FLT3

Catalog No.Inhibitor Name FLT3Other
A10996Cabozantinib
**
VEGFR2/KDR,c-Met,Kit
A10027Quizartinib
***
A11411Dovitinib
****
c-Kit,VEGFR3/FLT4,FGFR1
A10610Amuvatinib
*
c-Kit (D816H),PDGFRα (V561D)
A10887Tandutinib
*
c-Kit,PDGFRβ,CSF-1R
A11180TG101209
*
JAK2,RET,JAK3
A10508KW-2449
****
Abl (T315I),Abl,FGFR1
A10352ENMD-2076
***
RET,Aurora A,VEGFR3/FLT4
A10198Dovitinib Dilactic Acid
****
c-Kit,FGFR1,VEGFR3/FLT4
A12694Pacritinib
**
JAK2 (V617F),JAK2,TYK2
A12427TCS 359
*
A10352ENMD-2076 L-(*)-Tartaric acid
RET,Aurora A,VEGFR3/FLT4
A15904UNC2025
****
Mer
A14025AMG 925
****
CDK4,CDK1
A14214G-749
****
Mer,Aurora B,RET
A14156AZD2932
PDGFRβ,VEGFR-2,c-Kit
A10769R406
Syk
A12419Go6976
JAK2,PKCα,PKCβ1
A11962TG-02 (SB1317)
*
CDK2, JAK2
A14411Gilteritinib (ASP2215)
****
Axl
A15003AST 487
Ret, c-Kit, KDR, c-Abl
A15520Pexidartinib (PLX3397)
*
Kit, CSF-1R
A15548SU5614
A16248BPR1J-097
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Dovitinib (TKI-258)

    Catalog No. A11411
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    RTK 抑制剂
    Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂,可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞,IC50值分别为150 nM和90 nM。 了解更多
  2. Dovitinib Dilactic acid (TKI258 Dilactic acid)

    Catalog No. A10198
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    RTK 抑制剂
    Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂,可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞,IC50值分别为150 nM和90 nM。 了解更多
  3. Tandutinib (MLN518)

    Catalog No. A10887
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    FLT3 抑制剂
    Tandutinib (MLN518)是一种有效的FLT3抑制剂,c-KIT和PDGF受体酪氨酸激酶的自磷酸化,从而抑制细胞增殖并诱导细胞凋亡。 了解更多
  4. AC710 Mesylate

    Catalog No. A16246
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    FLT3/KIT/PDGFRα/PDGFRβ 抑制剂
    AC710 Mesylate是一种有效的选择性PDGFR家族激酶抑制剂,对于FLT3/KIT/PDGFRα/PDGFRβ的Kd值分别为0.6 nM/1.0 nM/1.3 nM/1.0 nM。 了解更多
  5. Crenolanib (CP-868596)

    Catalog No. A11052
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    PDGFR/FLT3 抑制剂
    Crenolanib (CP-868596)是口服生物可用的PDGFR酪氨酸激酶的选择性小分子抑制剂,在皮摩尔浓度下抑制PDGFRA和PDGFRB。 了解更多

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