Immunology & Inflammation

产品 1 到 50 共 115个

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  1. SC 57461A

    Catalog No. A15312
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    LTA4 hydrolase 抑制剂
    SC 57461A是体外有效的重组人白三烯A4水解酶抑制剂(Askonas等,2002)。 了解更多
  2. MRT67307

    Catalog No. A11485
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    SIK/TBK-1/IKKe 抑制剂
    MRT67307是一种强效双IKK?和TBK1抑制剂,IC50分别为160和19 nM。 了解更多
  3. ARN-3236

    Catalog No. A18725
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    SIK2 inhibitor
    ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L. 了解更多
  4. YKL-06-061

    Catalog No. A18836
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    SIK inhibitor
    YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor. 了解更多
  5. HG-9-91-01

    Catalog No. A21004
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    SIK inhibitor
    HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. 了解更多
  6. BEC HCl

    Catalog No. A15881
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    arginase 抑制剂
    BEC HCl是一种缓慢结合的竞争性精氨酸酶抑制剂,精氨酸酶II和大鼠精氨酸酶I的Ki分别为0.31 μM(pH7.5)和0.4-0.6 μM。 了解更多
  7. CB-1158

    Catalog No. A16929
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    Arginase 抑制剂
    CB-1158,也称为INCB01158,是一种有效的口服活性精氨酸酶抑制剂,IC50 = 89nM。 了解更多
  8. CB-1158

    Catalog No. A16864
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    arginase 抑制剂
    CB-1158,也称为INCB01158,是一种有效的口服精氨酸酶抑制剂,IC50 = 89 nM。 了解更多
  9. nor-NOHA acetate

    Catalog No. A21673
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    Arginase inhibitor
    nor-NOHA acetate is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. 了解更多
  10. Arginase inhibitor 1

    Catalog No. A21007
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    arginases I and II inhibitor
    Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively. 了解更多
  11. AT 56

    Catalog No. A13032
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    L-PGDS 抑制剂
    AT-56是脂环素型前列腺素D合酶(L-PGDS)的口服活性抑制剂(Ki = 75μM,IC50 = 95μM)。 了解更多
  12. HPGDS inhibitor 1

    Catalog No. A12258
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    HPGDS 抑制剂
    HPGDS inhibitor 1是一种新的选择性造血前列腺素d合酶(HPGDS)抑制剂,IC50值为0.7 nM。 了解更多
  13. SAR191801

    Catalog No. A14444
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    hPGDS 抑制剂
    SAR191801是一种hPGDS抑制剂,在荧光偏振分析或EIA分析中,IC50为12 nM。 了解更多
  14. HPGDS inhibitor 2

    Catalog No. A18390
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    H-PGDS 抑制剂
    HPGDS inhibitor 2 is a highly potent and selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with an IC50 of 9.9 nM. 了解更多
  15. Apocynin (Acetovanillone)

    Catalog No. A11989
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    NADPH-oxidase 抑制剂
    Apocynin (Acetovanillone)是NADPH氧化酶抑制剂。 了解更多
  16. ML 171

    Catalog No. A13360
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    NOX1 抑制剂
    ML 171是一种有效的、选择性的NADPH-oxidase抑制剂,对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。 了解更多
  17. GKT137831

    Catalog No. A14433
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    NOX1/4 抑制剂
    GKT137831是针对NOX1和NOX4酶的一流抑制剂。 了解更多
  18. APX-115

    Catalog No. A18737
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    Nox inhibitor
    APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury. 了解更多
  19. GSK2795039

    Catalog No. A20998
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    NOX2 inhibitor
    GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis. 了解更多
  20. PD1-PDL1 inhibitor 2

    Catalog No. A15906
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    PD-1/PD-L1 interaction 抑制剂
    PD1-PDL1 inhibitor 2 是PD-1/PD-L1相互作用抑制剂。 了解更多
  21. PD1-PDL1 inhibitor 1

    Catalog No. A15882
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    PD1-PDL1 inhibitor 1 是PD-1/PD-L1相互作用抑制剂。 了解更多
  22. MI 2

    Catalog No. A12928
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    MALT1 抑制剂
    MI 2直接与MALT1结合并在体外和体内抑制活化的B细胞样弥漫性大B细胞淋巴瘤(ABC-DLBCL)。 了解更多
  23. MLT-748

    Catalog No. A18954
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    MALT1 inhibitor
    MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. 了解更多
  24. MLT-747

    Catalog No. A18942
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    MALT1 inhibitor
    MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM. 了解更多
  25. RTA-408

    Catalog No. A14417
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    Nrf2 抑制剂
    RTA-408是一种合成的三萜类化合物,可有效激活抗氧化转录因子Nrf2并抑制促炎转录因子NF-kB。 了解更多
  26. Brusatol

    Catalog No. A16893
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    Nrf2 抑制剂
    Brusatol是一种生化物质,从Brucea javanica植物中分离出来,可抑制Nrf2。 了解更多
  27. ML-385

    Catalog No. A17172
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    NRF2 抑制剂
    ML-385是核因子红系2相关因子2(Nrf2)的抑制剂,IC50值为1.9μM。 了解更多
  28. Nrf2-IN-1

    Catalog No. A12561
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    Nrf2 inhibitor
    Nrf2-IN-1 (Compound 4f) is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2), acts as a promising agent in acute myeloid leukemia (AML) therapy. 了解更多
  29. Diphenyleneiodonium chloride

