Cell Cycle

产品 201 到 250 共 250个

每页
页面:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

设置升序顺序
  1. KJ Pyr 9

    Catalog No. A16324
    Quick View
    MYC 抑制剂
    KJ Pyr 9是来自Krhnke吡啶库的MYC的新型小分子抑制剂KJ-Pyr-9。 了解更多
  2. ML327

    Catalog No. A17009
    Quick View
    MYC 抑制剂
    ML327是MYC的阻止者。ML327介导E-钙黏着蛋白的转录去阻遏和上皮到间充质转化的抑制。 了解更多
  3. 10074-G5

    Catalog No. A17169
    Quick View
    c-Myc 抑制剂
    10074-G5是c-Myc抑制剂,可抑制c-Myc/Max异二聚体形成并抑制其转录活性,IC50值为146μM。 了解更多
  4. sAJM589

    Catalog No. A18429
    Quick View
    Myc 抑制剂
    sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC50 of 1.8 μM. 了解更多
  5. MK-1775

    Catalog No. A10599
    Quick View
    WEE1 抑制剂
    MK-1775是一种有效的体外和体内Wee1激酶抑制剂。 了解更多
  6. EHT 1864

    Catalog No. A13886
    Quick View
    Rac family GTPase 抑制剂
    EHT 1864是一种抑制Rac家族GTPases的抗增殖化学物质。 了解更多
  7. Zoledronic Acid

    Catalog No. A11010
    Quick View
    osteoclastic bone resorption 抑制剂
    Zoledronic acid, 破骨细胞抑制剂,通过抑制甲羟戊酸途径诱导破骨细胞凋亡。 了解更多
  8. NSC 23766

    Catalog No. A12546
    Quick View
    Rac1 activation 抑制剂
    SC 23766是Rac1-GEF相互作用的选择性抑制剂。通过Rac特异性鸟嘌呤核苷酸交换因子(GEF)TrioN和Tiam1(IC50为50 μM)阻止Rac1激活,而不影响Cdc42或RhoA激活。 了解更多
  9. GGTI-2418

    Catalog No. A13112
    GGTase 抑制剂
    GGTI-2418是香叶基香叶基转移酶I(GGTase I)的合成拟肽抑制剂,它似乎通过下调一些关键的致癌和肿瘤生存途径来诱导凋亡。 了解更多
  10. Balamapimod (MKI-833)

    Catalog No. A13119
    Quick View
    Ras/Raf/MEK 抑制剂
    Balamapimod (MKI-833)是Ras/Raf/MEK抑制剂。 了解更多
  11. ZCL-278

    Catalog No. A13403
    Quick View
    Cdc42 GTPase 抑制剂
    ZCL-278是Cdc42的选择性抑制剂。以Cdc42鸟嘌呤核苷酸交换因子交叉蛋白(ITSN)的结合位点为目标。抑制Cdc42介导的细胞效应,包括3T3成纤维细胞中微峰的形成和初生新生皮质神经元中的神经元分支。还抑制PC3细胞的细胞运动和迁移,无细胞毒性作用。 了解更多
  12. Kobe0065

    Catalog No. A13135
    Quick View
    Ras-Raf interaction 抑制剂
    Kobe0065抑制锚定依赖性和非依赖性生长,阻断MEK / ERK活性并诱导H-rasG12V转化的NIH3T3细胞凋亡。 了解更多
  13. Kobe2602

    Catalog No. A12578
    Quick View
    Ras–Raf 抑制剂
    Kobe2602是Kobe0065的类似物。表现出有效的活性以竞争性抑制Ki-值为149±55 μM的H-Ras·GTP与c-Raf-1 RBD的结合。 了解更多
  14. EHop-016

    Catalog No. A12740
    Quick View
    Rac GTPase Inhibitor
    EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration. 了解更多
  15. K-Ras(G12C) inhibitor 6

    Catalog No. A14103
    Quick View
    K-Ras(G12C) 抑制剂
    K-Ras(G12C) inhibitor 6 是致癌性K-Ras(G12C)的不可逆抑制剂,颠覆了天然核苷酸的偏爱性,使GDP优于GTP。 了解更多
  16. K-Ras(G12C) inhibitor 12

