你的浏览器似乎禁用了 JavaScript。
您必须在浏览器中启用JavaScript才能使用本网站的功能。

微信关注
申请试用装

主页 /
搜索结果：“rasgap ras p21”

“rasgap ras p21”的搜索结果

Quick View
Pirarubicin

Catalog No. A10735
Quick View

添加到收藏
Topoisomerase II 抑制剂

Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II（拓扑异构酶II）相互作用并抑制DNA复制。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Krishna K Ramajayam, .et al. Selecting ideal drugs for encapsulation in thermosensitive liposomes and other triggered nanoparticles, Int J Hyperthermia, 2022, 39(1):998-1009 PMID: 35876089
Quick View
Prednisone (Adasone)

Catalog No. A10752
Quick View

添加到收藏
Glucocorticoid Receptor 激动剂

Prednisone (Adasone)可降低粘膜TNF-a的产生，肠道通透性和NF-kB表达水平。了解更多

Bulk Inquiry
Quick View
Flumequine

Catalog No. A11861
Quick View

添加到收藏
Topoisomerase II 抑制剂

Flumequine是一种合成化学抗生素，可在回旋酶/拓扑异构酶水平上影响哺乳动物染色体和DNA的解链。抑制拓扑异构酶II， IC50为15 μM。了解更多

Bulk Inquiry
Quick View
Tegobuvir (GS-9190)

Catalog No. A11583
Quick View

添加到收藏
NS5B polymerase 抑制剂

Tegobuvir (GS-9190)是一种非核苷NS5B聚合酶抑制剂。了解更多

Bulk Inquiry
Quick View
T-705 (Favipiravir)

Catalog No. A11590
Quick View

添加到收藏
viral RNA polymerase 抑制剂

T-705 (Favipiravir)是一种有效的选择性RNA-dependent RNA polymerase抑制剂，在体外和体内均表现出有效的抗流感病毒活性。了解更多

Product Citations (9)

Bulk Inquiry Free Sample
- Satoko Yamaoka, .et al. Development of accelerated high-throughput antiviral screening systems for emerging orthomyxoviruses, Antiviral Res, 2022, Apr;200:105291 PMID: 35296419
- Crystal A Mendoza, .et al. The NF- κB inhibitor, SC75741, is a novel antiviral against emerging tick-borne bandaviruses, Antiviral Res, 2021, Jan;185:104993 PMID: 33296695
- Liva Checkmahomed, .et al. In Vitro Combinations of Baloxavir Acid and Other Inhibitors against Seasonal Influenza A Viruses, Viruses, 2020, Oct; 12(10): 1139 PMID: 33049959
- JE Comer, .et al. Filovirus Virulence in Interferon α,β and γ Double Knockout Mice, and Treatment with Favipiravir, Viruses, 2019, Feb 3;11(2). pii: E137 PMID: 30717492
- Ma J, .et al. Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo, Antiviral Res, 2018, Feb;150:112-122 PMID: 29253498
- Ji-Ae Kim, .et al. Favipiravir and Ribavirin Inhibit Replication of Asian and African Strains of Zika Virus in Different Cell Models, Viruses, 2018, Feb; 10(2): 72 PMID: 29425176
- Haejin Chun, .et al. Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment, Polym Chem, 2018, 9: 2116-2123
- Baz M, .et al. Combination Therapy with Oseltamivir and Favipiravir Delays Mortality but Does Not Prevent Oseltamivir Resistance in Immunodeficient Mice Infected with Pandemic A(H1N1) Influenza Virus, Viruses, 2018, Nov 3;10(11) PMID: 30400276
- Sehee Park, .et al. Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice, PLoS One., 2014, 9(7): e101325 PMID: 24992479
Quick View
Zaurategrast (CDP323)

Catalog No. A11614
Quick View

添加到收藏
VCAM-1 拮抗剂

Zaurategrast (CDP323)是与α4-整合素结合的血管细胞粘附分子1的小分子前药拮抗剂。了解更多

Product Citations (1)

