Bcr-Abl

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Bcr-Abl	Abl	Other
A10290	Dasatinib	****	****	Src,c-Kit (D816V),c-Kit (wt)
A10468	Imatinib Mesylate		*	c-Kit,PDGFR
A10108	Saracatinib		**	c-Src,LCK,EGFR (L861Q)
A10080	Ponatinib	****	****	PDGFRα,VEGFR2,FGFR1
A10644	Nilotinib	**
A10715	Danusertib	**	**	Aurora A,TrkA,RET
A10095	AT9283		***	JAK3,JAK2,Aurora B
A10988	Degrasyn	*		DUB
A10119	Bafetinib	***	***	Lyn
A10508	KW-2449	**	***	FLT3 (D835Y),FLT3,FGFR1
A10661	NVP-BHG712		*	EphB4,C-Raf,c-Src
A11200	Rebastinib		***	FLT3,KDR,Tie-2
A15849	GZD824 Dimesylate	****	****
A11439	GNF-2	*
A15887	GNF-7	***	*
A13029	Radotinib	**
A16320	Dasatinib Monohydrate	****	****	Src,c-Kit (D816V),c-Kit (wt)
A13237	GNF-5	*
A13120	PD173955	***		Src
A11379	DPH
A13530	Flumatinib mesylate		****	PDGFRβ, c-Kit

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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NVP-BHG712

Catalog No. A10661
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EphB4 抑制剂

NVP-BHG712是EphB4激酶的选择性抑制剂，在体外对EphB4的选择性超过40多种其他激酶（包括FGFR3）。了解更多

Product Citations (1)

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- Y Kaibori, .et al. EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity, the FASEB Journal, 2019, Jan 22:fj201801519RR PMID: 30668924