“betaine hydrochloride”的搜索结果
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α1 receptor 拮抗剂
Tamsulosin hydrochloride是一种选择性的α1受体拮抗剂,是用于良性前列腺增生的药物。
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Endothelin 拮抗剂 receptor
Atrasentan hydrochloride是一种开发用于治疗前列腺癌的内皮素拮抗剂受体(IC50 = 0.0551 nM,ETA)。
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D1/D5 receptor 拮抗剂
SCH 23390 HCl是一种有效的多巴胺受体拮抗剂(D1和D5受体亚型的Ki值分别为0.2 nM和0.3 nM)。
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5-HT3 receptor 拮抗剂
Azasetron HCl是一种选择性的5-HT3受体拮抗剂,IC50为0.33 nM,用于治疗癌症化学疗法引起的恶心和呕吐。
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dopamine D1/2 receptor antagonist
Melitracen HCl ia potential dopamine D1/2 receptor antagonist used to treat depression. It is often co-administered with flupenthixol as a treatment for trigeminal neuralgia. It does not effect cardiovascular function.
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CGRP Receptor 拮抗剂
MK 3207 hydrochloride是一种有效的CGRP受体拮抗剂,IC50为0.12 nM。
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- Marlene Dallmayer, .et al. Targeting the CALCB/RAMP1-axis inhibits growth of Ewing sarcoma, bioRxiv, 2018, 2018
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CB1 拮抗剂
CP 945598 HCl (Otenabant HCl)是一种有效且高度选择性的CB1拮抗剂。
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H1 histamine receptor 拮抗剂
Clemizole hydrochloride是H1组胺受体的拮抗剂,对NS4B RNA结合的IC50值为8 mM。
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mGlu5 拮抗剂
MTEP hydrochloride是一种有效的,选择性和非竞争性的mGlu5拮抗剂,IC50和Ki分别为5 nM和16 nM。
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OX Receptor 拮抗剂
SB408124 Hydrochloride是OX1受体的非肽拮抗剂,全细胞和膜的Ki分别为57 nM和27 nM。表现出比OX2受体高50倍的选择性。
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5HT3-receptor 拮抗剂
Alosetron Hydrochloride是一种5-羟色胺5HT3受体拮抗剂,可用于治疗肠易激综合症。
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serotonin/histamine2 拮抗剂
Cyproheptadine hydrochloride是抗组胺药,是5-羟色胺和组胺的拮抗剂。
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histamine H1 antagonist
Chlorcyclizine hydrochloride is a histamine H1 antagonist.
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dopamine D2 receptor antagonist
Haloperidol hydrochloride is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
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mGlu5 receptor 拮抗剂
MPEP HCl是对mGlu5a受体亚型(IC50 = 36 nM)的有效,高度选择性的非竞争性拮抗剂,但在浓度高达30 uM的mGlu1b受体上无激动剂或拮抗剂活性。
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5-HT1D receptor 拮抗剂
BRL-15572是一种选择性的h5-HT1D拮抗剂,相对于h5-HT1B表现出60倍的选择性,对一系列其他受体类型的亲和力很小或没有亲和力。
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5-HT1A and α1-adrenergic receptor 拮抗剂
Naftopidil 2HCl是选择性5-HT1A和α1-肾上腺素能受体拮抗剂,IC50分别为0.1μM和0.2μM。
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Dopamine receptor 拮抗剂
cis-(Z)-Flupentixol dihydrochloride是多巴胺受体拮抗剂、抗精神病药物、抗精神病药物。
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5-HT6 拮抗剂
SB 399885 hydrochloride是一种有效的,脑渗透剂和口服活性的SR-6拮抗剂。它对SR-6的选择性比其他血清素受体高200倍(对于人类重组,天然大鼠和天然人类SR-6受体,pKi值分别为9.11、8.81和9.02)。
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α2 adrenergic receptor 拮抗剂
Atipamezole hydrochloride是一种选择性α2肾上腺素受体拮抗剂(α2A、α2B、α2C、α1A和α1B受体的Ki值分别为1.1、1.0、0.89、1300和6500nm)。已经被证明是大脑的渗透剂。
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5-HT6 serotonin receptor 拮抗剂
SB 258585 hydrochloride是一种选择性和有效的SR-6拮抗剂。该化合物显示出比其他5-羟色胺受体亚型高160倍的选择性。
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H3 receptor 拮抗剂
Bavisant dihydrochloride是一种人类H3受体的高选择性,口服活性拮抗剂。
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H3 receptor 拮抗剂
Bavisant dihydrochloride hydrate是人类H3受体的高度选择性口服活性拮抗剂。
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L-isomer of cetirizine and histamine H1 receptor antagonist
Levocetirizine dihydrochloride is a L-isomer of cetirizine and histamine H1 receptor antagonist. It incrases levels of CD4+ CD25+ T cells and decreases levels of eosinophils, decreasing allergy symptoms.