Bulk Inquiry
- Mustafa Ahmadzai, .et al. Integrins are Mechanosensors That Modulate Human Eosinophil Activation, Front Immunol, 2015, 6: 525 PMID: 26539194
Quick View
Amrubicin

Catalog No. A12663
Quick View

添加到收藏
Topoisomerase II 抑制剂

Amrubicin是一种合成的蒽环类抗生素。它抑制DNA拓扑异构酶II。了解更多

Bulk Inquiry
Quick View
VCH-916

Catalog No. A12374
Quick View

添加到收藏
HCV NS5B polymerase 抑制剂

VCH-916是一种新型非核苷HCV NS5B聚合酶抑制剂。了解更多

Bulk Inquiry
Quick View
Firategrast (SB 683699)

Catalog No. A12787
Quick View

添加到收藏
α4β1/α4β7 integrin 拮抗剂

Firategrast (SB 683699)是一种口服可生物利用的alpha4 beta1/alpha4 beta7整联蛋白拮抗剂，旨在减少淋巴细胞向中枢神经系统（CNS）的运输。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Higuchi S, .et al. Inhibition of the integrin signal constitutes a mouse iPS cell niche, Dev Growth Differ, 2016, Sep;58(7):586-99 PMID: 27633818
Quick View
Gimatecan

Catalog No. A12856
Quick View

添加到收藏
topoisomerase I 抑制剂

Gimatecan是喜树碱的一种口服生物可利用的，半合成的亲脂类似物，喜树碱是一种从亚洲喜树树中提取的喹啉生物碱，具有潜在的抗肿瘤和抗血管生成活性。了解更多

Bulk Inquiry
Quick View
Epirubicin

Catalog No. A12409
Quick View

添加到收藏
Topoisomerase 抑制剂

Epirubicin是一种细胞可渗透的抗肿瘤抗生素。阿霉素的立体异构体，其心脏毒性降低。表柔比星的抗肿瘤作用是通过靶向和抑制Topo II（拓扑异构酶II）来介导的。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Xiu-wu Pan, .et al. Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy, Oncol Rep, 2016, Jan;35(1):334-42 PMID: 26496799
Quick View
Gatifloxacin

Catalog No. A10419
Quick View

添加到收藏
DNA gyrase/topoisomerase IV 抑制剂

Gatifloxacin是一种氟喹诺酮类抗生素，可抑制细菌dna回旋酶(IC50 = 0.109 ng/ml)和拓扑异构酶iv(IC50 = 13.8 ng/ml)。了解更多

Bulk Inquiry Free Sample
Quick View
Ofloxacin (DL8280)

Catalog No. A10666
Quick View

添加到收藏
Topoisomerase 抑制剂

Ofloxacin (DL8280)是一种合成的广谱抗菌剂。了解更多

Bulk Inquiry Free Sample
Quick View
GENZ-644282

Catalog No. A13206
Quick View

添加到收藏
topoisomerase 1 抑制剂

GENZ-644282是拓扑异构酶I的非喜树碱抑制剂，具有潜在的抗肿瘤活性。了解更多

Bulk Inquiry Free Sample
Quick View
Setrobuvir (ANA-598)

Catalog No. A13105
Quick View

添加到收藏
HCV Polymerase 抑制剂

Setrobuvir (ANA-598)是一种直接作用的抗病毒药物或DAA，是HCV RNA聚合酶的一种非核苷抑制剂。了解更多

Bulk Inquiry
Quick View
Beta-Lapachone

Catalog No. A13059
Quick View

添加到收藏
DNA topoisomerase II 抑制剂

Beta-Lapachone是一种选择性的DNA拓扑异构酶I抑制剂，对DNA拓扑异构酶II或连接酶没有抑制活性。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Xiaoling Li, .et al. Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H2O2 Generation, ACS Appl. Bio Mater, 2020, 3, 3, 1769-1778
Quick View
AG 957

