“ab fubinaca”的搜索结果

产品 151 到 200 共 366个

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  1. TVB-3664

    Catalog No. A18829
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    FASN inhibitor
    TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor, with IC50 values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression. 了解更多
  2. HSP27 inhibitor J2

    Catalog No. A18874
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    HSP27 inhibitor
    HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. 了解更多
  3. CHDI-390576

    Catalog No. A18899
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    HDAC inhibitor
    CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. 了解更多
  4. CD-161

    Catalog No. A18921
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    BET inhibitor
    CD-161 is a potent and orally bioavailable BET inhibitor with an IC50s of 28.2 nM and 7.2 nM for BRD4 BD1 and BRD4 BD2, respectively. 了解更多
  5. PTC299

    Catalog No. A18935
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    VEGFA inhibitor
    PTC299 is a potent, orally bioavailable VEGFA inhibitor, targets dihydroorotate dehydrogenase (DHODH), resulting in cell growth inhibition and differentiation in leukemias, including acute myeloid leukemia, linking DHODH regulation and stress-induced VEGFA and angiogenesis. 了解更多
  6. AZD9898

    Catalog No. A18959
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    LTC4S inhibitor
    AZD9898 is an orally active leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma. 了解更多
  7. 2-Hydroxy atorvastatin calcium salt

    Catalog No. A18971
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    HMG-CoA reductase inhibitor
    2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. 了解更多
  8. Parbendazole

    Catalog No. A18981
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    Microtubule assembly inhibitor
    Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79?nM, and exhibits a broad-spectrum anthelmintic activity. 了解更多
  9. KT185

    Catalog No. A19007
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    ABHD6 inhibitor
    KT185 is an orally-bioavailable, brain-penetrant and selective ABHD6 inhibitor, with an IC50 0.21 nM in Neuro2A cells. 了解更多
  10. GNE-616

    Catalog No. A19046
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    Nav1.7 inhibitor
    GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1.7 inhibitor (Ki of 0.79 nM and Kd of 0.38 nM for hNav1.7) for the treatment of chronic pain. 了解更多
  11. Syncytial Virus Inhibitor-1

    Catalog No. A19053
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    RSV fusion inhibitor
    Syncytial Virus Inhibitor-1 is a potent, orally bioavailable respiratory syncytial virus (RSV) fusion inhibitor with EC50s of 0.002 μM, 0.004 μM, and 0.002 μM for RSV Long, RSV A2, and RSV B strains, respectively. 了解更多
  12. Raphin1

    Catalog No. A19060
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    PPP1R15B inhibitor
    Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). 了解更多
  13. BI-4924

    Catalog No. A19064
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    PHGDH inhibitor
    BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. 了解更多
  14. CHMFL-ABL-121

    Catalog No. A19079
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    ABL2 inhibitor
    CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively. 了解更多
  15. Vanin-1-IN-1

    Catalog No. A19095
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    Vanin-1 enzyme inhibitor
    Vanin-1-IN-1 is an inhibitor of vanin-1 enzyme which is a cell surface associated, giycosyiphosphatidyS inositol (GPi) anchored protein and plays an important role in metabolism and inflammation. 了解更多
  16. S18-000003

    Catalog No. A19105
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    RORγt 抑制剂
    S18-000003 is a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor with an IC50 of 29 nM. S18-000003 inhibits IL-17 production. 了解更多
  17. LIN28 inhibitor LI71

    Catalog No. A19107
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    LIN28 inhibitor
    LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. 了解更多
  18. CD235

    Catalog No. A19115
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    BET bromodomain inhibitor
    CD235 is a structurally similar analogue of CD161. CD161 is a potent and orally bioavailable BET bromodomain inhibitor. 了解更多
  19. RP 70676

    Catalog No. A19362
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    ACAT inhibitor
    RP 70676 is a potent inhibitor of ACAT, with IC50 of 25 and 44 nM for rat and rabbit ACAT. 了解更多
  20. MSDC-0602

    Catalog No. A19368
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    MPC inhibitor
    MSDC-0602, a PPARγ-sparing thiazolidinedione (TZD), interacts with the mitochondrial pyruvate carrier (MPC) and inhibits its activity and are effective for treatment of type 2 diabetes with reducing risk of PPARγ-mediated side effects. 了解更多
  21. TM5441

    Catalog No. A19369
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    PAI-1 inhibitor
    TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. 了解更多
  22. Fidarestat (SNK-860)

    Catalog No. A11790
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    Aldose reductase inhibitor
    Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease. 了解更多
  23. AR-9281

