Topoisomerase

Catalog No.Inhibitor Name TopoisomeraseTopo ITopo IITopo IVOther
A10174Camptothecin
**
A10939Topotecan HCl
****
A10465Idarubicin HCl
***
Multicellular spheroids
A10194Daunorubicin HCl
***
A11999Betulinic acid
**
HIV-1,Aminopeptidase N
A11861Flumequine
*
A14403Doxorubicin
A10373Etoposide
A10478Irinotecan
A10345Epirubicin HCl
A10596Mitoxantrone HCl
A10609Moxifloxacin HCl
A10479Irinotecan HCl Trihydrate
A12011SN-38
A10071Amonafide
A10907Teniposide
A10419Gatifloxacin
A10426Genistein
EGFR
A10595Mitoxantrone
A10735Pirarubicin
A10041Adriamycin
A10557Marbofloxacin
A10666Ofloxacin
A10740Podophyllotoxin
A12663Amrubicin
A13059Beta-Lapachone
IDO1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 61个

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  1. Amrubicin

    Catalog No. A12663
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    Topoisomerase II 抑制剂
    Amrubicin是一种合成的蒽环类抗生素。它抑制DNA拓扑异构酶II。 了解更多
  2. Gimatecan

    Catalog No. A12856
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    topoisomerase I 抑制剂
    Gimatecan是喜树碱的一种口服生物可利用的,半合成的亲脂类似物,喜树碱是一种从亚洲喜树树中提取的喹啉生物碱,具有潜在的抗肿瘤和抗血管生成活性。 了解更多
  3. Gatifloxacin

    Catalog No. A10419
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    DNA gyrase/topoisomerase IV 抑制剂
    Gatifloxacin是一种氟喹诺酮类抗生素,可抑制细菌dna回旋酶(IC50 = 0.109 ng/ml)和拓扑异构酶iv(IC50 = 13.8 ng/ml)。 了解更多
  4. Ofloxacin (DL8280)

    Catalog No. A10666
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    Topoisomerase 抑制剂
    Ofloxacin (DL8280)是一种合成的广谱抗菌剂。 了解更多
  5. Ametantrone

    Catalog No. A12569
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    topoisomerase II 抑制剂
    Ametantrone (AM)是一种合成的9,10-蒽二酮,在位置1和4上带有两个(羟乙基氨基)乙基氨基残基,以及其他蒽醌和蒽环类化合物。 了解更多
  6. Voreloxin

    Catalog No. A14158
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    Topoisomerase II 抑制剂
    Voreloxin是一个小分子,是具有抗肿瘤活性的萘啶类似物。Vosaroxin以位点特异性方式插入DNA中,并阻止拓扑异构酶II在DNA复制过程中进行的重新连接过程。 了解更多
  7. TAS 103 2HCl

    Catalog No. A14141
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    topoisomerase I/II 抑制剂
    TAS 103 2HCl,也称为BMS-247615,是一种喹啉衍生物,在鼠和人肿瘤模型中显示出抗肿瘤活性。 了解更多
  8. Nemorubicin

    Catalog No. A14363
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    Topoisomerase II 抑制剂
    Nemorubicin是一种抗癌药物,IC50值为0.08 uM。它对抗烷化剂,拓扑异构酶II抑制剂和铂衍生物具有抗性的肿瘤具有活性。它主要通过抑制拓扑异构酶I起作用。 了解更多
  9. CKD602

    Catalog No. A13656
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    Topoisomerase I 抑制剂
    CKD602是拓扑异构酶I抑制剂。 了解更多
  10. BNS-22

    Catalog No. A13443
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    Topo II 抑制剂
    BNS-22是Topo II的有效小分子抑制剂(Topo II alpha和Topo II beta的IC50分别为2.8 M和0.42 M)。 了解更多
  11. Voreloxin Hydrochloride

    Catalog No. A15280
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    Topoisomerase 抑制剂
    Voreloxin hydrochloride是一种小分子,是具有抗肿瘤活性的萘啶类似物;Topo II抑制剂。 了解更多
  12. Clorobiocin

    Catalog No. A15467
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    DNA Gyrase 抑制剂
    Clorobiocin是一种氨基香豆素。 了解更多
  13. SW044248