Catalog No. A13589
Quick View

添加到收藏
p210 tyrosine kinase 抑制剂

AG 957是有效的酪氨酸激酶抑制剂。与p140c-abl（Ki = 10μM）相比，选择性阻断人p210bcr-abl（Ki = 750 nM）的酪氨酸激酶活性。了解更多

Bulk Inquiry
Quick View
JW 55

Catalog No. A13731
Quick View

添加到收藏
TNKS1/2 抑制剂

JW 55是端锚聚合酶1和2（TNKS1/2）的PARP域的抑制剂。了解更多

Bulk Inquiry
Quick View
Erastin

Catalog No. A13822
Quick View

添加到收藏
VDAC 抑制剂

Erastin是一种细胞可渗透的哌嗪基-喹唑啉酮化合物，在具有H-Ras突变的细胞中表现出癌基因选择性致死性。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Yuki Shibata, .et al. Transferrin-based radiolabeled probe predicts the sensitivity of human renal cancer cell lines to ferroptosis inducer erastin, Biochem Biophys Rep, 2021, Feb 24;26 PMID: 33681481
- Shibata Y, .et al. Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo, PLoS One, 2019, Dec 4;14(12):e0225931 PMID: 31800616
Quick View
Resminostat

Catalog No. A12556
Quick View

添加到收藏
HDAC 抑制剂

Resminostat，也称为RAS2410，是一种有效的I和II类组蛋白脱乙酰基酶（HDAC）抑制剂。它结合并抑制HDAC，从而导致高度乙酰化的组蛋白的积累。选择性的抑制HDAC1/3/6，IC50为42.5 nM/50.1 nM/71.8 nM，作用于HDAC8效果弱，IC50为877 nM。了解更多

Bulk Inquiry Free Sample
Quick View
SN 38

Catalog No. A12011
Quick View

添加到收藏
DNA topoisomerase 抑制剂

SN 38是依立替康(喜树碱的类似物-拓扑异构酶I抑制剂)的活性代谢物。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Chen JC, .et al. In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells, Biomolecules, 2019, Sep 9;9(9) PMID: 31505885
- Alibolandi M, .et al. Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38, Artif Cells Nanomed Biotechnol, 2018, May 27:1-12 PMID: 29806500
- Bar-Zeev M, .et al. β-Casein micelles for oral delivery of SN-38 and elacridar to overcome BCRP-mediated multidrug resistance in gastric cancer, Eur J Pharm Biopharm, 2018, Dec;133:240-249 PMID: 30367935
Quick View
Punicalagin

Catalog No. A12105
Quick View

添加到收藏
Carbonic anhydrase 抑制剂

Punicalagin是一种鞣花单宁，一种酚类化合物。它是一种高活性碳酸酐酶抑制剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Elizabeth Read, .et al. Identification of potentially cytotoxic phenolics present in pomegranates (Punica granatum L.), ANIM FEED SCI TECH, 2019, May, 251(187-197)
Quick View
Punicalin

Catalog No. A12106
Quick View

添加到收藏
Carbonic anhydrase 抑制剂

Punicalin是一种高活性碳酸酐酶抑制剂。了解更多

Bulk Inquiry
Quick View
Astragaloside II

Catalog No. A12217
Quick View

添加到收藏
Astragaloside II通过骨形态发生蛋白-2/MAPK和Smad1/5/8途径诱导成骨细胞的成骨活性。了解更多

Bulk Inquiry
Quick View
Tirasemtiv (CK-2017357)

