  41. Tamoxifen Citrate

    Catalog No. A10885
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    Estrogen receptor 拮抗剂
    Tamoxifen Citrate是哺乳动物甾醇异构酶的选择性和有效抑制剂。 了解更多
  42. Cyproterone acetate

    Catalog No. A11409
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    Androgen Receptor 拮抗剂
    Cyproterone acetate是17-羟孕酮的合成衍生物,可作为雄激素受体拮抗剂以及具有弱孕激素和糖皮质激素活性的弱孕激素受体激动剂。 了解更多
  43. Andarine (GTX-007)

    Catalog No. A10076
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    Androgen Receptor 激动剂
    Andarine (GTX-007)是研究性的选择性雄激素受体调节剂(SARM)。 了解更多
  44. Hexestrol

    Catalog No. A10451
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    Estrogen/progestogen Receptor 激动剂
    Hexestrol是一种致癌的合成雌激素,可抑制微管聚合和带状结构的形成。它是脂质过氧化的抑制剂。 了解更多
  45. Bicalutamide (Casodex)

    Catalog No. A10142
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    Androgen Receptor 拮抗剂
    Bicalutamide (Casodex)是一种口服非甾体抗雄激素,用于治疗前列腺癌和多毛症。 了解更多
  46. (R)-Bicalutamide

    Catalog No. A10008
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    Androgen Receptor 拮抗剂
    (R)-Bicalutamide是一种活性的竞争性非甾体雄激素受体拮抗剂,对MDA 453细胞的IC50为0.17μM。 了解更多
  47. MDV3100

    Catalog No. A10562
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    Androgen receptor 拮抗剂
    MDV3100(Enzalutamide)是一种androgen-receptor (AR)拮抗剂。在AR研究中强烈推荐的抑制剂。 了解更多
  48. Ostarine (MK-2866, GTx-024)

    Catalog No. A10253
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    Androgen Receptor Modulators
    Ostarine (MK-2866,GTX-024)是一种雄激素受体调节剂(SARM)。 了解更多

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