GW3965 HCl是一种选择性的口服活性肝X受体（LXR）完全激动剂。 了解更多

BRL 52537 hydrochloride是一种高度选择性和有效的κ阿片类激动剂（Ki = 0.24 nM）。比吗啡强25倍。 了解更多

Ondansetron HCl (GR 38032F)是5-羟色胺5-HT3受体拮抗剂，主要用作止吐药，通常在化疗后用于治疗恶心和呕吐。 了解更多

Olanzapine (LY170053)对5-HT2血清素和D2多巴胺受体拮抗剂具有高亲和力。 了解更多

VU 0361737是mGluR-4的选择性正变构调节剂（人和大鼠受体的EC50值分别为240和110 nM）。 了解更多

2-Hydroxysaclofen对GABAB受体是一种有效的选择性拮抗剂。 了解更多

CVT-6883是一种选择性的A2B腺苷拮抗剂，代表了一种治疗心肺疾病的新型潜在方法。 了解更多

NVP-AAM077抑制成年小鼠在脑室下区域和齿状回中的祖细胞增殖，并降低了齿状回中的新生细胞的存活。 了解更多

Labetalol HCl是选择性α1-肾上腺素能受体和非选择性β-肾上腺素能受体的双重拮抗剂。 了解更多

BRL 37344 Na Salt是具有脂解活性的β3-AR（β3-肾上腺素能受体）选择性激动剂。 了解更多

Cimaterol是β的有效激动剂；肾上腺素能受体(人β的pEC50 = 8.13、8.78和6.62；1β，2β和3β)。 了解更多

SB-505124 Hydrochloride是激活素受体样激酶（ALKS）的抑制剂。 了解更多

CIQ是包含NR2C或NR2D亚基的NMDA受体的亚基选择性增强剂。 了解更多

Imidafenacin是一种有效的选择性M3受体抑制剂，Kb为0.317 nM。对M2受体的效力较低（IC50 = 4.13 nM）。 了解更多

RO 25-6981 maleate是含有NR2B亚基的NMDA受体的强效和选择性活性依赖性阻断剂。克隆的受体亚基组合NR1C/NR2B和NR1C/NR2A的IC50值分别为0.009和52 uM。 了解更多

VU 0364770是mGlu4受体的正变构调节剂，在表达mGlu4的HEK 293细胞中EC50值为290 nM。 了解更多

Acebutolol HCl是一种β-肾上腺素能受体拮抗剂，用于治疗高血压，心绞痛和心律不齐。 了解更多

Ro 25-6981是N-甲基-D-天冬氨酸（NMDA）受体的高亲和力，强效选择性阻断剂。 了解更多

Proxyphylline是茶碱的衍生物，由于其心血管特性而被用作支气管扩张剂。它与A2腺苷受体（对于血小板，Ki = 850μM）选择性拮抗A1腺苷受体（对于牛脑，Ki = 82 nM）。 了解更多

Cenicriviroc(TAK-652,TBR-652)是CCR2和CCR5受体的抑制剂，可使其充当防止病毒进入人细胞的进入抑制剂 了解更多

S38093 HCl是组胺H3受体的反向激动剂。 了解更多

Afloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site. 了解更多

Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5. 了解更多

Picrotoxinin negatively modulate the action of GABA on GABAA receptors. 了解更多

Doxazosin is an α-1 adrenergic receptor blocker that inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the α-1 receptors on the membrane of vascular smooth muscle cells. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity. 了解更多

Sertindole is one of the newer antipsychotic medications and a neuroleptic. Like the other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of schizophrenia. 了解更多

Icatibant (HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively. 了解更多

Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome. 了解更多

Tetracaine is a potent local anesthetic. It alters the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. 了解更多

Pizotifen is a serotonin antagonist which acts mainly at the 5-HT1, 5-HT2A, and 5HT2C receptors with some antihistamine activity. 了解更多

Peretinoin, also known as NIK-333 , orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells. 了解更多

Baclofen is a GABA agonist specific for GABA-B receptors. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission. 了解更多

Flurandrenolide is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Flurandrenolide exerts its effects by interacting with specific cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. 了解更多

Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors. 了解更多

BMS-193885 is a potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over ??1, α1, Y2, Y4 and Y5 receptors respectively. 了解更多

OP-3633 is a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (IC50 = 29 nM). 了解更多

Cevimeline (AF-102B) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome. 了解更多

GSK5182 is a highly selective inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM and does not interact with other nuclear receptors, including ERRα or ERα. 了解更多

Balovaptan (RG7314) is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism. 了解更多

Imidazoleacetic acid is an endogenous ligand that stimulates imidazole receptors. 了解更多

Dicarbine blocks dopamine receptors in various brain parts and prevents the depression of the conditioned defence reflexes caused by stimulation of the mesencephalic portion of the reticular formation. Dicarbine could be used to treat patients with schizophrenia and alcoholic psychosis in clinical. 了解更多

ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A2A receptor, with Kis of 8 nM and 33 nM for A2A and A1 receptors, respectively. 了解更多

RWJ-51204 is a partial agonist of GABA(A) receptor, with Ki of 0.2-2 nM to the benzodiazepine site on GABA(A) receptors. 了解更多

Bamirastine inhibits ligand binding to recombinant human histamine H1 receptors (rhH1R) with an IC50 value of 17.3 nM. 了解更多

CP-809101 is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. 了解更多

Orexin A human, rat, mouse is a 33 amino acid excitatory neuropeptide. Orexin A human, rat, mouse works on 2 specific G protein-coupled receptors (GPCRs): orexin-1 (OX1) and orexin-2 (OX2). 了解更多

PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors. 了解更多

AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors. 了解更多

JDTic is a highly selective antagonist for the κ-opioid receptor; without affecting the μ- or δ-opioid receptors. 了解更多