    Catalog No. A15837
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    TOP1 抑制剂?
    SW044248是一种新型的非规范性Top1抑制剂,对NSCLC细胞具有选择性毒性。 了解更多
  14. Levofloxacin hydrate

    Catalog No. A16167
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    topoisomerase II IV 抑制剂
    Levofloxacin hydrate是广谱的第三代氟喹诺酮类抗生素,是具有抗菌活性的氧氟沙星的旋光性L-异构体。 了解更多
  15. Clinafloxacin

    Catalog No. A16458
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    DNA gyrase and topoisomerase IV 抑制剂
    Clinafloxacin是一种氟喹诺酮,可双重抑制肺炎链球菌中的DNA促旋酶和拓扑异构酶IV。 了解更多
  16. Pixantrone

    Catalog No. A13022
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    Topoisomerase II 抑制剂
    Pixantrone是一种拓扑异构酶II抑制剂和DNA嵌入剂,具有抗肿瘤活性。 了解更多
  17. Topotecan

    Catalog No. A16815
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    Topoisomerase 抑制剂
    Topotecan是用于治疗卵巢癌的抗肿瘤药,可通过抑制DNA拓扑异构酶起作用。 了解更多
  18. CL2-SN-38

    Catalog No. A18945
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    DNA topoisomerase I inhibitor
    CL2-SN-38 is a part of the antibody drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is a DNA topoisomerase I inhibitor. 了解更多
  19. MAC glucuronide α-hydroxy lactone-linked SN-38

    Catalog No. A18407
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    Topoisomerase I inhibitor
    MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. 了解更多
  20. Top1 inhibitor 1

    Catalog No. A13304
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    human topoisomerase I (Top1) inhibitor
    Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM. 了解更多
  21. Indotecan

    Catalog No. A20979
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    Top1 inhibitor
    Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. 了解更多
  22. Norfloxacin (Norxacin)

    Catalog No. A10652
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    Topoisomerase 抑制剂
    Norfloxacin(Norxacin)是一种广谱抗生素。 了解更多
  23. Marbofloxacin

    Catalog No. A10557
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    Topoisomerase 抑制剂
    Marbofloxacin是有效的第三代氟喹诺酮类抗生素,通过抑制细菌DNA复制起作用。 了解更多
  24. Topotecan HCl (Hycamtin)

    Catalog No. A10939
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    DNA topoisomerase I 抑制剂
    Topotecan HCl (Hycamtin)是一种化学治疗剂,是拓扑异构酶抑制剂。 了解更多
  25. Irinotecan HCl Trihydrate (Campto)

    Catalog No. A10479
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    Topoisomerase 抑制剂
    Irinotecan (CPT 11)是喜树碱家族的一种化合物,是参与细胞DNA复制和转录的拓扑异构酶1的抑制剂。 了解更多
  26. Adriamycin

    Catalog No. A10041
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    topoisomerase II 抑制剂
    Adriamycin是一种蒽环类抗生素,它通过插入DNA起作用,而最严重的副作用是危及生命的心脏损害。它通常用于治疗多种癌症,包括血液系统恶性肿瘤,多种类型的癌症和软组织肉瘤。 了解更多
  27. Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

    Catalog No. A10194
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    Topoisomerase 抑制剂
    Cerubidine (Daunorubicin HCl,Rubidomycin HCl)通过插入和抑制大分子生物合成与DNA相互作用。这抑制了拓扑异构酶II的进程,该酶使DNA中的超螺旋松弛以进行转录。 了解更多
  28. Exatecan

    Catalog No. A11231
    Topoisomerase I 抑制剂
    Exatecan mesylate可通过稳定拓扑异构酶I与DNA之间的可裂解复合物并抑制DNA断裂的连接来抑制拓扑异构酶I的活性,从而抑制DNA复制并触发凋亡性细胞死亡。 了解更多
  29. Camptothecin

    Catalog No. A10174
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    Topoisomerase I 抑制剂
    Camptothecin是一种细胞毒性喹啉生物碱,可抑制DNA酶拓扑异构酶I(拓扑I)。 了解更多
  30. Epirubicin HCl

