ROCK

Catalog No.Inhibitor Name ROCKROCK1ROCK2Other
A11001Y-27632 2HCl
*
*
A10928Thiazovivin
*
A10381Fasudil HCl
*
PKA,PKG,PKC
A10441GSK429286A
***
**
A13067RKI-1447
***
***
A12348GSK269962
****
****
MSK1,RSK1
A15888Ripasudil
**
**
A15239KD025
**
A12464AT13148
***
****
PKA,p70S6K,Akt1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. SR 3677 dihydrochloride

    Catalog No. A12674
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    ROCK 抑制剂
    SR 3677 dihydrochloride是一种有效的选择性Rho激酶抑制剂(ROCK-II和ROCK-I的IC50值分别为3和56 nM)。 了解更多
  2. Hydroxyfasudil hydrochloride

    Catalog No. A15119
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    ROCK 抑制剂
    Hydroxyfasudil hydrochloride是法舒地尔的代谢产物,是一种有效的Rho激酶抑制剂和血管舒张剂。 了解更多
  3. Hydroxyfasudil

    Catalog No. A15118
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    ROCK 抑制剂
    Hydroxyfasudil是法舒地尔的代谢产物,是有效的Rho激酶抑制剂和血管舒张剂。 了解更多
  4. ROCK inhibitor

    Catalog No. A15225
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    ROCK 抑制剂
    ROCK inhibitor是人类ROCK-1和ROCK-2同工酶的高效抑制剂,IC50值分别为0.6和1.1 nM。 了解更多
  5. ROCK inhibitor-1

    Catalog No. A15226
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    ROCK 抑制剂
  6. LX7101

    Catalog No. A16211
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    LIMK2 抑制剂
    LX7101是基于吡咯并嘧啶的局部递送的LIM域激酶2(LIMK2)抑制剂,LIM域激酶2是与眼内压调节相关的激酶。 了解更多
  7. Ripasudil

    Catalog No. A15888
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    ROCK inhibitor
    Ripasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension. 了解更多
  8. SAR407899 HCl

    Catalog No. A15921
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    ROCK 抑制剂
    SAR407899是一种有效且选择性的Rho激酶抑制剂,具有良好的抗高血压活性。 了解更多
  9. SLx-2119 (KD025)

    Catalog No. A15239
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    ROCK2 抑制剂
    SLx-2119 (KD025)是ROCK2的小分子和选择性抑制剂,IC50为105 nM。在ROCK1上的选择性> 200倍(IC50 = 24 uM)。 了解更多
  10. Glycyl-H 1152 2HCl

    Catalog No. A13659
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    ROCK 抑制剂
    Glycyl-H 1152 2HCl是一种选择性有效的ROCK抑制剂(ROCKII,Aurora A,CAMKII,PKG,PKA和PKC的IC50值分别为0.0118、2.35、2.57、3.26,> 10和> 10 uM。) 了解更多
  11. H-1152 dihydrochloride

    Catalog No. A15102
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    ROCK 抑制剂
    H-1152 dihydrochloride是一种异喹啉磺酰胺衍生物,是Rho激酶的一种更特异,更强且可透过膜的抑制剂,Ki值为1.6 nM,但对其他丝氨酸/苏氨酸激酶的抑制作用较弱。 了解更多
  12. H-1152

    Catalog No. A15101
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    ROCK 抑制剂
    H-1152是一种异喹啉磺酰胺衍生物,是Rho激酶的一种更特异,更强且可透过膜的抑制剂,Ki值为1.6 nM,但对其他丝氨酸/苏氨酸激酶的抑制作用较差。 了解更多
  13. chroman 1

    Catalog No. A15045
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    ROCK 抑制剂
    Chroman 1 是一种高效且选择性的ROCK II抑制剂。 了解更多
  14. AT13148

    Catalog No. A12464
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    multi-AGC kinase 抑制剂
    AT13148是一种新型多AGC激酶抑制剂,具有强大的药效和抗肿瘤活性,与其他AKT抑制剂相比,具有独特的作用机理。 了解更多
  15. Y-33075