Catalog No. A12568
Quick View

添加到收藏
fast-skeletal-troponin activator

Tirasemtiv (CK-2017357) 是一种快速骨骼肌型肌钙蛋白复合物激活剂。会放大人体对神经激活的骨骼肌反应。了解更多

Bulk Inquiry
Quick View
Ametantrone

Catalog No. A12569
Quick View

添加到收藏
topoisomerase II 抑制剂

Ametantrone (AM)是一种合成的9,10-蒽二酮，在位置1和4上带有两个（羟乙基氨基）乙基氨基残基，以及其他蒽醌和蒽环类化合物。了解更多

Bulk Inquiry
Quick View
Deltarasin HCl

Catalog No. A13722
Quick View

添加到收藏
PDE-KRAS 抑制剂

Deltarasin HCl是一种新型的抑制KRASPDEδ相互作用从而破坏致癌性KRAS信号的小分子。了解更多

Bulk Inquiry Free Sample
Quick View
PSI-6206

Catalog No. A11530
Quick View

添加到收藏
HCV RNA polymerase 抑制剂

PSI-6206是PSI-6130的脱氨基衍生物，是有效的HCV RNA依赖性RNA聚合酶抑制剂，靶向NS5B聚合酶。了解更多

Bulk Inquiry Free Sample
Quick View
NVP-AAM077 Tetrasodium Hydrate (PEAQX)

Catalog No. A14071
Quick View

添加到收藏
NMDA receptors 拮抗剂

NVP-AAM077抑制成年小鼠在脑室下区域和齿状回中的祖细胞增殖，并降低了齿状回中的新生细胞的存活。了解更多

Bulk Inquiry
Quick View
Voreloxin

Catalog No. A14158
Quick View

添加到收藏
Topoisomerase II 抑制剂

Voreloxin是一个小分子，是具有抗肿瘤活性的萘啶类似物。Vosaroxin以位点特异性方式插入DNA中，并阻止拓扑异构酶II在DNA复制过程中进行的重新连接过程。了解更多

Bulk Inquiry
Quick View
Nexturastat A

Catalog No. A14032
Quick View

添加到收藏
HDAC6 抑制剂

Nexturastat A是一种芳基脲衍生物，可作为组蛋白脱乙酰基酶6（HDAC6）的有效且高度选择性的抑制剂（IC50 = 5.02+/-0.60 nM）。了解更多

Bulk Inquiry
Quick View
TAS 103 2HCl

Catalog No. A14141
Quick View

添加到收藏
topoisomerase I/II 抑制剂

TAS 103 2HCl，也称为BMS-247615，是一种喹啉衍生物，在鼠和人肿瘤模型中显示出抗肿瘤活性。了解更多

Bulk Inquiry
Quick View
Meclofenoxate HCl

Catalog No. A14265
Quick View

添加到收藏
cholinephosphotransferase 抑制剂

Meclofenoxate HCl是一种抗衰老药物，用于治疗老年性痴呆和阿尔茨海默氏病的症状，并且还抑制胆碱磷酸转移酶的活性。了解更多

Bulk Inquiry
Quick View
WIKI4

Catalog No. A14283
Quick View

添加到收藏
Tankyrase 抑制剂

WIKI4是一种新型的Tankyrase抑制剂，对TNKS2的IC50为15 nM。了解更多

Bulk Inquiry
Quick View
GSK1265744 (GSK744) Sodium salt

Catalog No. A13984
Quick View

添加到收藏
HIV Integrase 抑制剂

GSK1265744（GSK744）是HIV整合酶的潜在抑制剂，IC50值为3 nM。了解更多

Bulk Inquiry
Quick View
BMH-21

Catalog No. A14335
Quick View

添加到收藏
RNA polymerase 抑制剂

BMH-21是有效的小分子DNA嵌入剂。BMH-21结合核糖体DNA并抑制RNA聚合酶I转录。了解更多

Product Citations (1)

Bulk Inquiry
- Masahiko Okuda, .et al. Three human RNA polymerases interact with TFIIH via a common RPB6 subunit, Nucleic Acids Res, 2021, Jul 16 PMID: 34268577
Quick View
Lupeol

Catalog No. A13951
Quick View

添加到收藏
Lupeol是在某些水果，蔬菜和药用植物中发现的饮食性三萜。它具有有效的抗炎，抗癌，抗诱变和抗疟疾活性。了解更多

Bulk Inquiry Free Sample
Quick View
Doxorubicin

Catalog No. A14403
Quick View

添加到收藏
Topoisomerase II 抑制剂

Doxorubicin是一种抑制DNA拓扑异构酶II并诱导DNA损伤和凋亡的抗生素。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- J Priyanga, .et al. A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells, Chem Biol Interact, 2020, Nov 1;331:109250 PMID: 32956706
- Abdelrehim A, .et al. The use of tail-anchored protein chimeras to enhance liposomal cargo delivery, PLoS One, 2019, Feb 22;14(2):e0212701 PMID: 30794671
- J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
Quick View
DTP348

