“abl”的搜索结果

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  1. Tianeptine sodium

    Catalog No. A10931
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    5-HT Receptor 激动剂
    Tianeptine钠是体内和体外的选择性5-羟色胺再摄取促进剂(SSRE)。 了解更多
  2. TSU-68 (Orantinib, SU6668)

    Catalog No. A10953
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    PDFGRβ 抑制剂
    TSU-68 (Orantinib,SU6668)在无细胞试验中具有8 nM的Ki对PDGFR自磷酸化的最大效力,但也强烈抑制Flk-1和FGFR1反磷酸化,对IGF-1R,Met,Src, Lck,Zap70,Abl和CDK2; 不抑制EGFR。 了解更多
  3. TAK-733

    Catalog No. A11040
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    MEK 抑制剂
    TAK-733是一种有效的,选择性的MEK变构抑制剂,作用于MEK1,IC50为3.2 nM,抑制Abl1,AKT3,c-RAF,CamK1,CDK2及c-Met等活性。 了解更多
  4. OSI-906

    Catalog No. A11053
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    IGF-1R 抑制剂
    OSI-906是一种选择性IGF-1R抑制剂,在无细胞试验中IC50为35 nM;对InsR抑制作用适中,IC50为75 nM,对Abl,ALK,BTK,EGFR, FGFR1/2,PKA等没有抑制活性。 了解更多
  5. TAK-901

    Catalog No. A11067
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    Aurora Kinase A/B 抑制剂
    TAK-901是一种新型Aurora A/B抑制剂,IC50为21 nM/15 nM。它不是细胞JAK2,c-Src或Abl的有效抑制剂。 了解更多
  6. PP121

    Catalog No. A11207
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    PI3K 抑制剂
    PP121是一种作用于PDGFR,Hck,mTOR,VEGFR2,Src和Abl的多靶点抑制剂,IC50分别为2 nM,8 nM,10 nM,12 nM,14 nM和18 nM,也抑制DNA-PK,IC50为60 nM。 了解更多
  7. 1-NA-PP1

    Catalog No. A13232
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    Src Kinase 抑制剂
    1-NA-PP1是v-Src和c-Fyn以及c-Abl的选择性抑制剂。 了解更多
  8. NU 9056

    Catalog No. A13378
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    KAT5 (Tip60) HAT 抑制剂
    NU9056是一种选择性KAT5(Tip60)HAT抑制剂。对于KAT5,p300,pCAF和GCN5,IC50值分别为<2、60、36和> 100μM。抑制前列腺癌细胞系和蛋白质块中的蛋白质乙酰化。 了解更多
  9. BC2059

    Catalog No. A14381
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    beta-catenin inhibitor
    BC2059 is an orally bioavailable and potent beta-catenin inhibitor. 了解更多
  10. Z-FL-COCHO

    Catalog No. A13502
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    Cathepsin S 抑制剂
    Z-FL-COCHO是新型的组织蛋白酶S抑制剂。 了解更多
  11. Dasatinib hydrochloride

    Catalog No. A15060
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    Src 抑制剂
    Dasatinib hydrochloride是一种有效的Abl/Src双重抑制剂,IC50分别<1 nM/0.8 nM。还可以抑制c-Kit(WT/c-Kit(D816V),IC50为79 nM/37 nM。有效,选择性Raf激酶抑制剂能够抑制野生型B-Raf,B-RafV600E和c -Raf的IC50值分别为3.2、0.8和5.0 nM。 了解更多
  12. Masitinib mesylate

    Catalog No. A15152
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    KIT/PDGFR 抑制剂
    Masitinib mesylate是Kit和PDGFRα/β的新型抑制剂,IC50为200 nM和540 nM/800 nM,对ABL和c-Fms的抑制作用较弱。 了解更多
  13. NVP-BGJ398 phosphate

