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Epigenetics

产品 151 到 200 共 474个

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  1. GW841819X
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    GW841819X

    Catalog No. A16367
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    BET 抑制剂
    GW841819X是(+)-JQ1的类似物，是BET溴结构域的新型抑制剂。GW841819X是单个对映异构体，但在苯并二氮杂3.环3的4位具有不确定的手性。 了解更多
  2. BET-BAY 002
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    BET-BAY 002

    Catalog No. A16368
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    BET 抑制剂
    BET-BAY 002是一种有效的BET抑制剂，对多发性骨髓瘤模型有效。 了解更多
  3. CPI-637
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    CPI-637

    Catalog No. A16470
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    CBP/EP300 bromodomain 抑制剂
    CPI-637是一种选择性的，具有细胞活性的苯并二氮杂酮CBP/EP300溴结构域抑制剂。 了解更多
  4. ZL0420
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    ZL0420

    Catalog No. A16829
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    BRD4 抑制剂
    ZL0420是一种有效的选择性BRD4抑制剂，对BRD4 BD1的IC50值分别为27 nM，对BRD4 BD2的IC50值比相关BRD2同系物的选择性高。 了解更多
  5. A-485
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    A-485

    Catalog No. A16830
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    p300/CBP 抑制剂
    A-485是p300/CBP的强效选择性HAT抑制剂，在p300 TR-FRET分析中的IC50为10 nM，在CBP TR-FRET分析中的IC50为3 nM，选择性是紧密相关的HAT的1000倍以上。 了解更多
  6. ABBV-744
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    ABBV-744

    Catalog No. A16831
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    BET bromodomain 抑制剂
    ABBV-744是一种BDII选择性BET溴结构域抑制剂，正在研究中，用于治疗AML和对去势抵抗的前列腺癌。 了解更多
  7. BAY1238097
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    BAY1238097

    Catalog No. A16881
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    BET 抑制剂
    BAY1238097是一种有效的选择性BET抑制剂。BAY1238097与BET蛋白BRD上的乙酰化赖氨酸识别基序结合，从而防止BET蛋白与组蛋白之间的相互作用。 了解更多
  8. HJB-97
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    HJB-97

    Catalog No. A16872
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    BET bromodomian 抑制剂
    HJB-97是一种有效的BET溴甲烷抑制剂。它以BRD2/3/4 BD1和BD2为目标。 了解更多
  9. ARV-825
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    ARV-825

    Catalog No. A16859
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    BRD4 抑制剂
    ARV-825是一种异质双功能分子，由BRD4结合部分与E3连接酶脑结合部分组成，采用蛋白水解靶向嵌合体（PROTAC）技术连接。 了解更多
  10. TP-472
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    TP-472

    Catalog No. A17180
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    BRD9/7 抑制剂
    TP-472是有效的BRD9/7抑制剂，Kd分别为33和340 nM。 了解更多
  11. CF53
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    CF53

    Catalog No. A17175
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    BET 抑制剂
    CF53是一种溴结构域和末端（BET）溴结构域抑制剂，IC50值为11.7 nM。 了解更多
  12. PLX51107
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    PLX51107

    Catalog No. A18345
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    selective BET inhibitor
    PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1, and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively; PLX51107 also interacts with the bromodomains of CBP and EP300 (Kd, in the 100 nM range). 了解更多
  13. Mivebresib (ABBV-075)
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    • 最新产品

    Mivebresib (ABBV-075)

    Catalog No. A17226
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    BET inhibitor
    Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity. 了解更多
  14. MS402
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    MS402

    Catalog No. A18866
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    BRD inhibitor
    MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. 了解更多
  15. GNE-207
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    GNE-207

    Catalog No. A18844
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    CBP bromodomain inhibitor
    GNE-207 is a novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP. GNE-207 has excellent CBP potency (CBP IC50?=?1?nM, MYC EC50?=?18?nM), and it exhibits a good pharmacokinetic profile. 了解更多
  16. P300/CBP-IN-3
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    P300/CBP-IN-3

    Catalog No. A18544
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    p300/CBP histone acetyltransferase inhibitor
    P300/CBP-IN-3, a p300/CBP histone acetyltransferase inhibitor. 了解更多
  17. BRD-IN-3
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    BRD-IN-3