    Catalog No. A13359
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    GPR3 激动剂/NOS/ NADPH oxidases 抑制剂
    Diphenyleneiodonium是一种有效的不可逆的巨噬细胞抑制剂NOS2(iNOS)和内皮细胞NOS3(eNOS)抑制剂。 了解更多
  30. 1400W Dihydrochloride

    Catalog No. A13583
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    INOS 抑制剂
    1400W Dihydrochloride是一种缓慢,紧密结合,有效和高度选择性的诱导型一氧化氮合酶抑制剂(Kd = 7 nM)。对nNOS和eNOS具有选择性(Ki值分别为2和50μM)。细胞可渗透并在体内具有活性。 了解更多
  31. Gw274150

    Catalog No. A12710
    iNOS 抑制剂
    GW274150是有效且高度选择性的iNOS抑制剂,可减少实验性肾脏缺血/再灌注损伤。 了解更多
  32. Asymmetric dimethylarginine

    Catalog No. A18704
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    NOS inhibitor
    Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. 了解更多
  33. L-NIO dihydrochloride

    Catalog No. A13027
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    NOS inhibitor
    L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor. 了解更多
  34. Dihydromyricetin (Ampeloptin)

    Catalog No. A10252
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    Dihydropyrimidinase 抑制剂
    Dihydromyricetin (Ampeloptin)是具有良好性能的天然抗氧化剂。 了解更多
  35. Febuxostat (TEI-6720)

    Catalog No. A10382
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    xanthine oxidase 抑制剂
    Febuxostat (TEI-6720)是黄嘌呤氧化酶的非嘌呤抑制剂(Ki = 1.2 nM)。 了解更多
  36. Allopurinol sodium

    Catalog No. A10056
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    xanthine oxidase inhibitor
    Allopurinol sodium是次黄嘌呤(体内天然存在的嘌呤)的结构异构体,是黄嘌呤氧化酶的抑制剂。 了解更多
  37. MSX-122

    Catalog No. A12596
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    CXCR4 抑制剂
    MSX-122是口服可生物利用的CXCR4抑制剂(IC50 =?10 nM),具有潜在的抗肿瘤和抗病毒活性。CXCR4抑制剂MSX-122与趋化因子受体CXCR4结合,阻止基质衍生因子-1(SDF-1)与CXCR4受体和受体激活结合,这可能导致肿瘤细胞增殖和迁移减少。 了解更多
  38. Reparixin

    Catalog No. A12383
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    CXCL8/CXCR1/2 抑制剂
    Reparixin是两种CXCL8受体CXCR1/2的有效抑制剂,它抑制CXCR2介导的细胞迁移(IC50 = 100 nM),而它强烈地阻断CXCR1介导的趋化性(IC50 = 1 nM)。 了解更多
  39. Reparixin L-lysine salt

    Catalog No. A15219
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    CXCL8 receptor 抑制剂
    Reparixin L-lysine salt是CXCL8受体的抑制剂,也抑制CXCR1和CXCR2的活化,已显示在各种损伤模型中减弱了炎症反应。 了解更多
  40. VGX-1027

    Catalog No. A12548
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    TLR4 抑制剂
    VGX-1027通过抑制Toll样受体4(TLR4)信号传导来显示免疫调节和抗炎活性。 了解更多
  41. TLR2-IN-C29

    Catalog No. A17160
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    TLR 抑制剂
    TLR2-IN-C29是TLR2/1和TLR2/6信号传导的抑制剂。 了解更多
  42. TAK-242 S enantiomer

    Catalog No. A15253
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    TLR4 抑制剂
    TAK-242的S对映体。TAK-242(Resatorvid),Toll样受体(TLR)4信号转导的小分子抑制剂。TAK-242用于治疗败血症和败血性休克。 了解更多
  43. MD2-TLR4-IN-1

    Catalog No. A18452
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    MD2-TLR4 inhibitor
    MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. 了解更多
  44. Resatorvid

    Catalog No. A11543
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    TLR4 inhibitor
    Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor and plays pivotal role in various inflammatory diseases. 了解更多
  45. AN-3485

    Catalog No. A20989
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    TLR inhibitor
    AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM. 了解更多
  46. Cenicriviroc

    Catalog No. A13643
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    CCR2/CCR5 抑制剂
    Cenicriviroc是用于治疗HIV感染的实验性候选药物.Cenicriviroc是CCR2和CCR5受体的抑制剂,可使其充当阻止病毒进入人体细胞的进入抑制剂。 了解更多
  47. Aplaviroc

    Catalog No. A13471
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    CCR5 entry 抑制剂
    Aplaviroc是一种CCR5进入抑制剂,用于治疗HIV感染。 了解更多
  48. Cenicriviroc Mesylate

    Catalog No. A17028
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    CCR2/5 receptors 抑制剂
    Cenicriviroc(TAK-652,TBR-652)是CCR2和CCR5受体的抑制剂,可使其充当防止病毒进入人细胞的进入抑制剂 了解更多
  49. ML604086

    Catalog No. A18969
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    CCR8 抑制剂
    ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations. 了解更多
  50. Ibuprofen (Advil)

    Catalog No. A10461
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    COX-1 抑制剂
    Ibuprofen (Advil)是一种非甾体抗炎药(NSAID),靶向COX-1,IC50为13 μM。 了解更多

产品 1 到 50 共 115个

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