    Catalog No. A15194
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    FGFR 抑制剂
    NVP-BGJ398 phosphate是一种新型的选择性泛特异性FGFR抑制剂,对FGFR1,FGFR2和FGFR3的IC50分别为0.9、1.4和1 nM。与FGFR4和VEGFR2相比,对FGFR具有40倍以上的选择性,并且对Abl,Fyn,Kit,Lck,Lyn和Yes的活性很小。 了解更多
  14. Dihydroethidium

    Catalog No. A15930
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    cell-permeable blue fluorescent dye
    Dihydroethidium是一种可透过细胞的蓝色荧光染料。 了解更多
  15. AGN 205327

    Catalog No. A16295
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    RAR 激动剂
    AGN 205327是一种有效的合成RARs激动剂,对RARα/β/γ的EC50分别为3766/734/32 nM;对RXR无抑制作用。 了解更多
  16. WEHI-539 hydrochloride

    Catalog No. A13327
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    Bcl-xL 抑制剂
    WEHI-539 hydrochloride是BCL-xL的小分子抑制剂,IC50值为1.1 nM。 了解更多
  17. Dasatinib Monohydrate

    Catalog No. A16320
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    Dasatinib Monohydrate是一种新型,有效且多靶点的抑制剂,靶向Abl,Src和c-Kit,IC50分别<1 nM,0.8 nM和79 nM。 了解更多
  18. TSSC4 Human

    Catalog No. AP0210
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    Tumor Suppressing Subtransferable Candidate 4, Human Recombinant 了解更多
  19. RABL5 Human

    Catalog No. AP0681
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    RAB, Member RAS Oncogene Family-Like 5 Human Recombinant 了解更多
  20. MYLPF Human

    Catalog No. AP1659
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    Myosin Light chain, Phosphorylatable, Fast Skeletal Muscle Human Recombinant 了解更多
  21. CARHSP1 Human

    Catalog No. AP1737
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    Calcium Regulated Heat Stable Protein 1 Human Recombinant 了解更多
  22. SMAC/DIABLO Human

    Catalog No. AP2030
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    SMAC/DIABLO Human Recombinant 了解更多
  23. SMAC/DIABLO Antibody

    Catalog No. AP3131
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    SMAC/DIABLO, Mouse Anti Human 了解更多
  24. FGF 2 Human, Thermostable

    Catalog No. AP3454
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    Fibroblast Growth Factor-basic Human Recombinant, Thermostable 了解更多
  25. DUT Pyrococcus Fruriosus

    Catalog No. AP4457
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    Thermostable dUTPase Pyrococcus Fruriosus Recombinant 了解更多
  26. AZ32

    Catalog No. A16814
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    ATM 抑制剂
    AZ32是ATM激酶的特异性抑制剂,对小鼠具有良好的BBB渗透性,ATM酶的IC50值<0.0062 uM。它对ATR有足够的选择性,并且具有较高的细胞通透性。 了解更多
  27. ML355

    Catalog No. A18349
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    12-Lipoxygenase (12-LOX) inhibitor
    ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties. 了解更多
  28. Afloqualone

    Catalog No. A17276
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    GABA receptor agonist
    Afloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site. 了解更多
  29. Harmine

    Catalog No. A17316
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    Harmine, also known as telepathine, is a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds. It occurs in a number of different plants, most notably the Middle Eastern plant harmal or Syrian rue (Peganum harmala) and the South American vine Banisteriopsis caapi (also known as "yage" or "ayahuasca"). Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a RIMA. Harmine selectively binds to MAO-A but does not inhibit the variant MAO-B. 了解更多
  30. Pyrogallol

    Catalog No. A17318
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    Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions. 了解更多
  31. (+)-α-Lipoic acid

    Catalog No. A17343
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    Lipoic Acid, also known as R-(+)-alpha-Lipoic acid, is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism. It is also manufactured and is available as a dietary supplement in some countries where it is marketed as an antioxidant, and is available as a pharmaceutical drug in other countries. 了解更多
  32. Oxprenolol HCl