    Catalog No. A11610
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    ROCK 抑制剂
    Y-33075是ROCK(Rho相关的卷曲螺旋形成蛋白激酶)抑制剂。 了解更多
  16. RKI-1447

    Catalog No. A13067
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    ROCK1/ROCK2 抑制剂
    RKI-1447是Rho相关ROCK激酶的有效抑制剂,在乳腺癌中具有抗侵袭和抗肿瘤活性。 了解更多
  17. HA-1077 dihydrochloride

    Catalog No. A13785
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    ROCK 抑制剂
    HA-1077 dihydrochloride通过充当细胞内Ca2+拮抗剂来抑制血管平滑肌收缩。 了解更多
  18. GSK429286A

    Catalog No. A10441
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    ROCK 抑制剂
    GSK429286A是含有蛋白激酶(ROCK)的Rho相关卷曲螺旋的细胞渗透性选择性小分子抑制剂。 了解更多
  19. T56-LIMKi

    Catalog No. A12266
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    LIMK2 inhibitor
    T56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM. 了解更多
  20. ROCK inhibitor-2

    Catalog No. A18912
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    ROCK1/ROCK2 inhibitor
    ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively. 了解更多
  21. R-10015

    Catalog No. A18806
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    LIMK inhibitor
    R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1. 了解更多
  22. Y-33075 dihydrochloride

    Catalog No. A11611
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    ROCK inhibitor
    Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM. 了解更多
  23. Y-27632

    Catalog No. A21448
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    ROCK-I/ROCK-II inhibitor
    Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively. 了解更多
  24. Fasudil

    Catalog No. A21628
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    ROCK inhibitor
    Fasudil (HA-1077; AT877), is a nonspecific ROCK inhibitor and also has inhibitory effect on protein kinases. 了解更多
  25. BMS-3

    Catalog No. A20999
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    LIMK inhibitor
    BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. 了解更多
  26. BDP5290

    Catalog No. A16966
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    ROCK and MRCK 抑制剂
    BDP5290是ROCK和MRCK的有效抑制剂,对ROCK1,ROCK2,MRCKα和MRCKβ的IC50分别为5 nM,50 nM,10 nM和100 nM。 了解更多
  27. BMS-5

    Catalog No. A12839
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    LIMK 抑制剂
    BMS-5是一种有效的LIMK抑制剂,对LIMK1和LIMK2的IC50分别为7 nM和8 nM。 了解更多
  28. RKI-1313

    Catalog No. A10899
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    ROCK 抑制剂
    RKI-1313是RKI-1447的阴性对照,RKI-1447是Rho相关的ROCK激酶的有效抑制剂,在乳腺癌中具有抗侵袭和抗肿瘤活性。 了解更多
  29. Thiazovivin

    Catalog No. A10928
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    ROCK 抑制剂
    Thiazovivin是一种Rho相关激酶(ROCK)的选择性抑制剂。 了解更多
  30. GSK 269962

    Catalog No. A12348
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    ROCK 抑制剂
    GSK 269962是一种强效Rho激酶(ROCK)抑制剂(重组人ROCK1和ROCK2的IC50值分别为1.6和4 nM)。 了解更多
  31. Fasudil HCl (HA-1077)

    Catalog No. A10381
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    ROCK 抑制剂
    Fasudil HCl (HA-1077)是一种环状核苷酸依赖性蛋白激酶抑制剂和Rho相关激酶抑制剂(IC50 = 10.7μM)。 了解更多
  32. Y-27632 2HCl

    Catalog No. A11001
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    ROCK 抑制剂
    Y-27632是一种Rho相关的线圈激酶(ROCK)抑制剂,可提高人类胚胎干细胞(hESCs)的克隆效率。比对其他激酶包括PKC,cAMP依赖性蛋白激酶,MLCK和PAK的作用强200多倍。 了解更多

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