Immunology & Inflammation

产品 51 到 100 共 115个

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  1. FK 3311

    Catalog No. A13332
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    COX-2 抑制剂
    FK3311是一种可渗透细胞且可口服的磺酰苯胺,可作为选择性COX-2抑制剂和NSAID。 了解更多
  2. Valdecoxib

    Catalog No. A13342
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    COX-2 抑制剂
    伐地考昔(Valdecoxib),也称为SC-65872,是一种非甾体类抗炎药(NSAID),用于治疗骨关节炎,类风湿性关节炎以及痛经和月经症状。 它是一种选择性的环氧合酶2(COX-2)抑制剂,IC50为5nM。 了解更多
  3. Parecoxib

    Catalog No. A13572
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    COX-2 抑制剂
    Parecoxib是一种有效的选择性COX-2抑制剂。 了解更多
  4. Diflunisal

    Catalog No. A16166
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    COX 抑制剂
    Diflunisal是具有止痛和抗炎活性的水杨酸衍生物。 了解更多
  5. Amfenac Sodium Monohydrate

    Catalog No. A16399
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    COX 抑制剂
    Amfenac Sodium Monohydrate是一种非甾体止痛消炎药,带有乙酸部分。COX1和COX2的IC50值分别为250 nM和150 nM。 了解更多
  6. Ampiroxicam

    Catalog No. A16409
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    COX 抑制剂
    Ampiroxicam是一种非选择性的环氧合酶抑制剂,被用作抗炎药。 了解更多
  7. Carprofen

    Catalog No. A16428
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    COX-2 抑制剂
    Carprofen通过抑制COX-2和其他炎症性前列腺素来减轻炎症,不干扰COX-1活性。 了解更多
  8. Timegadine

    Catalog No. A17108
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    COX and lipo-oxygenase 抑制剂
    Timegadine被发现是一种有效的竞争性环加氧酶(COX)和脂加氧酶抑制剂,IC50的范围从5 nM(洗兔血小板)到20μM(大鼠脑)。在马血小板匀浆的细胞溶质级分和洗涤过的兔血小板中,脂氧化酶的浓度为100μM和100μM。 了解更多
  9. Ketorolac

    Catalog No. A17248
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    COX 抑制剂
    Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. 了解更多
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    Firocoxib

    Catalog No. A17245
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    COX-2 抑制剂
    Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses. 了解更多
  10. Aceclofenac

    Catalog No. A17433
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    COX-2 抑制剂
    Aceclofenac is a cyclooxygenase-2 inhibitor used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. 了解更多
  11. Naproxen

    Catalog No. A17550
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    COX 抑制剂
    Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. 了解更多
  12. Imrecoxib

    Catalog No. A18027
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    COX-2 抑制剂
    Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect. 了解更多
  13. Deracoxib

    Catalog No. A18077
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    NSAID and COX-2 抑制剂
    Deracoxib is an NSAID and COX-2 inhibitor used to treat osteoarthritis. It induces cell cycle arrest and apoptosis in mammary tumor cells, decreases platelet aggregation, and lowers inflammatory responses. 了解更多
  14. Bromfenac sodium hydrate

    Catalog No. A18194
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    COX-2 抑制剂
    Bromfenac Sodium Sesquihydrate is a nonsteroidal anti-inflammatory drug (NSAID), which inhibits cyclooxygenase II (COX-2). 了解更多
  15. Metamizole sodium hydrate

    Catalog No. A18270
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    COX 抑制剂
    Dipyrone, also known as Anador and NSC-73205, is a nonsteroidal anti-inflammatory drug used to treat pain (postoperative, colic, cancer, and migraine). 了解更多
  16. Cenicriviroc

    Catalog No. A13643
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    CCR2/CCR5 抑制剂
    Cenicriviroc是用于治疗HIV感染的实验性候选药物.Cenicriviroc是CCR2和CCR5受体的抑制剂,可使其充当阻止病毒进入人体细胞的进入抑制剂。 了解更多
  17. Aplaviroc

    Catalog No. A13471
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    CCR5 entry 抑制剂
    Aplaviroc是一种CCR5进入抑制剂,用于治疗HIV感染。 了解更多
  18. Cenicriviroc Mesylate

    Catalog No. A17028
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    CCR2/5 receptors 抑制剂
    Cenicriviroc(TAK-652,TBR-652)是CCR2和CCR5受体的抑制剂,可使其充当防止病毒进入人细胞的进入抑制剂 了解更多
  19. ML604086

    Catalog No. A18969
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    CCR8 抑制剂
    ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations. 了解更多
  20. TAK-242 S enantiomer

    Catalog No. A15253
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    TLR4 抑制剂
    TAK-242的S对映体。TAK-242(Resatorvid),Toll样受体(TLR)4信号转导的小分子抑制剂。TAK-242用于治疗败血症和败血性休克。 了解更多
  21. MD2-TLR4-IN-1

    Catalog No. A18452
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    MD2-TLR4 inhibitor
    MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. 了解更多
  22. Resatorvid

    Catalog No. A11543
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    TLR4 inhibitor
    Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor and plays pivotal role in various inflammatory diseases. 了解更多
  23. AN-3485

    Catalog No. A20989
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    TLR inhibitor
    AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM. 了解更多
  24. VGX-1027

    Catalog No. A12548
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    TLR4 抑制剂
    VGX-1027通过抑制Toll样受体4(TLR4)信号传导来显示免疫调节和抗炎活性。 了解更多
  25. TLR2-IN-C29

    Catalog No. A17160
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    TLR 抑制剂
    TLR2-IN-C29是TLR2/1和TLR2/6信号传导的抑制剂。 了解更多
  26. MSX-122