    Catalog No. A18454
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    BRD inhibitor
    BRD-IN-3 ((R,R)-36n) is a highly potent PCAF bromodomain (BRD) inhibitor, with an IC50 of 7 nM. BRD-IN-3 also exhibits activity against GCN5 and FALZ. 了解更多
  18. GNE-049
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    GNE-049

    Catalog No. A20206
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    CBP inhibitor
    GNE-049 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively. 了解更多
  19. ZEN-3219
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    ZEN-3219

    Catalog No. A19367
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    BET inhibitor
    ZEN-3219 is a BET inhibitor with IC50s of 0.48, 0.16 and 0.47 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation of BRD4. 了解更多
  20. TPOP146
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    TPOP146

    Catalog No. A12655
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    CBP/P300 benzoxazepine bromodomain inhibitor
    TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. 了解更多
  21. GSK 1210151A (I-BET151)
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    GSK 1210151A (I-BET151)

    Catalog No. A11783
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    BET Bromodomain 抑制剂
    GSK 1210151A (I-BET151)是溴结构域和额外末端（BET）家族蛋白BRD2，BRD3和BRD4的新型选择性抑制剂。 了解更多
  22. PFI-1
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    PFI-1

    Catalog No. A12545
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    BET 抑制剂
    PFI-1是BET溴结构域抑制剂，对BRD2和BRD4表现出抑制活性。 了解更多
  23. GSK 525762A (I-BET-762)
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    GSK 525762A (I-BET-762)

    Catalog No. A11440
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    BET 抑制剂
    GSK 525762A (I-BET-762)是BET(溴域和末端外)家族的小分子抑制剂。 了解更多
  24. CPI-203
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    CPI-203

    Catalog No. A13068
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    BET bromodomain 抑制剂
    CPI203是溴结构域和额外末端（BET）家族蛋白BRD4的新型有效，选择性和细胞渗透性抑制剂，IC50为?37 nM（BRD4α筛选试验）。 了解更多
  25. Bromosporine
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    Bromosporine

    Catalog No. A13163
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    bromodomain 抑制剂
    Bromosporine是一种针对溴结构域的广谱抑制剂，对于BRD2，BRD4，BRD9和CECR2的IC50分别为0.41μM，0.29μM，0.122μM和0.017μM。 了解更多
  26. UNC 669
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    UNC 669

    Catalog No. A13717
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    L3MBTL 抑制剂
    UNC669是L3MBTL1和L3MBTL3的抑制剂,对L3MBTL1和L3MBTL3具有选择性（IC50分别为4.2μM和3.1μM）。 了解更多
  27. (+)-JQ1
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    (+)-JQ1

    Catalog No. A12729
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    BET 抑制剂
    (+)-JQ1是有效的，高亲和力的选择性BET溴结构域抑制剂。 了解更多
  28. SGC-CBP30
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    SGC-CBP30

    Catalog No. A13227
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    CBP/p300 bromodomain 抑制剂
    SGC-CBP30是一种有效且选择性的CREBBP（CBP）和EP300抑制剂，无细胞试验中IC50分别为21 nM和38 nM。它们是一般的转录共激活因子。 了解更多
  29. OTX015
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    OTX015

    Catalog No. A13890
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    BET 抑制剂
    OTX015是口服可生物利用的BRD2，BRD3和BRD4的小分子抑制剂（EC50s = 10-19 nM）。 了解更多
  30. UNC1215
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    UNC1215

    Catalog No. A12948
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    L3MBTL3 抑制剂
    UNC1215是具有细胞活性的L3MBTL3的强效选择性拮抗剂。 了解更多
  31. I-CBP112
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    I-CBP112

    Catalog No. A13165
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    CBP/p300 bromodomain 抑制剂
    I-CBP112是一种高效且选择性的p300/CBP溴结构域抑制剂（对于CBP，IC50为?0.14-0.17 uM，对于p300为?0.625 uM）。 了解更多
  32. MS436
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    MS436

    Catalog No. A13749
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    BRD4 抑制剂
    MS436是用于BRD4溴结构域的重氮基小分子抑制剂，Ki值为30-50 nM。 了解更多
  33. I-BRD9
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    I-BRD9