    Catalog No. A10345
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    Topoisomerase II 抑制剂
    Epirubicin HCl是一种可透过细胞的蒽环类抗肿瘤抗生素。它用于抑制拓扑异构酶II和DNA解旋酶活性。 了解更多
  31. Balofloxacin

    Catalog No. A11658
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    Topoisomerase 抑制剂
    Balofloxacin是一种喹诺酮类抗生素。Balofloxacin的杀菌作用源于对细菌DNA合成所需的酶DNA促旋酶的干扰。Balofloxacin对革兰氏阴性菌有效。它还对革兰氏阳性细菌(包括MRSA和肺炎链球菌)具有增强的活性。 了解更多
  32. Sarafloxacin HCl

    Catalog No. A11659
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    Topoisomerase 抑制剂
    Sarafloxacin hydrochloride是氟喹诺酮类抗菌剂。抑制细菌DNA促旋酶(拓扑异构酶)。 了解更多
  33. Flumequine

    Catalog No. A11861
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    Topoisomerase II 抑制剂
    Flumequine是一种合成化学抗生素,可在回旋酶/拓扑异构酶水平上影响哺乳动物染色体和DNA的解链。抑制拓扑异构酶II, IC50为15 μM。 了解更多
  34. Pirarubicin

    Catalog No. A10735
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    Topoisomerase II 抑制剂
    Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II(拓扑异构酶II)相互作用并抑制DNA复制。 了解更多
  35. (S)-10-Hydroxycamptothecin

    Catalog No. A11997
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    Topoisomerase
    (S)-10-Hydroxycamptothecin是喜树碱衍生物,它通过在染色体DNA中产生链断裂并诱导细胞凋亡来抑制DNA拓扑异构酶。 了解更多
  36. Amsacrine hydrochloride

    Catalog No. A17707
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    antineoplastic agent
    Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells. 了解更多
  37. Pirarubicin Hydrochloride

    Catalog No. A18037
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    topoisomerase II inhibitor
    Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors. 了解更多
  38. Gepotidacin

    Catalog No. A21086
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    topoisomerase II inhibitor
    Gepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. 了解更多
  39. Namitecan

    Catalog No. A21146
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    topoisomerase I inhibitor
    Namitecan is a potent topoisomerase I inhibitor, with antitumor property. 了解更多
  40. Karenitecin

    Catalog No. A21156
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    topoisomerase I inhibitor
    Karenitecin (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity. 了解更多
  41. Edotecarin

    Catalog No. A21233
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    Topoisomerase I inhibitor
    Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM. 了解更多
  42. Exatecan Mesylate

    Catalog No. A21515
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    DNA topoisomerase I inhibitor
    Exatecan Mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. 了解更多
  43. Dxd

    Catalog No. A21517
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    DNA topoisomerase I inhibitor
    Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). 了解更多
  44. Daun02

    Catalog No. A21818
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    prodrug of the topoisomerase inhibitor Daunorubicin
    Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin. 了解更多
  45. Daunorubicin

    Catalog No. A21903
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    topoisomerase II inhibitor
    Daunorubicin (Daunomycin; RP 13057; Rubidomycin) is a topoisomerase II inhibitor with potent antineoplastic activities. 了解更多
  46. TAS-103

    Catalog No. A21954
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    DNA topoisomerase I/II inhibitor
    TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. 了解更多
  47. Moxifloxacin HCl

    Catalog No. A10609
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    Topoisomerase 抑制剂
    Moxifloxacin HCl是一种喹诺酮/氟喹诺酮类抗菌剂。 了解更多
  48. 9-amino-CPT

    Catalog No. A12540
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    Topoisomerase I inhibitor
    9-Aminocamptothecin is a topoisomerase I inhibitor with potent anticancer activity. 了解更多
  49. Epirubicin

    Catalog No. A12409
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    Topoisomerase 抑制剂
    Epirubicin是一种细胞可渗透的抗肿瘤抗生素。阿霉素的立体异构体,其心脏毒性降低。表柔比星的抗肿瘤作用是通过靶向和抑制Topo II(拓扑异构酶II)来介导的。 了解更多
  50. MAC glucuronide phenol-linked SN-38

    Catalog No. A18403
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    DNA topoisomerase I inhibitor
    MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively. 了解更多

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