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Pyrazofurin
Catalog No. A18601 OPRTase inhibitorPyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5'-phosphate (UMP) synthase[1]. Pyrazofurin is an active, sensitive orotate-phosphoribosyltransferase inhibitor with IC50s between 0.06-0.37 ?M in the three squamous cell carcinoma (SCC) cell lines Hep-2, HNSCC-14B and HNSCC-14C. 了解更多 -
PDE12-IN-3
Catalog No. A18579 PDE12 inhibitorPDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity. 了解更多 -
ACX-362E
Catalog No. A18560 DNA polymerase IIIC 抑制剂ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens. 了解更多 -
P300/CBP-IN-3
Catalog No. A18544 p300/CBP histone acetyltransferase inhibitorP300/CBP-IN-3, a p300/CBP histone acetyltransferase inhibitor. 了解更多 -
VP3.15
Catalog No. A18538 dual PDE7/GSK-3 inhibitorVP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多 -
Pseudouridimycin
Catalog No. A18520 RNA polymerase 抑制剂Pseudouridimycin (PUM), an antibiotic, is a selective bacterial RNA polymerase (RNAP) inhibitor. Pseudouridimycin is a C-nucleoside analogue that is effective against both Gram-negative and Gram-positive bacteria. 了解更多 -
DNA31
Catalog No. A18466 -
ZT-12-037-01
Catalog No. A18395 ATP-competitive STK19 inhibitorZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor. ZT-12-037-01 effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo. 了解更多 -
CL2A-SN-38
Catalog No. A18392 DNA Topoisomerase I inhibitorCL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. 了解更多 -
Galanthamine
Catalog No. A12483 AChE inhibitorGalanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM. 了解更多 -
PF-05085727
Catalog No. A20098 PDE2A inhibitorPF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM. 了解更多 -
GSK2973980A
Catalog No. A20060 DGAT1 inhibitorGSK2973980A is a potent and selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 3 nM. 了解更多 -
LSN 3213128
Catalog No. A19472 AICARFT inhibitorLSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity. 了解更多 -
GSK3368715
Catalog No. A19136 PRMT inhibitorGSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). 了解更多 -
KPT-6566
Catalog No. A19126 prolyl isomerase PIN1 inhibitorKPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640?nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity. 了解更多 -
Acetyllovastatin
Catalog No. A19111 AChE inhibitorAcetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC50 of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines. 了解更多 -
Tankyrase-IN-2
Catalog No. A19092 Tankyrase inhibitorTankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor (IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). 了解更多 -
TDP1 Inhibitor-1
Catalog No. A19072 TDP1 inhibitorTDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 7 μM. 了解更多 -
KRAS G12C inhibitor 13
Catalog No. A19041 KRAS G12C inhibitorKRAS G12C inhibitor 13 is a KRAS G12C inhibitor extracted from patent WO2018143315A1, compound 30. 了解更多 -
Eicosatetraynoic acid
Catalog No. A19008 COX/LOX inhibitorEicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 ?M?? 了解更多 -
KRAS G12C inhibitor 5
Catalog No. A18840 KRas G12C inhibitorKRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147. 了解更多 -
BuChE-IN-TM-10
Catalog No. A18693 BuChE inhibitorBuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. 了解更多 -
KRAS G12C inhibitor 15
Catalog No. A18447 KRAS G12C inhibitorKRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM. 了解更多 -
KRAS G12C inhibitor 16
Catalog No. A18444 KRAS G12C inhibitorKRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM. 了解更多 -
KRAS G12C inhibitor 17
Catalog No. A18441 KRAS G12C inhibitorKRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM. 了解更多 -
MAC glucuronide α-hydroxy lactone-linked SN-38
Catalog No. A18407 Topoisomerase I inhibitorMAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. 了解更多 -
MAC glucuronide phenol-linked SN-38
Catalog No. A18403 DNA topoisomerase I inhibitorMAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively. 了解更多 -
Top1 inhibitor 1
Catalog No. A13304 human topoisomerase I (Top1) inhibitorTop1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM. 了解更多 -
Entacapone
Catalog No. A10355 COMT inhibitorEntacapone is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment. 了解更多 -
KRas G12C inhibitor 1
Catalog No. A13152 Kras-G12C inhibitor 1KRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1. 了解更多 -
KRas G12C inhibitor 2
Catalog No. A13064 Kras-G12C inhibitorKRas G12C inhibitor 2 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1. 了解更多 -
KRas G12C inhibitor 3
Catalog No. A13018 Kras-G12C inhibitorKRas G12C inhibitor 3 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1. 了解更多 -
PF-06471553
Catalog No. A12640 MGAT3 inhibitorPF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM. 了解更多
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