    Catalog No. A17368
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    Non-selective β antagonist
    Oxprenolol is an orally bioavailable β-adrenergic receptor (β-AR) antagonist (Ki = 7.10 nM in a radioligand binding assay using rat heart tissue). It is non-selective and inhibits both β1- and β2-ARs (Kds = 2.09 and 1.35 nM in isolated rat heart and uterus, respectively). Oxprenolol is selective for β-ARs over serotonin (5-HT) receptors in rat sarcolemmal membrane preparations (IC50s = 4.13 and 23,300 nM, respectively), but it binds to 5-HT1A receptors in rat hippocampus and 5-HT1B in rat striatum (Kis = 94.2 and 642 nM, respectively). 了解更多
  33. AX-024 hydrochloride

    Catalog No. A18332
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    TNF receptor inhibitor
    AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases. 了解更多
  34. PF-6260933

    Catalog No. A18326
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    MAP4K4 inhibitor
    PF-06260933 is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM. 了解更多
  35. JNJ-38877618

    Catalog No. A18325
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    c-Met inhibitor
    JNJ-38877618 is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively. 了解更多
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    SNJ-1945

    Catalog No. A17243
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    Calpain inhibitor
    SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. 了解更多
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    SAR-7334 HCl

    Catalog No. A17237
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    TRPC6 inhibitor
    SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected. 了解更多
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    DC661

    Catalog No. A17236
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    PPT1 inhibitor
    DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor. DC661 inhibits autophagy. DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ). 了解更多
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    KL1333

    Catalog No. A17234
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    NAD+ Modulator
    KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL-1333 Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. 了解更多
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    PUN30119

    Catalog No. A17232
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    PUN30119, also known as Imidazole ketone erastin (IKE), is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications. 了解更多
  36. AMG-176

    Catalog No. A18360
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    MCL-1 inhibitor
    AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a Ki of 0.13 nM. 了解更多
  37. 4-Aminosalicylic acid

    Catalog No. A17558
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    antitubercular agent
    Aminosalicylic Acid, also known as Para-aminosalicylic acid (PAS), is one of the last remaining drugs available to treat extensively drug-resistant (XDR) tuberculosis. It is an antitubercular agent often administered in association with ISONIAZID. 了解更多
  38. Lactose

    Catalog No. A17807
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    Lactose is milk sugar. It is a disaccharide composed of one galactose and one glucose molecule. In the pharmaceutical industry, lactose is used to help form tablets because it has excellent compressibility properties. 了解更多
  39. N-Acetylglucosamine

    Catalog No. A17841
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    Elastase release inhibitor
    Acetylglucosamine or N-acetylglucosamine is potentially for the treatment of irritable bowel syndrome. N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc has been reported to be an inhibitor of elastase release from human polymorphonuclear leukocytes (range 8?C17% inhibition), however this is much weaker than the inhibition seen with N-acetylgalactosamine (range 92?C100%). 了解更多
  40. Tucidinostat (Chidamide)

    Catalog No. A17861
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    HDAC inhibitor
    Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9. 了解更多
  41. Cangrelor Tetrasodium

    Catalog No. A17919
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    P2Y12 receptors inhibitor
    Cangrelor Tetrasodium is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. It is a modified ATP derivative stable to enzymatic degradation. Unlike clopidogrel (Plavix), which is a prodrug, cangrelor is an active drug not requiring metabolic conversion. 了解更多
  42. D-Pantethine

    Catalog No. A17945
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    Pantethine is a dimeric form of pantothenic acid, is an intermediate in the production of Coenzyme A, is available as a dietary supplement, and is used to treat acne and improve the blood-cholesterol profile. 了解更多
  43. Pipobroman

    Catalog No. A18065
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    Pipobroman (trade names Vercite, Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. 了解更多
  44. Lusutrombopag

    Catalog No. A18089
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    thrombopoietin (TPO) receptor agonist
    Lusutrombopag, also known as S-888711, is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist being developed by Shionogi for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery. 了解更多
  45. Lasofoxifene Tartrate

    Catalog No. A18097
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    selective Estrogen receptor modulator
    Lasofoxifene tartrate is a third-generation selective estrogen receptor modulator. 了解更多

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