    Catalog No. A12596
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    CXCR4 抑制剂
    MSX-122是口服可生物利用的CXCR4抑制剂(IC50 =?10 nM),具有潜在的抗肿瘤和抗病毒活性。CXCR4抑制剂MSX-122与趋化因子受体CXCR4结合,阻止基质衍生因子-1(SDF-1)与CXCR4受体和受体激活结合,这可能导致肿瘤细胞增殖和迁移减少。 了解更多
  27. Reparixin

    Catalog No. A12383
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    CXCL8/CXCR1/2 抑制剂
    Reparixin是两种CXCL8受体CXCR1/2的有效抑制剂,它抑制CXCR2介导的细胞迁移(IC50 = 100 nM),而它强烈地阻断CXCR1介导的趋化性(IC50 = 1 nM)。 了解更多
  28. Reparixin L-lysine salt

    Catalog No. A15219
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    CXCL8 receptor 抑制剂
    Reparixin L-lysine salt是CXCL8受体的抑制剂,也抑制CXCR1和CXCR2的活化,已显示在各种损伤模型中减弱了炎症反应。 了解更多
  29. Dihydromyricetin (Ampeloptin)

    Catalog No. A10252
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    Dihydropyrimidinase 抑制剂
    Dihydromyricetin (Ampeloptin)是具有良好性能的天然抗氧化剂。 了解更多
  30. Febuxostat (TEI-6720)

    Catalog No. A10382
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    xanthine oxidase 抑制剂
    Febuxostat (TEI-6720)是黄嘌呤氧化酶的非嘌呤抑制剂(Ki = 1.2 nM)。 了解更多
  31. Allopurinol sodium

    Catalog No. A10056
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    xanthine oxidase inhibitor
    Allopurinol sodium是次黄嘌呤(体内天然存在的嘌呤)的结构异构体,是黄嘌呤氧化酶的抑制剂。 了解更多
  32. Asymmetric dimethylarginine

    Catalog No. A18704
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    NOS inhibitor
    Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. 了解更多
  33. L-NIO dihydrochloride

    Catalog No. A13027
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    NOS inhibitor
    L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor. 了解更多
  34. Diphenyleneiodonium chloride

    Catalog No. A13359
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    GPR3 激动剂/NOS/ NADPH oxidases 抑制剂
    Diphenyleneiodonium是一种有效的不可逆的巨噬细胞抑制剂NOS2(iNOS)和内皮细胞NOS3(eNOS)抑制剂。 了解更多
  35. 1400W Dihydrochloride

    Catalog No. A13583
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    INOS 抑制剂
    1400W Dihydrochloride是一种缓慢,紧密结合,有效和高度选择性的诱导型一氧化氮合酶抑制剂(Kd = 7 nM)。对nNOS和eNOS具有选择性(Ki值分别为2和50μM)。细胞可渗透并在体内具有活性。 了解更多
  36. Gw274150

    Catalog No. A12710
    iNOS 抑制剂
    GW274150是有效且高度选择性的iNOS抑制剂,可减少实验性肾脏缺血/再灌注损伤。 了解更多
  37. Nrf2-IN-1

    Catalog No. A12561
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    Nrf2 inhibitor
    Nrf2-IN-1 (Compound 4f) is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2), acts as a promising agent in acute myeloid leukemia (AML) therapy. 了解更多
  38. RTA-408

    Catalog No. A14417
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    Nrf2 抑制剂
    RTA-408是一种合成的三萜类化合物,可有效激活抗氧化转录因子Nrf2并抑制促炎转录因子NF-kB。 了解更多
  39. Brusatol

    Catalog No. A16893
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    Nrf2 抑制剂
    Brusatol是一种生化物质,从Brucea javanica植物中分离出来,可抑制Nrf2。 了解更多
  40. ML-385

    Catalog No. A17172
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    NRF2 抑制剂
    ML-385是核因子红系2相关因子2(Nrf2)的抑制剂,IC50值为1.9μM。 了解更多
  41. MLT-748

    Catalog No. A18954
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    MALT1 inhibitor
    MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. 了解更多
  42. MLT-747

    Catalog No. A18942
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    MALT1 inhibitor
    MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM. 了解更多
  43. MI 2

    Catalog No. A12928
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    MALT1 抑制剂
    MI 2直接与MALT1结合并在体外和体内抑制活化的B细胞样弥漫性大B细胞淋巴瘤(ABC-DLBCL)。 了解更多
  44. PD1-PDL1 inhibitor 2

    Catalog No. A15906
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    PD-1/PD-L1 interaction 抑制剂
    PD1-PDL1 inhibitor 2 是PD-1/PD-L1相互作用抑制剂。 了解更多
  45. PD1-PDL1 inhibitor 1

    Catalog No. A15882
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    PD1-PDL1 inhibitor 1 是PD-1/PD-L1相互作用抑制剂。 了解更多
  46. Apocynin (Acetovanillone)

    Catalog No. A11989
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    NADPH-oxidase 抑制剂
    Apocynin (Acetovanillone)是NADPH氧化酶抑制剂。 了解更多
  47. ML 171

    Catalog No. A13360
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    NOX1 抑制剂
    ML 171是一种有效的、选择性的NADPH-oxidase抑制剂,对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。 了解更多
  48. GKT137831

    Catalog No. A14433
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    NOX1/4 抑制剂
    GKT137831是针对NOX1和NOX4酶的一流抑制剂。 了解更多
  49. APX-115

    Catalog No. A18737
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    Nox inhibitor
    APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury. 了解更多

产品 51 到 100 共 115个

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