Catalog No. A14410
Quick View

添加到收藏
CAIX 抑制剂/ radiosensitizer

DTP348是双重CAIX抑制剂/放射增敏剂。了解更多

Bulk Inquiry
Quick View
Nemorubicin

Catalog No. A14363
Quick View

添加到收藏
Topoisomerase II 抑制剂

Nemorubicin是一种抗癌药物，IC50值为0.08 uM。它对抗烷化剂，拓扑异构酶II抑制剂和铂衍生物具有抗性的肿瘤具有活性。它主要通过抑制拓扑异构酶I起作用。了解更多

Bulk Inquiry
Quick View
RG108

Catalog No. A13054
Quick View

添加到收藏
DNA methyltransferase 抑制剂

RG108是DNA甲基转移酶的非核苷抑制剂，IC50为115 nM。了解更多

Bulk Inquiry
Quick View
Atrasentan

Catalog No. A13779
Quick View

添加到收藏
ETA 拮抗剂

Atrasentan是一种实验药物，正在研究中，用于治疗各种类型的癌症，包括非小细胞肺癌。它是对A型亚型（ETA）有选择性的内皮素受体拮抗剂,对ETA的IC50为0.0551 nM。了解更多

Bulk Inquiry
Quick View
Ellipticine

Catalog No. A13780
Quick View

添加到收藏
DNA topoisomerase II 抑制剂

Ellipticine是DNA嵌入剂和DNA拓扑异构酶II抑制剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
Quick View
CKD602

Catalog No. A13656
Quick View

添加到收藏
Topoisomerase I 抑制剂

CKD602是拓扑异构酶I抑制剂。了解更多

Bulk Inquiry
Quick View
5-Bromo Brassinin

Catalog No. A13610
Quick View

添加到收藏
5-Bromo Brassinin是芸苔素的衍生物。了解更多

Bulk Inquiry
Quick View
NK314

Catalog No. A13993
添加到收藏
Topoisomerase II 抑制剂

NK314是一种新型的合成苯并[c]菲啶生物碱，具有很强的抗肿瘤活性。它抑制拓扑异构酶II活性并稳定拓扑异构酶II-DNA可裂解的复合物。了解更多

Product Citations (2)

Bulk Inquiry
- Kopa P, .et al. Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells, Mol Biol Rep, 2019, Oct 3 PMID: 31583565
- Macieja A, .et al. Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors, Mol Biol Rep, 2019, Apr 24 PMID: 31020489
Quick View
BNS-22

Catalog No. A13443
Quick View

添加到收藏
Topo II 抑制剂

BNS-22是Topo II的有效小分子抑制剂（Topo II alpha和Topo II beta的IC50分别为2.8 M和0.42 M）。了解更多

Bulk Inquiry
Quick View
BI207127 (Deleobuvir)

Catalog No. A13414
Quick View

添加到收藏
HCV NS5B polymerase 抑制剂

BI 207127是非核苷类丙型肝炎病毒NS5B聚合酶抑制剂，用于治疗丙型肝炎。了解更多

Bulk Inquiry
Quick View
Crassicauline A

Catalog No. A14615
Quick View

添加到收藏
Crassicauline A提取自乌头乌头。了解更多

Bulk Inquiry
Quick View
(+)-Piresil-4-O-beta-D-glucopyraside

Catalog No. A14643
Quick View

添加到收藏
(+)-Piresil-4-O-beta-D-glucopyraside是在连翘果实中提取。了解更多

Bulk Inquiry

联系我们

Not your Region? View all Distributors

最近查看过的产品

ADOOQ 产品质量保证

Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.