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AMG-510 (Sotorasib)
Catalog No. A19021 KRAS G12C covalent inhibitorAMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. 了解更多 -
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CP-547632 hydrochloride
Catalog No. A22019 VEGFR-2/FGFR inhibitorCP-547632 hydrochloride is a well-tolerated, orally-bioavailable inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases with IC50s of 11 nM and 9 nM, respectively. 了解更多 -
Hydroxystilbamidine bis(methanesulfonate)
Catalog No. A22017 cellular ribonucleases inhibitorHydroxystilbamidine bis(methanesulfonate), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases. 了解更多 -
Eplivanserin
Catalog No. A21967 5-HT2 receptor antagonistEplivanserin is a potent, selective and orally available 5-HT2 receptor antagonist, with an IC50 of 5.8 nM in rat cortical membrane, and a Kd of 1.14 nM. 了解更多 -
Sodium ionophore III
Catalog No. A20813 Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc. 了解更多 -
PF-06840003
Catalog No. A20807 IDO-1 inhibitorPF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively. 了解更多 -
SSR-241586
Catalog No. A20773 neurokinin receptors antagonistSSR-241586 is an antagonist of neurokinin receptors. SSR-241586 is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS). 了解更多 -
Mertansine
Catalog No. A20772 microtubulin inhibitorMertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. 了解更多 -
SB-616234A
Catalog No. A20764 5-HT1B receptor antagonistSB-616234A is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity. 了解更多 -
Naquotinib mesylate
Catalog No. A20762 EGFR inhibitorNaquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR. 了解更多 -
Pumosetrag Hydrochloride
Catalog No. A20692 5-HT3 partial agonistPumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. 了解更多 -
Vipivotide tetraxetan Linker
Catalog No. A20653 Vipivotide tetraxetan Linker (PSMA-617 Linker) is a nonclaevable peptide linker for synthesis of Vipivotide tetraxetan (PSMA-617). 了解更多 -
Azeliragon
Catalog No. A20622 RAGE inhibitorAzeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression in patients with mild Alzheimer??s disease (AD). Azeliragon also can cross the blood-brain barrier (BBB). 了解更多 -
TAK-220
Catalog No. A20618 -
CCT-251921
Catalog No. A20610 CDK8 inhibitorCCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2.3 nM. 了解更多 -
LX2761
Catalog No. A20597 SGLT1/SGLT2 inhibitorLX2761 is chemically stable and potent inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 in vitro with IC50s of 2.2 nM and 2.7nM for hSGLT1 and hSGLT2, but displays specific SGLT1 inhibition in the gastrointestinal (GI) tract. 了解更多 -
PF-01247324
Catalog No. A20596 Nav1.8 channel blockerPF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel. 了解更多 -
JQ-1 (carboxylic acid)
Catalog No. A20579 BRD4 inhibitorJQ-1 carboxylic acid is a highly potent, selective and cell-permeable BRD4 inhibitor with IC50s of 77 nM and 33 nM for BRD4(1) and BRD4(2), respectively. 了解更多 -
SPDP
Catalog No. A20578 short-chain crosslinkerSPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs). 了解更多 -
MC-Val-Cit-PAB
Catalog No. A20571 MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker. 了解更多 -
Futibatinib
Catalog No. A20550 FGFR inhibitorFutibatinib (TAS-120) is an orally bioavailable, highly selective, and irreversible FGFR inhibitor. 了解更多 -
Mal-amido-PEG8-C2-acid
Catalog No. A20548 nonclaevable ADC linkerMal-amido-PEG8-C2-acid (example 142) is a nonclaevable ADC linker, extracted from patent US2018339985. 了解更多 -
Succinic anhydride
Catalog No. A20536 nonclaevable ADC linkerSuccinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide. 了解更多 -
Antihistamine-1
Catalog No. A20515 Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. 了解更多 -
Oxaquin
Catalog No. A20486 Oxaquin (MCB-3837) is a water-soluble, injectable prodrug that is rapidly converted to the active sub-stance MCB3681 in vivo following intravenous (i.v.) administration, active against Gram-positive bacterial species. Oxaquin (MCB-3837) itself has no antimicrobial effects. 了解更多 -
Fumarate hydratase-IN-1
Catalog No. A20471 fumarate hydratase inhibitorFumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM. 了解更多 -
BRCA1-IN-2
Catalog No. A20464 PPI inhibitorBRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions. 了解更多 -
Ralfinamide
Catalog No. A20446 Na+ blockerRalfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain. 了解更多 -
KDM5A-IN-1
Catalog No. A20436 KDM5 inhibitorKDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. 了解更多 -
Tomivosertib
Catalog No. A20407 MNK1/MNK2 inhibitorTomivosertib (eFT508) is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. 了解更多 -
Biotin-VAD-FMK
Catalog No. A20384 caspase inhibitorBiotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates. 了解更多 -
(±)-Zanubrutinib
Catalog No. A20381 Btk inhibitor(±)-Zanubrutinib is a potent, selective and orally available Bruton's tyrosine kinase (Btk) inhibitor. 了解更多
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