    Catalog No. A19412
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    s-EH inhibitor
    AR9281 is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH), with potential for the treatment of hypertension and type 2 diabetes. 了解更多
  24. SCH28080

    Catalog No. A19424
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    H+/K+-ATPase inhibitor
    SCH28080 inhibits gastric H+/K+-ATPase by K+-competitive binding, with an IC50 value of 20 nM in rabbit microsomal membranes. Antisecretory and cytoprotective activities. 了解更多
  25. CZC-8004

    Catalog No. A19444
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    ABL inhibitor
    CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase. 了解更多
  26. LSN 3213128

    Catalog No. A19472
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    AICARFT inhibitor
    LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity. 了解更多
  27. ND-646

    Catalog No. A20079
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    ACC inhibitor
    ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. 了解更多
  28. U18666A

    Catalog No. A20195
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    cholesterol synthesis/Hedgehog inhibitor
    U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. 了解更多
  29. A939572

    Catalog No. A13298
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    SCD1 inhibitor
    A939572 is a potent, and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively. 了解更多
  30. PD146176 (NSC168807)

    Catalog No. A13347
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    15-LO inhibitor
    PD146176 (NSC168807) is a 15-Lipoxygenase (15-LO) inhibitor, which inhibits rabbit reticulocyte 15-LO with a Ki of 197 nM. PD146176 (NSC168807) has a dramatic effect in reducing atherogenesis. 了解更多
  31. Dihydroactinidiolide

    Catalog No. A12142
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    plant growth inhibitor
    Dihydroactinidiolide, existing in plant leaves and fruits, is a potent plant growth inhibitor, a regulator of gene expression and is responsible for photo acclimation in Arabidopsis. 了解更多
  32. MI-1061

    Catalog No. A18450
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    MDM2 inhibitor
    MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity. 了解更多
  33. ALK-IN-6

    Catalog No. A18457
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    ALK inhibitor
    ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively. 了解更多
  34. TAB29

    Catalog No. A18467
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    Pin1 inhibitor
    TAB29 is a potent inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with an IC50 of 874?nM, possesses therapeutic potential for human cancers. 了解更多
  35. AB-680

    Catalog No. A18534
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    CD73 inhibitor
    AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity. 了解更多
  36. VP3.15

    Catalog No. A18538
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    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多
  37. Bozitinib

    Catalog No. A18554
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    c-MET kinase inhibitor
    Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily. 了解更多
  38. ACX-362E

    Catalog No. A18560
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    DNA polymerase IIIC 抑制剂
    ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens. 了解更多
  39. SNIPER(ABL)-062

    Catalog No. A18567
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    ABL inhibitor
    SNIPER(ABL)-062, in which an ABL inhibitor is linked to a ligand of cIAP1 via a linker containing a variable polyethylene glycol (PEG) unit, shows a potent activity to degrade the BCR-ABL protein. 了解更多
  40. D13-9001

    Catalog No. A18570
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    AcrB and MexB inhibitor
    D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively. D13-9001 exhibits antibiotic activities. 了解更多
  41. Col003

    Catalog No. A18573
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    Hsp47 inhibitor
    Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix. 了解更多
  42. PF-06250112

    Catalog No. A18612
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    BTK 抑制剂
    PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. 了解更多
  43. ML367

    Catalog No. A18622
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    ATAD5 inhibitor
    ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. 了解更多
  44. Atreleuton

    Catalog No. A18623
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    5-Lipoxygenase (5-LO) inhibitor
    Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation. 了解更多
  45. ABX-1431

    Catalog No. A18652
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    MAGL inhibitor
    ABX-1431 is a highly potent, selective, and orally available, CNS-penetrant monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 14 nM. 了解更多
  46. GNE-8505

    Catalog No. A18672
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    DLK inhibitor
    GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK). 了解更多
  47. DPM-1001

    Catalog No. A18674
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    PTP1B inhibitor
    DPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=600 nM). DPM-1001 has anti-diabetic property. 了解更多
  48. ZK824859

    Catalog No. A18680
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    uPA inhibitor
    ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively. 了解更多
  49. NGI-1

    Catalog No. A18706
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    OST inhibitor
    NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocking the function of the OST catalytic subunits STT3A and STT3B. NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability. 了解更多
  50. SGL5213

    Catalog No. A18723
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    SGLT1 抑制剂
    SGL5213 is a potent, oral active and low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, with IC50 values of 29 nM and 20 nM for hSGLT1 and hSGLT2, respectively. 了解更多

产品 151 到 200 共 366个

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