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dopamine D3 receptor antagonist
SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.
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dopamine D2 receptor antagonist
JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder.
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NK1 receptor antagonist
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist.
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5-HT3 receptor 拮抗剂
Granisetron Hydrochloride是血清素5-ht3受体拮抗剂。
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α-adrenergic (AR) 拮抗剂/CaM 抑制剂
Phenoxybenzamine hydrochloride是一种细胞可渗透的,非特异性的,不可逆的α-肾上腺素(AR)拮抗剂,也可作为CaM抑制剂。
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β2 adrenergic 拮抗剂
ICI 118,551 hydrochloride是选择性的β2 adrenergic receptor 拮抗剂,结合 β2,β1 和 β3 肾上腺素能受体的Ki 值分别为 0.7,49.5 和 611 nM。
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Adrenergic α1 Receptor 拮抗剂
HEAT hydrochloride (BE 2254)是一种选择性很强的α1-肾上腺素受体拮抗剂,是3-[125I]-衍生物的前体。肾上腺素受体或肾上腺素能受体是参与多种交感神经系统过程的G蛋白偶联受体。
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α2- adrenoceptor 拮抗剂 / I2 imidazoline receptor 激动剂
Idazoxan hydrochloride 是α2-AR肾上腺素受体拮抗剂和潜在I2咪唑啉受体激动剂。还显示I1咪唑啉受体拮抗剂活性。(I1、I2和α的公钥基础设施值分别为5.90、7.22、8.01、7.43和7.7)。
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CXCR4 拮抗剂
在CXCR4 125I-SDF抑制结合试验中,AMD-070 HCl是一种有效的选择性CXCR4拮抗剂,IC50值为13 nM,抑制T-4型HIV-1(NL4.3株)在MT-4细胞中的复制和PBMC。
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5-HT1F 激动剂
LY 334370 hydrochloride是一种选择性的5-HT1F受体激动剂(Ki值为1.87、16.4,> 100 (IC50))。CAS:199673-74-0(LY 334370盐酸盐);182563-08-2(LY 334370游离碱)
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Dopamine D2 antagonist
Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic.
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μ-opioid receptor (MOR) antagonist
GSK1521498 free base (hydrochloride) is a potent and selective μ-opioid receptor (MOR) antagonist.
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5-HT2/5-HT1 拮抗剂
Mianserin hydrochloride是5-HT2/5-HT1拮抗剂。对5-HT6非选择性5-HT2受体拮抗剂具有中等亲和力。对5-HT6具有中等亲和力。
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5-HT1A receptor 拮抗剂
NAD 299 hydrochloride (Robalzotan)是一种选择性的,高亲和力的5-HT1A受体拮抗剂(体外Ki = 0.6 nM)。
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5-HT1A receptor antagonist
Alprenolol (hydrochloride) is a non-selective beta blocker as well as 5-HT1A receptor antagonist.
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β-adrenergic receptor antagonist
Metipranolol (hydrochloride) is a non-selective β-adrenergic receptor (β-AR) antagonist. Formulations containing metipranolol have been used in the treatment of elevated IOP in patients with ocular hypertension or glaucoma.
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5-HT6 receptor antagonist
SB271046 Hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.
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5-HT (serotonin)/dopamine receptor antagonist
Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
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5-HT2 antagonist
Sarpogrelate hydrochloride (MCI-9042), a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.
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5-HT2C receptor antagonist
SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.
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dopamine D2 receptor antagonist
Risperidone hydrochloride is a serotonin 5-HT2 receptor blocker and a potent dopamine D2 receptor antagonist, with Kis of 0.16, 1.4 nM for 5-HT2 and D2 receptor, respectively.
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5-HT1B receptor antagonist
SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.
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dopamine D2/D3 receptor antagonist
Amisulpride hydrochloride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.
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D3/D2 Dopamine Receptor 拮抗剂
Cariprazine hydrochloride是一种新型的抗精神病药物,对多巴胺D3(Ki = 0.09 nM)和D2(Ki = 0.5 nM)受体具有高选择性和亲和力,对5-羟色胺5-HT(1A)受体具有中等亲和力。
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NK3 receptor 拮抗剂
Talnetant Hydrochloride是一种有效且选择性的NK3受体拮抗剂(ki = 1.4 nM,hNK-3-CHO);对hNK-3受体的选择性是对hNK-2受体的100倍,在浓度高达100 uM时对hNK-1没有亲和力。
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5-HT7 receptor antagonist
SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors.
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