    Catalog No. A14227
    Quick View
    K-Ras(G12C) 抑制剂
    K-Ras(G12C) inhibitor 12 是致癌性K-Ras(G12C)的变构抑制剂。 了解更多
  17. 6H05 (trifluoroacetate salt)

    Catalog No. A14235
    Quick View
    K-Ras 抑制剂
    6H05 (trifluoroacetate salt)是致癌性K-Ras(G12C)的选择性变构抑制剂。 了解更多
  18. K-Ras(G12C) inhibitor 9

    Catalog No. A14250
    Quick View
    K-Ras(G12C) 抑制剂
    K-Ras(G12C) inhibitor 9是致癌性K-Ras(G12C)的变构抑制剂。 了解更多
  19. NSC-23766 HCl

    Catalog No. A13975
    Quick View
    Rac GTPase 抑制剂
    NSC 23766是Rac特异性GEF TrioN和Tiam 1(IC50 = 50 uM)引起的Rac1激活的细胞可渗透性可逆抑制剂。 了解更多
  20. CCG-1423

    Catalog No. A14430
    Quick View
    Rho 抑制剂
    CCG-1423是Rho途径介导的信号传导和血清反应因子(SRF)转录激活的特异性抑制剂。 了解更多
  21. Salirasib

    Catalog No. A11572
    Quick View
    PPMTase 抑制剂
    Salirasib是Prenylated蛋白甲基转移酶(PPMTase)的抑制剂,Ki值为2.6 uM。 了解更多
  22. XRP44X

    Catalog No. A16049
    Quick View
    Ras-Net 抑制剂
    XRP44X是Ras-Net(Elk-3)途径抑制剂(IC50 = 10-20 nM)。间接抑制Erk1/2激活上游的净磷酸化。 了解更多
  23. 6H05

    Catalog No. A16097
    Quick View
    K-Ras 抑制剂
    6H05是致癌突变体K-Ras(G12C)的选择性变构抑制剂。 了解更多
  24. APS-2-79 HCl

    Catalog No. A16175
    Quick View
    KSR/Ras 抑制剂
    APS-2-79 HCl,稳定KSR(Ras激酶抑制剂)失活状态并拮抗致癌性Ras信号(IC50值为120 nM,对抗KSR2的ATP-生物素探针标记)的小分子。 了解更多
  25. APS-2-79

    Catalog No. A16231
    Quick View
    KSR/Ras 抑制剂
    APS-2-79是RAF通过直接结合KSR活性位点而使MEK磷酸化的拮抗剂。 了解更多
  26. BQU57

    Catalog No. A14956
    Quick View
    GTPase Ral 抑制剂
    BQU57是RBC8的衍生物,是相对于GTPases Ras和RhoA的选择性GTPase Ral抑制剂。 了解更多
  27. ARS-1620

    Catalog No. A16809
    Quick View
    KRAS-G12C 抑制剂
    ARS-1620是一种有效的口服生物利用性共价抑制剂(KRAS-G12C),可以实现体内靶标的快速,持续存在,从而诱导肿瘤消退。 了解更多
  28. BDP9066

    Catalog No. A16874
    Quick View
    MRCK 抑制剂
    BDP9066是有效的选择性MRCK抑制剂,可减少底物的磷酸化。 了解更多
  29. ARS-1630

    Catalog No. A17061
    Quick View
    mutant K-ras G12C 抑制剂
    ARS-1630是突变K-ras G12C的新型抑制剂。 了解更多
  30. ARS-1323

    Catalog No. A17060
    Quick View
    mutant K-ras G12C 抑制剂
    ARS-1323是突变K-ras G12C的新型抑制剂。 了解更多
  31. Antineoplaston A10

    Catalog No. A17183
    Quick View
    Ras 抑制剂
    Antineoplaston A 10是Ras抑制剂,可能用于治疗神经胶质瘤,淋巴瘤,星形细胞瘤和乳腺癌。 了解更多
    • 最新产品