    Catalog No. A15872
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    Selective BRD9 抑制剂
    I-BRD9是一种有效的选择性BRD9抑制剂，pIC50为7.3，而对BRD4的pIC50为5.3。 了解更多
  34. BI-7273
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    BI-7273

    Catalog No. A16068
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    BRD9 BD 抑制剂
    BI-7273是一种选择性的，细胞可渗透的BRD9 BD抑制剂。 了解更多
  35. BI-9564
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    BI-9564

    Catalog No. A16196
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    BRD7/9 抑制剂
    BI-9564是BRD9和BRD7溴结构域的有效和选择性抑制剂（Kds分别为14.1和239 nM；IC50分别为75 nM和3.4 uM）。 了解更多
  36. (E)-ZL0420
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    (E)-ZL0420

    Catalog No. A20136
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    BRD4 inhibitor
    ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2. 了解更多
  37. ZL0454
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    ZL0454

    Catalog No. A20123
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    BRD4 inhibitor
    ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2. 了解更多
  38. BMS-986158
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    BMS-986158

    Catalog No. A19442
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    Bromodomain inhibitor
    BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins. 了解更多
  39. MS417
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    MS417

    Catalog No. A19433
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    BRD4 inhibitor
    MS417 is a BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM). 了解更多
  40. CD235
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    CD235

    Catalog No. A19115
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    BET bromodomain inhibitor
    CD235 is a structurally similar analogue of CD161. CD161 is a potent and orally bioavailable BET bromodomain inhibitor. 了解更多
  41. BETd-246
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    BETd-246

    Catalog No. A18913
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    BRD inhibitor
    BETd-246 is a second-generation BET bromodomain (BRD) inhibitor, exhibiting superior selectivity, potency and antitumor activity. 了解更多
  42. Bromodomain IN-1
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    Bromodomain IN-1

    Catalog No. A18845
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    Bromodomain inhibitor
    Bromodomain IN-1 is a Bromodomain inhibitor extracted from patent WO2016069578A1, compound 4 . 了解更多
  43. BRD4 Inhibitor-10
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    BRD4 Inhibitor-10

    Catalog No. A18679
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    BRD4-BD1 inhibitor
    BRD4 Inhibitor-10 is a potent BRD4-BD1 inhibitor extracted from patent WO2015022332A1, Compound II-25, has an IC50 of 8 nM. 了解更多
  44. GSK9311
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    GSK9311

    Catalog No. A12453
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    inhibitor of the BRPF bromodomain
    GSK9311 is a potent inhibitor of the BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively. 了解更多
  45. BET-IN-1
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    BET-IN-1

    Catalog No. A12141
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    bromodomain inhibitor
    BET-IN-1 is a bromodomain inhibitor extracted from patent WO/2013024104A1, compound example 2, has a plC50 in the range 6.0 - 7.0. IC50 value: 6.0 - 7.0 (plC50) Target: bromodomain 了解更多
  46. GS-626510
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    GS-626510

    Catalog No. A13305
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    BET family bromodomains inhibitor
    GS-626510 is a potent, and orally bioavailable BET family bromodomains inhibitor, with Kd values of 0.59-3.2 nM for BRD2/3/4, with IC50 values of 83 nM and 78 nM foe BD1 and BD2, respectively. 了解更多
  47. (Rac)-BAY1238097
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    (Rac)-BAY1238097

    Catalog No. A21598
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    BET inhibitor
    (Rac)-BAY1238097 is a BET inhibitor, with an IC50 of 1.02 μM for BRD4. Used in cancer research. 了解更多
  48. INCB054329 Racemate
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    INCB054329 Racemate

    Catalog No. A21609
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    BET protein inhibitor
    INCB054329 Racemate is a BET protein inhibitor. 了解更多
  49. CPI-0610 carboxylic acid
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    CPI-0610 carboxylic acid

    Catalog No. A21714
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    BET inhibitor
    CPI-0610 carboxylic acid is a potent bromodomain and extra-terminal (BET) protein inhibitor. CPI-0610 carboxylic acid has the potential in the therapy of multiple myeloma. 了解更多
  50. AZD5153 6-Hydroxy-2-naphthoic acid
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    AZD5153 6-Hydroxy-2-naphthoic acid

    Catalog No. A21852
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    BET/BRD4 bromodomain inhibitor
    AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM. 了解更多

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