γ-Secretase

Catalog No.Inhibitor Name γ secretaseNotchOther
A10288DAPT (GSI-IX)
*
A10802RO4929097
***
***
Aβ40
A10836Semagacestat
**
**
A10157Avagacestat
****
A11174Dibenzazepine
***
***
A11176LY411575
****
****
A15899L-685458
*
A13815FLI-06
*
A13319PF-03084014
**
A11194MK-0752
***
Aβ40
A13544LY3039478
****
A16152IMR-1
*
A16223IMR-1A
*
A11258Begacestat (GSI-953)
**
A12444BMS 299897
A13217TC-E 5006
*
A15304MRK 560
****
A15301JLK 6
A16214CHF5074
*
A16215Z-Ile-Leu-aldehyde

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. NGP-555

    Catalog No. A17051
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    γ-Secretase Modulator
    NGP-555是一种γ-分泌酶调节剂,具有选择性机制,可减少Abeta 42,同时提高较短的Abeta形式,例如Abeta 37和38。 了解更多
  2. BPN-15606

    Catalog No. A18681
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    γ-secretase modulator
    BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. 了解更多
  3. Flurizan

    Catalog No. A12433
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    gamma-secretase modulator
    Flurizan是一种非甾体抗炎药(NSAID),可抑制γ-分泌酶的活性。 了解更多
  4. E 2012

    Catalog No. A11393
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    gamma-secretase modulator
    E 2012是γ-secretase抑制剂。 了解更多
  5. CHF5074

    Catalog No. A16214
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    γ-Secretase modulator
    CHF5074是新型的γ-分泌酶调节剂,可减少Aβ42和Aβ40的分泌,IC50分别为3.6和18.4 uM。 了解更多
  6. TC-E 5006

    Catalog No. A13217
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    Gamma-secretase modulator
    TC-E 5006是一种γ-分泌酶调节剂。在体外(EC50 = 390 nM)和体内降低Aβ42水平。 了解更多
  7. gamma-secretase modulator 2

    Catalog No. A11427
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    Gamma-secretase modulator
    Gamma-secretase modulator 2是γ-secretase调节剂,可用于阿尔兹海默。 了解更多
  8. gamma-secretase modulator 1

    Catalog No. A11425
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    Gamma-secretase modulator
    gamma-secretase modulator 1是γ-分泌酶调节剂,γ-分泌酶调节剂1可用于阿尔茨海默病。 了解更多
  9. Compound W

    Catalog No. A15296
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    Gamma-secretase modulator
    Compound W是一种γ-分泌酶抑制剂,已被证明可以降低分泌的Aβ42和Nβ25的水平。 了解更多
  10. gamma-secretase modulator 3

    Catalog No. A15090
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    gamma-secretase modulator
    gamma-secretase modulator 3 是γ-分泌酶调节剂。 了解更多

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