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使用 'JAK2' 作为标签的产品

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AG-490

Catalog No. A10047
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EGFR 抑制剂

AG 490是EGF受体酪氨酸激酶的选择性抑制剂 (EGFR和ErbB2的IC50值分别为2和13.5μM)。也抑制对Lck，Lyn，Btk，Syk和Src无活性的JAK2。了解更多

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- Matozaki M, .et al. Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance, Exp Cell Res, 2019, Feb 15. pii: S0014-4827(18)31030-9 PMID: 30776355
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AZ-960

Catalog No. A10104
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JAK2抑制剂

AZ-960是一种有效的，选择性的和ATP竞争性的JAK2抑制剂，在体外抑制JAK2激酶的Ki为0.45 nM，并诱导成年T细胞白血病（ATL）细胞的生长停滞和凋亡了解更多

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AZD1480

Catalog No. A10110
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JAK 抑制剂

AZD1480是一种新型有效的小型JAK2抑制剂，IC50为0.26 nM。了解更多

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- Simona Moravcova, .et al. The Circadian Rhythms of STAT3 in the Rat Pineal Gland and Its Involvement in Arylalkylamine-N-Acetyltransferase Regulation, Life (Basel), 2021, Oct 18;11(10):1105 PMID: 34685476
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BMS-911543

Catalog No. A11241
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JAK 抑制剂

BMS-911543是一种有效的、选择性JAK2小分子抑制剂。了解更多

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CEP33779

Catalog No. A12808
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JAK2 抑制剂

CEP33779是选择性JAK2抑制剂，IC50为1.8 nM。了解更多

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Cyt387 (Momelotinib)

Catalog No. A10263
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JAK 抑制剂

Cyt387 (Momelotinib)是Janus激酶JAK1和JAK2的抑制剂，可作为ATP竞争者，IC50值分别为11和18 nM。了解更多

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- Alex Bainbridge, .et al. IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway, Nucleic Acids Research, 2020, April
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Decernotinib

Catalog No. A14012
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JAK3 抑制剂

Decernotinib是Vertex开发的口服选择性Janus激酶3（JAK3）抑制剂。了解更多

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Filgotinib

Catalog No. A14232
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JAK 抑制剂

Filgotinib是一种选择性的JAK1抑制剂，对于JAK1，JAK2，JAK3和TYK2的IC50分别为10 nM，28 nM，810 nM和116 nM。了解更多

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FLLL32

Catalog No. A15911
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JAK2 抑制剂

FLLL32是一种有效的JAK2/STAT3双重抑制剂，IC50 <5 uM。了解更多

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Go 6976

Catalog No. A12419
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PKC 抑制剂

Go6976是一种有效的PKC抑制剂，对PKC（大鼠脑），PKCα和PKCβ1的IC50分别为7.9 nM，2.3 nM和6.2 nM。也是JAK2和Flt3的有效抑制剂。了解更多

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INCB018424 (Ruxolitinib)

Catalog No. A11041
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JAK1/2 抑制剂

INCB018424 (Ruxolitinib)是有效和选择性的Janus相关激酶JAK1/2抑制剂，对JAK1，JAK2和JAK3的IC50分别为2.7、4.5和332 nM。了解更多

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- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Daniel Doheny, .et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis, Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
- Rasmus Siersbek, .et al. IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis, Cancer cell, 2020, Jul 6;S1535-6108(20)30311-1 PMID: 32679107
- Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
- Kagoya Y, .et al. JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2., Blood., 2014, Nov 6;124(19):2996-3006 PMID: 25217696
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PP2

Catalog No. A12723
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Src 抑制剂

PP2是Src家族酪氨酸激酶的选择性抑制剂。抑制p56lck和p59fynT（IC50值分别为4和5 nM）。在ZAP-70和JAK2上显示的选择性> 10000倍。中度抑制CSK（IC50 = 0.73μM）。了解更多

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TG-101348 (Fedratinib, SAR302503)

Catalog No. A11082
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JAK2/FLT3 抑制剂

TG-101348 (Fedratinib,SAR302503)是Janus相关激酶2的口服生物利用型，ATP竞争性和选择性抑制剂，在无细胞试验中IC50为3 nM，作用于JAK2比作用于JAK1和JAK3选择性高35和334倍,具有潜在的抗肿瘤活性。了解更多

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TG101209

Catalog No. A11180
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JAK2 抑制剂

TG101209是一种新型的JAK2抑制剂，无细胞试验中IC50为6 nM，对Flt3和RET作用效果稍弱，IC50分别为25 nM和17 nM，作用于JAK2比作用于JAK3选择性高30倍左右，对JAK2V617F和MPLW515L/K突变型敏感。在多发性骨髓瘤中具有显着的体外活性，并且对CD45+骨髓瘤细胞显示出优先的细胞毒性。了解更多

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WP1066

Catalog No. A11795
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JAK 抑制剂

WP1066是一种新型的JAK2抑制剂，可抑制携带JAK2 V617F突变的类人甲状腺细胞增殖并诱导其凋亡。了解更多

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- Simona Moravcova, .et al. The Circadian Rhythms of STAT3 in the Rat Pineal Gland and Its Involvement in Arylalkylamine-N-Acetyltransferase Regulation, Life (Basel), 2021, Oct 18;11(10):1105 PMID: 34685476

Adooq Bioscience

使用 'JAK2' 作为标签的产品

AG-490

AZ-960

AZD1480

BMS-911543

CEP33779

Cyt387 (Momelotinib)

Decernotinib

Filgotinib

FLLL32

Go 6976

INCB018424 (Ruxolitinib)

PP2

TG-101348 (Fedratinib, SAR302503)

TG101209

WP1066

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