    MRTX1257

    Catalog No. A17223
    Quick View
    KRAS-G12C inhibitor
    MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM. 了解更多
    • 最新产品

    Ras-IN-3144

    Catalog No. A17222
    Quick View
    pan-RAS inhibitor
    Ras-IN-3144 is a pan-RAS inhibitor which inhibits RAS signaling pathways in cancer cells and prevents the growth of RAS mutant mouse cancer xenografts. 了解更多
  32. AMG-510 racemate

    Catalog No. A18752
    Quick View
    KRAS G12C covalent inhibitor
    AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. 了解更多
  33. ZT-12-037-01

    Catalog No. A18395
    Quick View
    ATP-competitive STK19 inhibitor
    ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor. ZT-12-037-01 effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo. 了解更多
  34. KRAS G12C inhibitor 13

    Catalog No. A19041
    Quick View
    KRAS G12C inhibitor
    KRAS G12C inhibitor 13 is a KRAS G12C inhibitor extracted from patent WO2018143315A1, compound 30. 了解更多
  35. KRAS G12C inhibitor 5

    Catalog No. A18840
    Quick View
    KRas G12C inhibitor
    KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147. 了解更多
  36. KRAS G12C inhibitor 15

    Catalog No. A18447
    Quick View
    KRAS G12C inhibitor
    KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM. 了解更多
  37. KRAS G12C inhibitor 16

    Catalog No. A18444
    Quick View
    KRAS G12C inhibitor
    KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM. 了解更多
  38. KRAS G12C inhibitor 17

    Catalog No. A18441
    Quick View
    KRAS G12C inhibitor
    KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM. 了解更多
  39. EHT 5372

    Catalog No. A12586
    Quick View
    DYRK inhibitor
    EHT 5372 is a strong inhibitor of DYRK??s family kinases, with IC50s of 0.22, 0.28 nM for DYRK1A and DYRK1B, respectively. 了解更多
  40. LDN-192960 hydrochloride

    Catalog No. A21390
    Quick View
    DYRK2 inhibitor
    LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively. 了解更多
  41. ID 8

    Catalog No. A12922
    Quick View
    DYRK 抑制剂
    ID-8是DYRK抑制剂。ID 8还以稳定的速率刺激增殖(在30天的补充有10 μM的无血清培养基中观察到)。 了解更多
  42. AZ191

    Catalog No. A14314
    Quick View
    DYRK 抑制剂
    AZ191是一种有效的选择性DYRK1B抑制剂,IC50为17 nM,选择性比DYRK1A和DYRK2高5到110倍。 了解更多
  43. Mirk-IN-1

    Catalog No. A16255
    Quick View
    Dyrk1B 抑制剂
    Mirk-IN-1是有效的Dyrk1B(Mirk kianse)和Dyrk1A抑制剂,IC50分别为68±48 nM和22±8 nM。 了解更多
  44. 360A

    Catalog No. A14975
    Quick View
    G-quadruplex structures 抑制剂
    360A是G四联体结构的强亲和力和选择性抑制剂。 了解更多
  45. 360A iodide

    Catalog No. A14976
    Quick View
    G-quadruplex structures 抑制剂
    360A iodide是G-四链结构的强亲和选择性抑制剂。 了解更多
  46. RI-1

    Catalog No. A13187
    Quick View
    RAD51 抑制剂 II
    RI-1是抑制中央重组蛋白RAD51的小分子。RI-1在刺激单链退火的同时特别减少了人类细胞中的基因转化。RI-1与半胱氨酸319处的RAD51蛋白表面共价结合,这可能会使RAD51单体寡聚化成DNA上的细丝所用的界面不稳定。 了解更多
  47. RAD51 Inhibitor B02

    Catalog No. A18334
    Quick View
    RAD51 inhibitor
    AD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. 了解更多
  48. RI-2

    Catalog No. A20992
    Quick View
    RAD51 inhibitor
    RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells. 了解更多

产品 201 到 250 共 250个

每页
页面:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

设置升序顺序
Rewards