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搜索结果：“HSP”

“HSP”的搜索结果

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HSP-990

Catalog No. A12850
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HSP90 抑制剂

HSP990是人热休克蛋白90（Hsp90）的口服生物利用抑制剂，对HSP90α/β的IC50分别为0.6 nM和0.8 nM。具有潜在的抗肿瘤活性。了解更多

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- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
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VER 155008

Catalog No. A13351
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HSP 70 抑制剂

VER 155008是HSP70的小分子ATP衍生物抑制剂（IC50 = 500 nM）。了解更多

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- Hiroshi Katoh, .et al. Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation, J Virol, 2017, Mar 15; 91(6): e02220-16 PMID: 28053100
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MKT 077

Catalog No. A12388
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HSP70 抑制剂

MKT 077的p53结合位点，并使p53易位至细胞核。选择性细胞毒性；导致培养物中癌细胞生长停滞。也抑制端粒酶活性和交联f-肌动蛋白。了解更多

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XL-888

Catalog No. A11251
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HSP90 抑制剂

XL888是口服可生物利用的，具有ATP竞争性的小分子热休克蛋白90（Hsp90）抑制剂，IC50为24 nM。具有潜在的抗肿瘤活性。了解更多

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ACY-1215 (Rocilinostat)

Catalog No. A11940
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HDAC6 抑制剂

ACY-1215 (Rocilinostat)是一种选择性HDAC6抑制剂，从而通过Hsp90的超乙酰化作用破坏Hsp90蛋白伴侣系统，并防止随后的总蛋白降解。了解更多

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SNX-2112

Catalog No. A11189
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Hsp90 抑制剂

SNX-2112是目前在临床试验中具有抗癌特性的热激蛋白90（Hsp90）抑制剂。SNX-2112通过Akt/mTOR/p70S6K抑制以时间和剂量依赖的方式诱导自噬。SNX-2112在人黑素瘤A-375细胞中诱导明显的凋亡和自噬，可能是有效的靶向治疗剂。了解更多

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- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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17-DMAG HCl (Alvespimycin)

Catalog No. A10011
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Hsp90 抑制剂

17-DMAG HCl (Alvespimycin)是17-AAG和格尔德霉素的水溶性类似物，与Hsp90的ATP结合位点结合并抑制其伴侣活性。显示出比17-AAG更有效的抗肿瘤活性。了解更多

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- Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7
- Naoki Shiraishi, .et al. Heat shock protein 90 as a molecular target for therapy in oral squamous cell carcinoma: Inhibitory effects of 17?DMAG and ganetespib on tumor cells, Oncol Rep, 2020, 448-458 PMID: 33416122
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Ganetespib (STA-9090)

Catalog No. A11402
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Hsp90 抑制剂

Ganetespib (STA-9090)是Hsp90的有效合成小分子抑制剂，Hsp90是一种伴侣蛋白，对于某些其他蛋白的功能至关重要，这些蛋白可驱动许多不同类型的癌症的生长，增殖和存活。了解更多

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- Tung-Yun Wu, .et al. Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment, J Adv Res, 2022, Jun 22;S2090-1232(22)00148-5 PMID: 35752438
- Aykut Ozgur, .et al. Investigation of anticancer activities of STA-9090 (ganetespib) as a second generation HSP90 inhibitor in Saos-2 osteosarcoma cells, J Chemother, 2021, Apr 2;1-10 PMID: 33794753
- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
- Kosinsky RL, .et al. USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer, Cell Death Dis, 2019, Dec 4;10(12):911 PMID: 31801945
- Yamada-Kanazawa S, .et al. Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway, Br J Dermatol, 2017, Aug;177(2):456-469 PMID: 28078663
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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Geldanamycin

Catalog No. A11025
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Hsp90 抑制剂

Geldanamycin与Hsp90的ATP位点（Kd = 1.2μM）结合并抑制其分子伴侣活性。了解更多

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- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
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Onalespib (AT13387)

Catalog No. A11062
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HSP90 抑制剂

Onalespib (AT13387)是Hsp90的靶向抑制剂，可抑制其伴侣功能并促进涉及肿瘤细胞增殖和存活的致癌信号蛋白的降解。了解更多

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- Boucherat O, .et al. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension, Am J Respir Crit Care Med, 2018, Jul 1;198(1):90-103 PMID: 29394093
- Olivier Boucherat, .et al. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension, Sci Rep, 2017, 7: 4546 PMID: 28674407
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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BIIB021

Catalog No. A10143
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HSP90 抑制剂

BIIB021是一种口服全合成Hsp90抑制剂，可选择性和有效地抑制分子伴侣Hsp90。了解更多

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- Ting-Yu Chang, .et al. A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling, Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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AUY922 (Luminespib, NVP-AUY922)

Catalog No. A10659
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HSP90 抑制剂

AUY922 (Luminespib,NVP-AUY922)是一种高效的HSP90抑制剂，在Hsp90 FP结合测定中的IC50 = 21 nM，并在体外抑制多种人类癌细胞系的增殖，GI50平均为9 nM。Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂，无细胞试验中作用于HSP90α/β的IC50为13 nM /21 nM，对HSP90家族成员GRP94和TRAP-1具有稍弱的作用，与任何小分子HSP90配体均可紧密结合。了解更多

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- Haruka Wakasa, .et al. Adverse Effects of High Temperature On Mammary Alveolar Development In Vitro, J Mammary Gland Biol Neoplasia, 2022, Jun;27(2):155-170 PMID: 35581442
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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17-AAG (KOS953)

Catalog No. A10010
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HSP90 抑制剂

17-AAG (KOS953)是一种有效的HSP90抑制剂，无细胞试验中IC50为5 nM，作用于来自肿瘤细胞的HSP90比作用于来自正常细胞HSP90结合亲和力高100倍。了解更多

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- Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7